ZNF364

Protein-coding gene in the species Homo sapiens
RNF115
Identifiers
AliasesRNF115, BCA2, ZNF364, ring finger protein 115, ZFP364, RABRING7
External IDsMGI: 1915095; HomoloGene: 69167; GeneCards: RNF115; OMA:RNF115 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RNF115
Genomic location for RNF115
Band1q21.1Start145,738,868 bp[1]
End145,824,095 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for RNF115
Genomic location for RNF115
Band3|3 F2.1Start96,634,980 bp[2]
End96,698,954 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • glutes

  • right ventricle

  • Skeletal muscle tissue of rectus abdominis

  • triceps brachii muscle

  • Skeletal muscle tissue of biceps brachii

  • paraflocculus of cerebellum

  • tail of epididymis

  • myocardium

  • vastus lateralis muscle

  • myocardium of left ventricle
Top expressed in
  • soleus muscle

  • substantia nigra

  • vastus lateralis muscle

  • barrel cortex

  • intercostal muscle

  • motor neuron

  • facial motor nucleus

  • trigeminal ganglion

  • tibialis anterior muscle

  • conjunctival fornix
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • ubiquitin protein ligase activity
  • ubiquitin-protein transferase activity
  • transferase activity
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • protein K63-linked ubiquitination
  • protein K48-linked ubiquitination
  • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
  • negative regulation of epidermal growth factor receptor signaling pathway
  • protein ubiquitination
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • protein autoubiquitination
  • protein polyubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

27246

67845

Ensembl

ENSG00000265491

ENSMUSG00000028098

UniProt

Q9Y4L5

Q9D0C1

RefSeq (mRNA)

NM_014455

NM_026406

RefSeq (protein)

NP_055270

NP_080682

Location (UCSC)Chr 1: 145.74 – 145.82 MbChr 3: 96.63 – 96.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 115 is a protein, that in humans, is encoded by the RNF115 gene.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000265491 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028098 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ZNF364 zinc finger protein 364".

Further reading

  • Burger A, Amemiya Y, Kitching R, Seth AK (2006). "Novel RING E3 ubiquitin ligases in breast cancer". Neoplasia. 8 (8): 689–95. doi:10.1593/neo.06469. PMC 1601945. PMID 16925951.
  • Sakane A, Hatakeyama S, Sasaki T (2007). "Involvement of Rabring7 in EGF receptor degradation as an E3 ligase". Biochem. Biophys. Res. Commun. 357 (4): 1058–64. doi:10.1016/j.bbrc.2007.04.052. PMID 17462600.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Burger AM, Gao Y, Amemiya Y, et al. (2006). "A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer". Cancer Res. 65 (22): 10401–12. doi:10.1158/0008-5472.CAN-05-2103. PMID 16288031.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mizuno K, Kitamura A, Sasaki T (2004). "Rabring7, a novel Rab7 target protein with a RING finger motif". Mol. Biol. Cell. 14 (9): 3741–52. doi:10.1091/mbc.E02-08-0495. PMC 196564. PMID 12972561.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.


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