WDR6

Protein-coding gene in the species Homo sapiens
WDR6
Identifiers
AliasesWDR6, WD repeat domain 6, Trm734
External IDsOMIM: 606031; MGI: 1930140; HomoloGene: 117682; GeneCards: WDR6; OMA:WDR6 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for WDR6
Genomic location for WDR6
Band3p21.31Start49,007,062 bp[1]
End49,015,953 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for WDR6
Genomic location for WDR6
Band9|9 F2Start108,449,510 bp[2]
End108,455,938 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • pituitary gland

  • anterior pituitary

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • left ovary

  • right ovary

  • tendon of biceps brachii

  • canal of the cervix

  • body of uterus
Top expressed in
  • arcuate nucleus

  • ventromedial nucleus

  • median eminence

  • paraventricular nucleus of hypothalamus

  • dorsomedial hypothalamic nucleus

  • mammillary body

  • lateral hypothalamus

  • anterior amygdaloid area

  • lateral septal nucleus

  • ventral tegmental area
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • RNA binding
Cellular component
  • cytoplasm
  • COP9 signalosome
  • cytosol
  • plasma membrane
Biological process
  • cell cycle
  • negative regulation of autophagy
  • negative regulation of cell population proliferation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11180

83669

Ensembl

ENSG00000178252

ENSMUSG00000066357

UniProt

Q9NNW5

Q99ME2

RefSeq (mRNA)

NM_018031
NM_001320546
NM_001320547

NM_031392

RefSeq (protein)

NP_001307475
NP_001307476
NP_060501

NP_113569

Location (UCSC)Chr 3: 49.01 – 49.02 MbChr 9: 108.45 – 108.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat-containing protein 6 is a protein that in humans is encoded by the WDR6 gene.[5]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is ubiquitously expressed in adult and fetal tissues.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178252 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066357 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: WDR6 WD repeat domain 6".

Further reading

  • Li D, Roberts R (2002). "WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases". Cell. Mol. Life Sci. 58 (14): 2085–97. doi:10.1007/PL00000838. PMC 11337334. PMID 11814058. S2CID 20646422.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Li D, Burch P, Gonzalez O, et al. (2000). "Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene". Biochem. Biophys. Res. Commun. 274 (1): 117–23. doi:10.1006/bbrc.2000.3012. PMID 10903905.
  • Sano H, Liu SC, Lane WS, et al. (2002). "Insulin receptor substrate 4 associates with the protein IRAS". J. Biol. Chem. 277 (22): 19439–47. doi:10.1074/jbc.M111838200. PMID 11912194.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Xie X, Wang Z, Chen Y (2007). "Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction". Mol. Cell. Biochem. 301 (1–2): 115–22. doi:10.1007/s11010-006-9402-5. PMID 17216128. S2CID 25503392.


  • v
  • t
  • e