TYSND1

Protein-coding gene in the species Homo sapiens
TYSND1
Identifiers
AliasesTYSND1, NET41, trypsin domain containing 1, trypsin like peroxisomal matrix peptidase 1
External IDsOMIM: 611017; MGI: 1919017; HomoloGene: 87946; GeneCards: TYSND1; OMA:TYSND1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for TYSND1
Genomic location for TYSND1
Band10q22.1Start70,137,981 bp[1]
End70,146,700 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for TYSND1
Genomic location for TYSND1
Band10|10 B4Start61,531,293 bp[2]
End61,538,552 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • skin of abdomen

  • skin of leg

  • mucosa of transverse colon

  • granulocyte

  • right adrenal gland

  • right lobe of liver

  • right lobe of thyroid gland

  • left adrenal gland
Top expressed in
  • right kidney

  • proximal tubule

  • left lobe of liver

  • brown adipose tissue

  • internal carotid artery

  • human kidney

  • adrenal gland

  • external carotid artery

  • ankle joint

  • duodenum
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protease binding
  • peptidase activity
  • serine-type peptidase activity
  • hydrolase activity
  • identical protein binding
  • serine-type endopeptidase activity
Cellular component
  • peroxisome
  • membrane
  • peroxisomal matrix
  • cytosol
Biological process
  • protein processing
  • regulation of fatty acid beta-oxidation
  • protein homooligomerization
  • proteolysis
  • protein targeting to peroxisome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

219743

71767

Ensembl

ENSG00000156521

ENSMUSG00000020087

UniProt

Q2T9J0

Q9DBA6

RefSeq (mRNA)

NM_001040273
NM_173555

NM_001272090
NM_001272091
NM_001272092
NM_027912

RefSeq (protein)

NP_001035363
NP_775826

NP_001259019
NP_001259020
NP_001259021
NP_082188

Location (UCSC)Chr 10: 70.14 – 70.15 MbChr 10: 61.53 – 61.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Trypsin domain containing 1 is a protein that in humans is encoded by the TYSND1 gene. [5]

Function

This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome.

The encoded protein is also capable of cleaving several proteins targeted to peroxisomes through the C-terminal peroxisomal targeting signal (PTS1). The full-length protein undergoes self-cleavage to produce shorter, potentially inactive fragments. Alternative splicing results in multiple transcript variants for this gene.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156521 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020087 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Trypsin domain containing 1". Retrieved 2017-10-02.

Further reading

  • Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
  • Kurochkin IV, Mizuno Y, Konagaya A, Sakaki Y, Schönbach C, Okazaki Y (2007). "Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids". EMBO J. 26 (3): 835–45. doi:10.1038/sj.emboj.7601525. PMC 1794383. PMID 17255948.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e