ZMYND11

Protein-coding gene in the species Homo sapiens
ZMYND11
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4NS5, 5HDA

Identifiers
AliasesZMYND11, BRAM1, BS69, MRD30, zinc finger MYND-type containing 11
External IDsOMIM: 608668; MGI: 1913755; HomoloGene: 4828; GeneCards: ZMYND11; OMA:ZMYND11 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ZMYND11
Genomic location for ZMYND11
Band10p15.3Start134,465 bp[1]
End254,637 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for ZMYND11
Genomic location for ZMYND11
Band13|13 A1Start9,734,869 bp[2]
End9,815,366 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • optic nerve

  • caput epididymis

  • tail of epididymis

  • corpus epididymis

  • lactiferous duct

  • inferior ganglion of vagus nerve

  • corpus callosum

  • superior vestibular nucleus

  • postcentral gyrus

  • Brodmann area 46
Top expressed in
  • ciliary body

  • retinal pigment epithelium

  • iris

  • barrel cortex

  • conjunctival fornix

  • ureter

  • Region I of hippocampus proper

  • substantia nigra

  • Epithelium of choroid plexus

  • medullary collecting duct
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • chromatin binding
  • transcription coregulator activity
  • metal ion binding
  • protein binding
  • transcription corepressor activity
  • histone binding
  • double-stranded DNA binding
  • zinc ion binding
  • methylated histone binding
Cellular component
  • nucleoplasm
  • chromosome
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • negative regulation of extrinsic apoptotic signaling pathway
  • negative regulation of I-kappaB kinase/NF-kappaB signaling
  • transcription, DNA-templated
  • negative regulation of JNK cascade
  • cell cycle
  • cell population proliferation
  • viral process
  • regulation of transcription elongation from RNA polymerase II promoter
  • defense response to virus
  • negative regulation of nucleic acid-templated transcription
  • chromatin organization
  • negative regulation of transcription, DNA-templated
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10771

66505

Ensembl

ENSG00000015171

ENSMUSG00000021156

UniProt

Q15326

Q8R5C8

RefSeq (mRNA)
NM_001202464
NM_001202465
NM_001202466
NM_001202467
NM_001202468

NM_006624
NM_212479
NM_001330057

NM_001199141
NM_144516
NM_001347470
NM_001347471
NM_001347472

NM_001347473
NM_001347474
NM_001347476
NM_001347477
NM_001347479
NM_001347480
NM_001347481

RefSeq (protein)
NP_001189393
NP_001189394
NP_001189395
NP_001189396
NP_001189397

NP_001316986
NP_006615
NP_997644
NP_001357026
NP_001357027
NP_001357028
NP_001357029
NP_001357030
NP_001357031
NP_001357032
NP_001357033
NP_001357034
NP_001357035
NP_001357036
NP_001357037
NP_001357038
NP_001357039
NP_001357040
NP_001357041
NP_001357042
NP_001357043
NP_001357044
NP_001357045
NP_001357046
NP_001357047
NP_001357048
NP_001357049
NP_001357050
NP_001357051
NP_001357052
NP_001357053

NP_001186070
NP_001334399
NP_001334400
NP_001334401
NP_001334402

NP_001334403
NP_001334405
NP_001334406
NP_001334408
NP_001334409
NP_001334410
NP_653099

Location (UCSC)Chr 10: 0.13 – 0.25 MbChr 13: 9.73 – 9.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger MYND domain-containing protein 11 is a protein that in humans is encoded by the ZMYND11 gene.[5][6][7]

Function

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

Interactions

ZMYND11 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000015171 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021156 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, Bernards R (Jul 1995). "BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation". The EMBO Journal. 14 (13): 3159–69. doi:10.1002/j.1460-2075.1995.tb07318.x. PMC 394377. PMID 7621829.
  6. ^ Masselink H, Bernards R (Mar 2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene. 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313.
  7. ^ a b "Entrez Gene: ZMYND11 zinc finger, MYND domain containing 11".
  8. ^ a b Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (Apr 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660. S2CID 29818690.
  9. ^ Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/s0092-8674(03)00930-9. PMID 14651845. S2CID 18911371.
  10. ^ Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID 12894593.
  11. ^ Wen, Hong; Li, Yuanyuan; Xi, Yuanxin; Jiang, Shiming; Stratton, Sabrina; Peng, Danni; Tanaka, Kaori; Ren, Yongfeng; Xia, Zheng; Wu, Jun; Li, Bing; Barton, Michelle C.; Li, Wei; Li, Haitao; Shi, Xiaobing (2014). "ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression". Nature. 508 (7495): 263–268. doi:10.1038/nature13045. PMC 4142212. PMID 24590075.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (Apr 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660. S2CID 29818690.
  • Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (Apr 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". The Journal of Biological Chemistry. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
  • Ansieau S, Leutz A (Feb 2002). "The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif". The Journal of Biological Chemistry. 277 (7): 4906–10. doi:10.1074/jbc.M110078200. PMID 11733528.
  • Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID 12894593.
  • Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/S0092-8674(03)00930-9. PMID 14651845. S2CID 18911371.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Isobe T, Uchida C, Hattori T, Kitagawa K, Oda T, Kitagawa M (Jan 2006). "Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69". Biochemical and Biophysical Research Communications. 339 (1): 367–74. doi:10.1016/j.bbrc.2005.11.028. hdl:10271/294. PMID 16300738.
  • Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, Chui YL, Cui Y, Tao Q, Yamamoto M, Akira S, Wu Z (Jan 2006). "BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway". Molecular and Cellular Biology. 26 (2): 448–56. doi:10.1128/MCB.26.2.448-456.2006. PMC 1346911. PMID 16382137.
  • Velasco G, Grkovic S, Ansieau S (Jun 2006). "New insights into BS69 functions". The Journal of Biological Chemistry. 281 (24): 16546–50. doi:10.1074/jbc.M600573200. PMID 16565076.


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