WDR8

Protein-coding gene in the species Homo sapiens
WRAP73
Identifiers
AliasesWRAP73, WDR8, WD repeat containing, antisense to TP73
External IDsOMIM: 606040; MGI: 1891749; HomoloGene: 9857; GeneCards: WRAP73; OMA:WRAP73 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for WRAP73
Genomic location for WRAP73
Band1p36.32Start3,630,767 bp[1]
End3,652,761 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for WRAP73
Genomic location for WRAP73
Band4|4 E2Start154,226,829 bp[2]
End154,251,877 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • gonad

  • right hemisphere of cerebellum

  • mucosa of transverse colon

  • spleen

  • anterior pituitary

  • apex of heart

  • blood

  • monocyte

  • body of stomach
Top expressed in
  • condyle

  • fossa

  • medial ganglionic eminence

  • Rostral migratory stream

  • motor neuron

  • saccule

  • facial motor nucleus

  • internal carotid artery

  • external carotid artery

  • medullary collecting duct
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • centrosome
  • centriole
  • cytoskeleton
  • ciliary basal body
  • microtubule organizing center
Biological process
  • positive regulation of non-motile cilium assembly
  • cell projection organization
  • mitotic spindle assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

49856

59002

Ensembl

ENSG00000116213

ENSMUSG00000029029

UniProt

Q9P2S5

Q9JM98

RefSeq (mRNA)

NM_017818

NM_021499

RefSeq (protein)

NP_060288

NP_067474

Location (UCSC)Chr 1: 3.63 – 3.65 MbChr 4: 154.23 – 154.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene.[5]

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification (osteogenesis).[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116213 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029029 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: WDR8 WD repeat domain 8".

Further reading

  • Koshizuka Y, Ikegawa S, Sano M, Nakamura K, Nakamura Y (March 2001). "Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family". Genomics. 72 (3): 252–9. doi:10.1006/geno.2000.6475. PMID 11401440.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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