Protein-coding gene in the species Homo sapiens
| ZFYVE16 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | ZFYVE16, PPP1R69, zinc finger FYVE-type containing 16 |
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| External IDs | OMIM: 608880; MGI: 2145181; HomoloGene: 8826; GeneCards: ZFYVE16; OMA:ZFYVE16 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 5 (human)[1] |
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| | Band | 5q14.1 | Start | 80,408,013 bp[1] |
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| End | 80,483,379 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 13 (mouse)[2] |
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| | Band | 13|13 C3 | Start | 92,623,616 bp[2] |
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| End | 92,667,376 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - corpus callosum
- endothelial cell
- inferior ganglion of vagus nerve
- subthalamic nucleus
- pars reticulata
- inferior olivary nucleus
- superior vestibular nucleus
- C1 segment
- tibia
- external globus pallidus
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| | Top expressed in | - spermatocyte
- genital tubercle
- tail of embryo
- spermatid
- granulocyte
- choroid plexus of fourth ventricle
- ventricular zone
- cumulus cell
- urethra
- right kidney
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - 1-phosphatidylinositol binding
- protein binding
- phosphatidylinositol-3,4,5-trisphosphate binding
- metal ion binding
| | Cellular component | - endosome
- early endosome
- early endosome membrane
- intracellular membrane-bounded organelle
- membrane
- cytoplasm
- cytosol
| | Biological process | - regulation of endocytosis
- endosomal transport
- protein targeting to lysosome
- BMP signaling pathway
- signal transduction
- vesicle organization
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001105251
NM_001284236
NM_001284237
NM_014733
NM_001349434 |
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| RefSeq (protein) | |
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NP_001098721
NP_001271165
NP_001271166
NP_055548
NP_001336363 |
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| Location (UCSC) | Chr 5: 80.41 – 80.48 Mb | Chr 13: 92.62 – 92.67 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene.[5][6]
The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004).[supplied by OMIM][6]
In melanocytic cells ZFYVE16 gene expression may be regulated by MITF.[7]
Interactions
ZFYVE16 has been shown to interact with TOM1.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000039319 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021706 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Seet LF, Hong W (November 2001). "Endofin, an endosomal FYVE domain protein". The Journal of Biological Chemistry. 276 (45): 42445–54. doi:10.1074/jbc.M105917200. PMID 11546807.
- ^ a b "Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16".
- ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, et al. (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
- ^ Seet LF, Liu N, Hanson BJ, Hong W (February 2004). "Endofin recruits TOM1 to endosomes". The Journal of Biological Chemistry. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. PMID 14613930.
Further reading
- Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, et al. (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
- Seet LF, Liu N, Hanson BJ, Hong W (February 2004). "Endofin recruits TOM1 to endosomes". The Journal of Biological Chemistry. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. PMID 14613930.
- Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
- Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Zhao BM, Hoffmann FM (September 2006). "Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA". Molecular Biology of the Cell. 17 (9): 3819–31. doi:10.1091/mbc.E05-10-0990. PMC 1556379. PMID 16775010.
- Chen YG, Wang Z, Ma J, Zhang L, Lu Z (March 2007). "Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling". The Journal of Biological Chemistry. 282 (13): 9688–95. doi:10.1074/jbc.M611704200. PMID 17272273.
- Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, et al. (July 2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells". Proteomics. 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID 17570516. S2CID 23944956.
