Protein-coding gene in the species Homo sapiens
WDR3 |
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Identifiers |
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Aliases | WDR3, DIP2, UTP12, WD repeat domain 3 |
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External IDs | OMIM: 604737; MGI: 2443143; HomoloGene: 4937; GeneCards: WDR3; OMA:WDR3 - orthologs |
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Gene location (Human) |
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![Chromosome 1 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png) | Chr. | Chromosome 1 (human)[1] |
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| Band | 1p12 | Start | 117,929,720 bp[1] |
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End | 117,966,543 bp[1] |
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Gene location (Mouse) |
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![Chromosome 3 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/260px-Ideogram_house_mouse_chromosome_3.svg.png) | Chr. | Chromosome 3 (mouse)[2] |
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| Band | 3|3 F2.2 | Start | 100,045,496 bp[2] |
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End | 100,069,723 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gingival epithelium
- pancreatic ductal cell
- buccal mucosa cell
- parietal pleura
- germinal epithelium
- islet of Langerhans
- visceral pleura
- Epithelium of choroid plexus
- epithelium of nasopharynx
- hair follicle
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| Top expressed in | - primitive streak
- medullary collecting duct
- hand
- condyle
- epiblast
- fossa
- superior cervical ganglion
- abdominal wall
- renal corpuscle
- hair follicle
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/5/55/PBB_GE_WDR3_218882_s_at_fs.png/250px-PBB_GE_WDR3_218882_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - snoRNA binding
- RNA binding
| Cellular component | - Pwp2p-containing subcomplex of 90S preribosome
- small-subunit processome
- nuclear membrane
- nucleolus
- nucleoplasm
- nucleus
| Biological process | - rRNA processing
- maturation of SSU-rRNA
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 117.93 – 117.97 Mb | Chr 3: 100.05 – 100.07 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene.[5][6]
This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000065183 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033285 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Claudio JO, Liew CC, Ma J, Heng HH, Stewart AK, Hawley RG (Aug 1999). "Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13". Genomics. 59 (1): 85–9. doi:10.1006/geno.1999.5858. PMID 10395803.
- ^ a b "Entrez Gene: WDR3 WD repeat domain 3".
Further reading
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- Claudio JO, Liew CC, Dempsey AA, et al. (1999). "Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy". Genomics. 50 (1): 44–52. doi:10.1006/geno.1998.5308. PMID 9628821.