Protein-coding gene in the species Homo sapiens
WRAP73 |
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Identifiers |
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Aliases | WRAP73, WDR8, WD repeat containing, antisense to TP73 |
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External IDs | OMIM: 606040; MGI: 1891749; HomoloGene: 9857; GeneCards: WRAP73; OMA:WRAP73 - orthologs |
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Gene location (Human) |
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![Chromosome 1 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png) | Chr. | Chromosome 1 (human)[1] |
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| Band | 1p36.32 | Start | 3,630,767 bp[1] |
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End | 3,652,761 bp[1] |
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Gene location (Mouse) |
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![Chromosome 4 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/260px-Ideogram_house_mouse_chromosome_4.svg.png) | Chr. | Chromosome 4 (mouse)[2] |
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| Band | 4|4 E2 | Start | 154,226,829 bp[2] |
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End | 154,251,877 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - granulocyte
- gonad
- right hemisphere of cerebellum
- mucosa of transverse colon
- spleen
- anterior pituitary
- apex of heart
- blood
- monocyte
- body of stomach
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| Top expressed in | - condyle
- fossa
- medial ganglionic eminence
- Rostral migratory stream
- motor neuron
- saccule
- facial motor nucleus
- internal carotid artery
- external carotid artery
- medullary collecting duct
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/5/50/PBB_GE_WDR8_219322_s_at_fs.png/250px-PBB_GE_WDR8_219322_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | | Cellular component | - cytoplasm
- centrosome
- centriole
- cytoskeleton
- ciliary basal body
- microtubule organizing center
| Biological process | - positive regulation of non-motile cilium assembly
- cell projection organization
- mitotic spindle assembly
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 3.63 – 3.65 Mb | Chr 4: 154.23 – 154.25 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene.[5]
Function
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification (osteogenesis).[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000116213 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029029 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: WDR8 WD repeat domain 8".
Further reading
- Koshizuka Y, Ikegawa S, Sano M, Nakamura K, Nakamura Y (March 2001). "Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family". Genomics. 72 (3): 252–9. doi:10.1006/geno.2000.6475. PMID 11401440.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.