UBP1

Protein-coding gene in the species Homo sapiens
UBP1
Identifiers
AliasesUBP1, LBP-1B, LBP-1a, LBP1A, LBP1B, upstream binding protein 1 (LBP-1a), upstream binding protein 1
External IDsOMIM: 609784; MGI: 104889; HomoloGene: 8435; GeneCards: UBP1; OMA:UBP1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for UBP1
Genomic location for UBP1
Band3p22.3Start33,388,336 bp[1]
End33,441,371 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for UBP1
Genomic location for UBP1
Band9|9 F3Start113,760,002 bp[2]
End113,806,270 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • rectum

  • sural nerve

  • visceral pleura

  • popliteal artery

  • tibial arteries

  • appendix

  • right coronary artery

  • smooth muscle tissue

  • endothelial cell
Top expressed in
  • Paneth cell

  • medullary collecting duct

  • secondary oocyte

  • tibiofemoral joint

  • primary oocyte

  • zygote

  • ureter

  • renal corpuscle

  • saccule

  • otic vesicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • transcription corepressor activity
  • sequence-specific DNA binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • nucleoplasm
  • cytosol
Biological process
  • viral genome replication
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • angiogenesis
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7342

22221

Ensembl

ENSG00000153560

ENSMUSG00000009741

UniProt

Q9NZI7

Q811S7

RefSeq (mRNA)

NM_001128160
NM_001128161
NM_014517

NM_001083319
NM_013699
NM_001372507
NM_001372508
NM_001372510

NM_001372511
NM_001372512
NM_001372514

RefSeq (protein)

NP_001121632
NP_001121633
NP_055332

NP_001076788
NP_038727
NP_001359436
NP_001359437
NP_001359439

NP_001359440
NP_001359441
NP_001359443

Location (UCSC)Chr 3: 33.39 – 33.44 MbChr 9: 113.76 – 113.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Upstream-binding protein 1 is a protein that in humans is encoded by the UBP1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153560 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009741 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yoon JB, Li G, Roeder RG (Mar 1994). "Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro". Mol Cell Biol. 14 (3): 1776–85. doi:10.1128/mcb.14.3.1776. PMC 358535. PMID 8114710.
  6. ^ "Entrez Gene: UBP1 upstream binding protein 1 (LBP-1a)".

Further reading

  • Kato H, Horikoshi M, Roeder RG (1991). "Repression of HIV-1 transcription by a cellular protein". Science. 251 (5000): 1476–9. Bibcode:1991Sci...251.1476K. doi:10.1126/science.2006421. PMID 2006421.
  • Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro". J. Biol. Chem. 270 (5): 2274–83. doi:10.1074/jbc.270.5.2274. PMID 7836461.
  • Huang N, Miller WL (2000). "Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc". J. Biol. Chem. 275 (4): 2852–8. doi:10.1074/jbc.275.4.2852. PMID 10644752.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zhao H, Li J, Jiang L (2004). "Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)". Biochem. Biophys. Res. Commun. 320 (1): 95–9. doi:10.1016/j.bbrc.2004.05.148. PMID 15207707.
  • Huang N, Miller WL (2005). "LBP proteins modulate SF1-independent expression of P450scc in human placental JEG-3 cells". Mol. Endocrinol. 19 (2): 409–20. doi:10.1210/me.2004-0086. PMID 15471945.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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