Transcription initiation protein SPT3 homolog

Protein-coding gene in the species Homo sapiens
SUPT3H
Identifiers
AliasesSUPT3H, SPT3, SPT3L, SPT3 homolog, SAGA and STAGA complex component
External IDsOMIM: 602947; MGI: 1923723; HomoloGene: 121570; GeneCards: SUPT3H; OMA:SUPT3H - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SUPT3H
Genomic location for SUPT3H
Band6p21.1Start44,809,317 bp[1]
End45,377,953 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for SUPT3H
Genomic location for SUPT3H
Band17|17 B3Start45,088,039 bp[2]
End45,430,177 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • sperm

  • testicle

  • oocyte

  • left testis

  • sural nerve

  • right testis

  • cartilage tissue

  • ventricular zone

  • left ovary
Top expressed in
  • hand

  • interventricular septum

  • muscle of thigh

  • primary oocyte

  • zygote

  • seminiferous tubule

  • spermatid

  • otolith organ

  • granulocyte

  • utricle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein heterodimerization activity
  • histone acetyltransferase activity
  • transcription coactivator activity
  • DNA binding
  • transcription coregulator activity
Cellular component
  • transcription factor TFTC complex
  • nucleus
  • nucleoplasm
  • SAGA complex
  • transcription factor TFIID complex
Biological process
  • regulation of transcription by RNA polymerase II
  • positive regulation of transcription, DNA-templated
  • histone deubiquitination
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • histone H3 acetylation
  • transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8464

109115

Ensembl

ENSG00000196284

ENSMUSG00000038954

UniProt

O75486

n/a

RefSeq (mRNA)
NM_001261823
NM_003599
NM_181356
NM_001350324
NM_001350325

NM_001350326
NM_001350327
NM_001350329

NM_178652
NM_001357320

RefSeq (protein)
NP_001248752
NP_003590
NP_852001
NP_001337253
NP_001337254

NP_001337255
NP_001337256
NP_001337258

n/a

Location (UCSC)Chr 6: 44.81 – 45.38 MbChr 17: 45.09 – 45.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.[5][6][7]

Interactions

Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,[8][9] TAF6L,[9] TADA3L,[9] TAF5L,[9] SF3B3,[9] SUPT7L,[9] Myc,[10] TAF9,[9] Transformation/transcription domain-associated protein,[9] TAF12,[9] TAF10,[8][9] TAF4[8] and DDB1.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196284 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038954 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425. S2CID 18942972.
  6. ^ Martinez E, Kundu TK, Fu J, Roeder RG (Sep 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". The Journal of Biological Chemistry. 273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID 9726987.
  7. ^ "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)".
  8. ^ a b c Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
  9. ^ a b c d e f g h i j k Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
  10. ^ Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.

Further reading

  • Yu J, Madison JM, Mundlos S, Winston F, Olsen BR (Oct 1998). "Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor spt3 (SUPT3H)". Genomics. 53 (1): 90–6. doi:10.1006/geno.1998.5500. PMID 9787080.
  • Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y (Dec 1998). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Molecular Cell. 2 (6): 869–75. doi:10.1016/S1097-2765(00)80301-9. PMID 9885574.
  • Brand M, Yamamoto K, Staub A, Tora L (Jun 1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". The Journal of Biological Chemistry. 274 (26): 18285–9. doi:10.1074/jbc.274.26.18285. PMID 10373431.
  • Speek M (Mar 2001). "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes". Molecular and Cellular Biology. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC 86790. PMID 11238933.
  • Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
  • Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
  • Cavusoglu N, Brand M, Tora L, Van Dorsselaer A (Feb 2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics. 3 (2): 217–23. doi:10.1002/pmic.200390030. PMID 12601814. S2CID 6035986.
  • Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.