Tropomodulin 1

Protein-coding gene in the species Homo sapiens
TMOD1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4PKG, 4PKH, 4PKI, 4Z8G, 4Z94

Identifiers
AliasesTMOD1, D9S57E, ETMOD, TMOD, tropomodulin 1
External IDsOMIM: 190930; MGI: 98775; HomoloGene: 20701; GeneCards: TMOD1; OMA:TMOD1 - orthologs
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[1]
Chromosome 4 (mouse)
Genomic location for TMOD1
Genomic location for TMOD1
Band4 B1|4 24.49 cMStart46,038,935 bp[1]
End46,116,032 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • gastric mucosa

  • spinal ganglia

  • left ventricle

  • skeletal muscle tissue

  • body of tongue

  • quadriceps femoris muscle

  • vastus lateralis muscle

  • deltoid muscle

  • trigeminal ganglion
Top expressed in
  • quadriceps femoris muscle

  • right ventricle

  • muscle of thigh

  • myocardium of ventricle

  • gastrocnemius muscle

  • temporal muscle

  • utricle

  • skeletal muscle tissue

  • medial head of gastrocnemius muscle

  • sternocleidomastoid muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • actin filament binding
  • actin binding
  • tropomyosin binding
Cellular component
  • membrane
  • COP9 signalosome
  • cytoskeleton
  • cytosol
  • cortical cytoskeleton
  • cytoplasm
  • sarcomere
  • myofibril
  • actin filament
  • striated muscle thin filament
Biological process
  • adult locomotory behavior
  • lens fiber cell development
  • muscle filament sliding
  • pointed-end actin filament capping
  • muscle contraction
  • actin filament organization
  • myofibril assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7111

21916

Ensembl

n/a

ENSMUSG00000028328

UniProt

P28289

P49813

RefSeq (mRNA)

NM_003275
NM_001166116

NM_021883

RefSeq (protein)

NP_001159588
NP_003266

NP_068683

Location (UCSC)n/aChr 4: 46.04 – 46.12 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.[4][5][6]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028328 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Sung LA, Fowler VM, Lambert K, Sussman MA, Karr D, Chien S (Mar 1992). "Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein". J Biol Chem. 267 (4): 2616–21. doi:10.1016/S0021-9258(18)45926-1. PMID 1370827.
  5. ^ Sung LA, Fan Y, Lin CC (Dec 1996). "Gene assignment, expression, and homology of human tropomodulin". Genomics. 34 (1): 92–6. doi:10.1006/geno.1996.0245. PMID 8661028.
  6. ^ "Entrez Gene: TMOD1 tropomodulin 1".

Further reading

  • Ursitti JA, Fowler VM (1994). "Immunolocalization of tropomodulin, tropomyosin and actin in spread human erythrocyte skeletons". J. Cell Sci. 107 (6): 1633–9. doi:10.1242/jcs.107.6.1633. PMID 7962203.
  • Sung LA, Lin JJ (1994). "Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene". Biochem. Biophys. Res. Commun. 201 (2): 627–34. doi:10.1006/bbrc.1994.1747. PMID 8002995.
  • Sussman MA, Bilak M, Kedes L, et al. (1994). "Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions". Exp. Cell Res. 209 (2): 388–91. doi:10.1006/excr.1993.1325. PMID 8262158.
  • Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics. 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
  • Vera C, Sood A, Gao KM, et al. (2000). "Tropomodulin-binding site mapped to residues 7-14 at the N-terminal heptad repeats of tropomyosin isoform 5". Arch. Biochem. Biophys. 378 (1): 16–24. doi:10.1006/abbi.2000.1802. PMID 10871039.
  • McElhinny AS, Kolmerer B, Fowler VM, et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments". J. Biol. Chem. 276 (1): 583–92. doi:10.1074/jbc.M005693200. PMID 11016930.
  • Chu X, Thompson D, Yee LJ, Sung LA (2001). "Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments". Gene. 256 (1–2): 271–81. doi:10.1016/S0378-1119(00)00327-9. PMID 11054557.
  • Greenfield NJ, Fowler VM (2002). "Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin". Biophys. J. 82 (5): 2580–91. Bibcode:2002BpJ....82.2580G. doi:10.1016/S0006-3495(02)75600-2. PMC 1302047. PMID 11964245.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Rho SB, Chun T, Lee SH, et al. (2004). "The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture". FEBS Lett. 557 (1–3): 57–63. doi:10.1016/S0014-5793(03)01438-8. PMID 14741341. S2CID 84342157.
  • Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. Cancer. 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301. S2CID 875146.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Vera C, Lao J, Hamelberg D, Sung LA (2006). "Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction". Arch. Biochem. Biophys. 444 (2): 130–8. doi:10.1016/j.abb.2005.10.002. PMID 16297372.
  • Kong KY, Kedes L (2006). "Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres". J. Biol. Chem. 281 (14): 9589–99. doi:10.1074/jbc.M512064200. PMID 16434395.
  • v
  • t
  • e
Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects
Stub icon

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e