YTHDC2

Protein-coding gene in humans
YTHDC2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2YU6

Identifiers
AliasesYTHDC2, CAHL, YTH domain containing 2, hYTHDC2
External IDsOMIM: 616530; MGI: 2448561; HomoloGene: 11265; GeneCards: YTHDC2; OMA:YTHDC2 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for YTHDC2
Genomic location for YTHDC2
Band5q22.2Start113,513,694 bp[1]
End113,595,285 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for YTHDC2
Genomic location for YTHDC2
Band18|18 B3Start44,960,813 bp[2]
End45,022,791 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • skin of thigh

  • skin of hip

  • hair follicle

  • tibia

  • Achilles tendon

  • Epithelium of choroid plexus

  • epithelium of nasopharynx

  • Brodmann area 23

  • germinal epithelium
Top expressed in
  • secondary oocyte

  • spermatocyte

  • zygote

  • cumulus cell

  • pineal gland

  • semi-lunar valve

  • aortic valve

  • lumbar spinal ganglion

  • endothelial cell of lymphatic vessel

  • tail of embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • protein binding
  • RNA polymerase binding
  • ATP binding
  • hydrolase activity
  • helicase activity
  • nucleic acid binding
  • ATP-dependent activity, acting on RNA
  • RNA binding
  • N6-methyladenosine-containing RNA binding
  • 3'-5' RNA helicase activity
Cellular component
  • endoplasmic reticulum
  • cytoplasm
  • nucleus
  • ribonucleoprotein granule
Biological process
  • response to tumor necrosis factor
  • RNA processing
  • response to interleukin-1
  • positive regulation by host of viral genome replication
  • spermatogenesis
  • spermatid development
  • cell differentiation
  • oogenesis
  • oocyte development
  • meiosis
  • germline cell cycle switching, mitotic to meiotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64848

240255

Ensembl

ENSG00000047188

ENSMUSG00000034653

UniProt

Q9H6S0

B2RR83

RefSeq (mRNA)

NM_022828
NM_001345975
NM_001345976

NM_001163013

RefSeq (protein)

NP_001332904
NP_001332905
NP_073739

NP_001156485

Location (UCSC)Chr 5: 113.51 – 113.6 MbChr 18: 44.96 – 45.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

YTH domain containing 2 is a protein that in humans is encoded by the YTHDC2 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000047188 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034653 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: YTH domain containing 2".

Further reading

  • Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR (April 2011). "Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients". Journal of Human Genetics. 56 (4): 316–23. doi:10.1038/jhg.2011.12. PMC 5825003. PMID 21326311.
  • Morohashi K, Sahara H, Watashi K, Iwabata K, Sunoki T, Kuramochi K, Takakusagi K, Miyashita H, Sato N, Tanabe A, Shimotohno K, Kobayashi S, Sakaguchi K, Sugawara F (April 2011). Klein R (ed.). "Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B". PLOS ONE. 6 (4): e18285. Bibcode:2011PLoSO...618285M. doi:10.1371/journal.pone.0018285. PMC 3084704. PMID 21559518.
  • Gano JJ, Simon JA (February 2010). "A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein". Molecular & Cellular Proteomics. 9 (2): 255–70. doi:10.1074/mcp.M900261-MCP200. PMC 2830838. PMID 19875381.


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