Protein-coding gene in the species Homo sapiens
SUPT3H |
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Identifiers |
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Aliases | SUPT3H, SPT3, SPT3L, SPT3 homolog, SAGA and STAGA complex component |
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External IDs | OMIM: 602947; MGI: 1923723; HomoloGene: 121570; GeneCards: SUPT3H; OMA:SUPT3H - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 6 (human)[1] |
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| Band | 6p21.1 | Start | 44,809,317 bp[1] |
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End | 45,377,953 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 17 (mouse)[2] |
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| Band | 17|17 B3 | Start | 45,088,039 bp[2] |
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End | 45,430,177 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gonad
- sperm
- testicle
- oocyte
- left testis
- sural nerve
- right testis
- cartilage tissue
- ventricular zone
- left ovary
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| Top expressed in | - hand
- interventricular septum
- muscle of thigh
- primary oocyte
- zygote
- seminiferous tubule
- spermatid
- otolith organ
- granulocyte
- utricle
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - protein heterodimerization activity
- histone acetyltransferase activity
- transcription coactivator activity
- DNA binding
- transcription coregulator activity
| Cellular component | - transcription factor TFTC complex
- nucleus
- nucleoplasm
- SAGA complex
- transcription factor TFIID complex
| Biological process | - regulation of transcription by RNA polymerase II
- positive regulation of transcription, DNA-templated
- histone deubiquitination
- regulation of transcription, DNA-templated
- transcription by RNA polymerase II
- histone H3 acetylation
- transcription, DNA-templated
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001261823 NM_003599 NM_181356 NM_001350324 NM_001350325
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NM_001350326 NM_001350327 NM_001350329 |
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RefSeq (protein) | NP_001248752 NP_003590 NP_852001 NP_001337253 NP_001337254
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NP_001337255 NP_001337256 NP_001337258 |
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Location (UCSC) | Chr 6: 44.81 – 45.38 Mb | Chr 17: 45.09 – 45.43 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.[5][6][7]
Interactions
Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,[8][9] TAF6L,[9] TADA3L,[9] TAF5L,[9] SF3B3,[9] SUPT7L,[9] Myc,[10] TAF9,[9] Transformation/transcription domain-associated protein,[9] TAF12,[9] TAF10,[8][9] TAF4[8] and DDB1.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000196284 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038954 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425. S2CID 18942972.
- ^ Martinez E, Kundu TK, Fu J, Roeder RG (Sep 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". The Journal of Biological Chemistry. 273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID 9726987.
- ^ "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)".
- ^ a b c Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
- ^ a b c d e f g h i j k Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
- ^ Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.
Further reading
- Yu J, Madison JM, Mundlos S, Winston F, Olsen BR (Oct 1998). "Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor spt3 (SUPT3H)". Genomics. 53 (1): 90–6. doi:10.1006/geno.1998.5500. PMID 9787080.
- Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y (Dec 1998). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Molecular Cell. 2 (6): 869–75. doi:10.1016/S1097-2765(00)80301-9. PMID 9885574.
- Brand M, Yamamoto K, Staub A, Tora L (Jun 1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". The Journal of Biological Chemistry. 274 (26): 18285–9. doi:10.1074/jbc.274.26.18285. PMID 10373431.
- Speek M (Mar 2001). "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes". Molecular and Cellular Biology. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC 86790. PMID 11238933.
- Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
- Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
- Cavusoglu N, Brand M, Tora L, Van Dorsselaer A (Feb 2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics. 3 (2): 217–23. doi:10.1002/pmic.200390030. PMID 12601814. S2CID 6035986.
- Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.