Transgelin

Protein-coding gene in the species Homo sapiens

TAGLN

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1UJO

Identifiers

Aliases

TAGLN, SM22, SMCC, TAGLN1, WS3-10, transgelin, SM22-alpha

External IDs

OMIM: 600818; MGI: 106012; HomoloGene: 2398; GeneCards: TAGLN; OMA:TAGLN - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q23.3	Start	117,199,370 bp^[1]
Band	11q23.3	End	117,207,464 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 A5.2\|9 25.36 cM	Start	45,840,917 bp^[2]
Band	9 A5.2\|9 25.36 cM	End	45,847,356 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

saphenous vein

popliteal artery

tibial arteries

right coronary artery

ascending aorta

Descending thoracic aorta

left coronary artery

tail of epididymis

myometrium

urethra

Top expressed in

tunica media of zone of aorta

ascending aorta

belly cord

cervix

aortic valve

seminal vesicula

left colon

calvaria

gallbladder

tunica adventitia of aorta

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding actin binding actin filament binding
Cellular component	cytoplasm
Biological process	muscle organ development epithelial cell differentiation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6876


21345

Ensembl


ENSG00000149591


ENSMUSG00000032085

UniProt


Q01995


P37804

RefSeq (mRNA)


NM_003186 NM_001001522


NM_011526

RefSeq (protein)


NP_001001522 NP_003177


NP_035656

Location (UCSC)

Chr 11: 117.2 – 117.21 Mb

Chr 9: 45.84 – 45.85 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Transgelin is a protein that in humans is encoded by the TAGLN gene.^[5]^[6]^[7]

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149591 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032085 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kobayashi R, Kubota T, Hidaka H (Mar 1994). "Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog". Biochem Biophys Res Commun. 198 (3): 1275–80. doi:10.1006/bbrc.1994.1180. PMID 8117285.
^ Thweatt R, Lumpkin CK Jr, Goldstein S (Oct 1992). "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts". Biochem Biophys Res Commun. 187 (1): 1–7. doi:10.1016/S0006-291X(05)81449-4. PMID 1520290.
^ ^a ^b "Entrez Gene: TAGLN transgelin".

Nishida W, Kitami Y, Abe M, Hiwada K (1991). "Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle". Biochem. Int. 23 (4): 663–8. PMID 1872880.
Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1" (PDF). DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Li L, Liu Z, Mercer B, et al. (1997). "Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells". Dev. Biol. 187 (2): 311–21. doi:10.1006/dbio.1997.8621. PMID 9242426.
Yamamura H, Masuda H, Ikeda W, et al. (1997). "Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation". J. Biochem. 122 (1): 157–67. doi:10.1093/oxfordjournals.jbchem.a021722. PMID 9276683.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lawson D, Harrison M, Shapland C (1998). "Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines". Cell Motil. Cytoskeleton. 38 (3): 250–7. doi:10.1002/(SICI)1097-0169(1997)38:3<250::AID-CM3>3.0.CO;2-9. PMID 9384215.
Camoretti-Mercado B, Forsythe SM, LeBeau MM, et al. (1998). "Expression and cytogenetic localization of the human SM22 gene (TAGLN)". Genomics. 49 (3): 452–7. doi:10.1006/geno.1998.5267. PMID 9615232.
Fu Y, Liu HW, Forsythe SM, et al. (2001). "Mutagenesis analysis of human SM22: characterization of actin binding". J. Appl. Physiol. 89 (5): 1985–90. doi:10.1152/jappl.2000.89.5.1985. PMID 11053353. S2CID 1573662.
Shields JM, Rogers-Graham K, Der CJ (2002). "Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways". J. Biol. Chem. 277 (12): 9790–9. doi:10.1074/jbc.M110086200. PMID 11773051.
Chainiaux F, Magalhaes JP, Eliaers F, et al. (2002). "UVB-induced premature senescence of human diploid skin fibroblasts". Int. J. Biochem. Cell Biol. 34 (11): 1331–9. doi:10.1016/S1357-2725(02)00022-5. PMID 12200029.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Xu R, Ho YS, Ritchie RP, Li L (2003). "Human SM22 alpha BAC encompasses regulatory sequences for expression in vascular and visceral smooth muscles at fetal and adult stages". Am. J. Physiol. Heart Circ. Physiol. 284 (4): H1398–407. doi:10.1152/ajpheart.00737.2002. PMID 12521938.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Yang Z, Chang YJ, Miyamoto H, et al. (2007). "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. doi:10.1210/me.2006-0104. PMID 17082327.
Liao X, Li S, Lou Z, et al. (2007). "Crystallization and preliminary crystallographic analysis of transgelin". Protein Pept. Lett. 14 (2): 209–11. doi:10.2174/092986607779816122. PMID 17305610.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.