UNC93A

Protein-coding gene in the species Homo sapiens
UNC93A
Identifiers
AliasesUNC93A, Unc-93A, dJ366N23.1, dJ366N23.2, UNC93A (gene), unc-93 homolog A (C. elegans), unc-93 homolog A
External IDsOMIM: 607995; MGI: 1933250; HomoloGene: 10356; GeneCards: UNC93A; OMA:UNC93A - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for UNC93A
Genomic location for UNC93A
Band6q27Start167,271,169 bp[1]
End167,316,014 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for UNC93A
Genomic location for UNC93A
Band17 A1|17 8.78 cMStart13,327,504 bp[2]
End13,350,697 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of leg

  • secondary oocyte

  • skin of abdomen

  • right lobe of liver

  • buccal mucosa cell

  • duodenum

  • rectum

  • gallbladder

  • human kidney

  • metanephros
Top expressed in
  • jejunum

  • spermatid

  • esophagus

  • duodenum

  • placenta

  • white adipose tissue

  • colon

  • ileum

  • blastocyst

  • testicle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • molecular function
Cellular component
  • membrane
  • integral component of membrane
  • plasma membrane
Biological process
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54346

381058

Ensembl

ENSG00000112494

ENSMUSG00000067049

UniProt

Q86WB7

Q710D3

RefSeq (mRNA)

NM_001143947
NM_018974

NM_199252

RefSeq (protein)

NP_001137419
NP_061847

NP_954860

Location (UCSC)Chr 6: 167.27 – 167.32 MbChr 17: 13.33 – 13.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.[5]

Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.[6][7] It belongs to the atypical SLCs that was recently listed.[6] It is therefore presumed that UNC93A is a transporter protein.

UNC93A is closely related to UNC93B1 and MFSD11.[8][9]

UNC93A is affected by amino acid deprivation in cell cortex cultures[7][8] and starvation in in vivo samples.[8]

It is expressed in neurons, with staining close to the plasma membrane.[8]

Read also [10][11] for functional studies in C.elegans.


For you who are interested to read more about Unc93A in different species, see: [12]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112494 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067049 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Unc-93 homolog A (C. elegans)".
  6. ^ a b Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  7. ^ a b Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
  8. ^ a b c d Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
  9. ^ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
  10. ^ Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
  11. ^ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMC 6740817. PMID 14534247.
  12. ^ Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology. 8: 580291. doi:10.3389/fcell.2020.580291. ISSN 2296-634X. PMC 7591606. PMID 33163493.

Further reading

  • Liu Y, Dodds P, Emilion G, Mungall AJ, Dunham I, Beck S, Wells RS, Charnock FM, Ganesan TS (October 2002). "The human homologue of unc-93 maps to chromosome 6q27 - characterisation and analysis in sporadic epithelial ovarian cancer". BMC Genetics. 3: 20. doi:10.1186/1471-2156-3-20. PMC 134458. PMID 12381271.


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