PAX6 |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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2CUE, 6PAX |
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Identifiants |
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Aliases | PAX6 |
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IDs externes | OMIM: 607108 MGI: 97490 HomoloGene: 1212 GeneCards: PAX6 |
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Position du gène (Homme) |
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| Chr. | Chromosome 11 humain[1] |
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| Locus | 11p13 | Début | 31,784,779 bp[1] |
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Fin | 31,818,062 bp[1] |
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Position du gène (Souris) |
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| Chr. | Chromosome 2 (souris)[2] |
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| Locus | 2 E3|2 55.31 cM | Début | 105,499,245 bp[2] |
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Fin | 105,527,709 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - palpebral conjunctiva
- ventricular zone
- cellule bêta
- paraflocculus of cerebellum
- éminence ganglionnaire
- Vermis du cervelet
- right hemisphere of cerebellum
- pont
- external globus pallidus
- Region I of hippocampus proper
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| Fortement exprimé dans | - neural layer of retina
- corneal stroma
- ventricular zone
- cristallin
- épithélium cornéen
- iris
- epithelium of lens
- îlot de Langerhans
- corps ciliaire
- conjunctival fornix
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| Plus de données d'expression de référence |
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BioGPS | | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison protéique
- liaison ADN
- sequence-specific DNA binding
- ubiquitin-protein transferase activity
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- liaison de chromatine
- DNA-binding transcription factor activity
- transcription factor binding
- protein kinase binding
- ubiquitin protein ligase binding
- liaison d'histone acétyltransférase
- co-SMAD binding
- R-SMAD binding
- HMG box domain binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II core promoter sequence-specific DNA binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
| Composant cellulaire | - cytoplasme
- noyau
- nucléoplasme
- cytosol
- intracellulaire
| Processus biologique | - développement de l'œil
- blood vessel development
- morphogenèse d'un organe animal
- regulation of transcription, DNA-templated
- glucose homeostasis
- transcription, DNA-templated
- central nervous system development
- response to wounding
- différenciation cellulaire
- cornea development in camera-type eye
- negative regulation of neurogenesis
- vue
- iris morphogenesis
- développent d'un organisme multicellulaire
- neuron fate commitment
- Ubiquitination
- negative regulation of transcription by RNA polymerase II
- establishment of mitotic spindle orientation
- cell fate determination
- migration d'un neurone
- negative regulation of protein phosphorylation
- positive regulation of neuroblast proliferation
- lens development in camera-type eye
- régionalisation
- type B pancreatic cell differentiation
- pancreatic A cell development
- regulation of transcription by RNA polymerase II
- transcription by RNA polymerase II
- hedgehog
- axonogenesis
- Guidage axonal
- développement cérébral
- salivary gland morphogenesis
- negative regulation of cell population proliferation
- regulation of asymmetric cell division
- dorsal/ventral axis specification
- anterior/posterior pattern specification
- dorsal/ventral pattern formation
- régulation de l'expression des gènes
- positive regulation of gene expression
- pallium development
- oligodendrocyte cell fate specification
- cerebral cortex regionalization
- forebrain dorsal/ventral pattern formation
- commitment of neuronal cell to specific neuron type in forebrain
- forebrain-midbrain boundary formation
- telencephalon regionalization
- pituitary gland development
- habenula development
- signal transduction involved in regulation of gene expression
- keratinocyte differentiation
- regulation of cell migration
- positive regulation of epithelial cell differentiation
- forebrain development
- lacrimal gland development
- protein localization to organelle
- eye photoreceptor cell development
- camera-type eye development
- cell fate commitment
- negative regulation of neuron differentiation
- régulation positive de la transcription dépendante de l'ADN
- positive regulation of transcription by RNA polymerase II
- regulation of timing of cell differentiation
- embryonic camera-type eye morphogenesis
- astrocyte differentiation
- negative regulation of epithelial cell proliferation
- régulation de la neurogenèse
- retina development in camera-type eye
- cellular response to leukemia inhibitory factor
- negative regulation of neural precursor cell proliferation
- positive regulation of core promoter binding
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_000280 NM_001127612 NM_001258462 NM_001258463 NM_001258464
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NM_001258465 NM_001310158 NM_001310159 NM_001310160 NM_001310161 NM_001604 |
| NM_001244198 NM_001244200 NM_001244201 NM_001244202 NM_013627
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NM_001310144 NM_001310145 NM_001310146 |
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RefSeq (protéine) | NP_000271 NP_001121084 NP_001245391 NP_001245392 NP_001245393
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NP_001245394 NP_001297087 NP_001297088 NP_001297089 NP_001297090 NP_001595 NP_001355816 NP_001355817 NP_001355818 NP_001355819 NP_001355820 NP_001355821 NP_001355822 NP_001355823 NP_001355828 NP_001355829 NP_001355830 NP_001355831 NP_001355832 NP_001355833 NP_001355834 NP_001355835 NP_001355836 NP_001355837 NP_001355838 NP_001355839 NP_001355840 NP_001355841 NP_001355842 NP_001355843 NP_001355844 NP_001355845 NP_001355846 NP_001355847 NP_001355848 NP_001355849 NP_001355850 NP_001355851 NP_001355852 NP_001355853 NP_001355854 NP_001355855 NP_001355856 NP_001355857 NP_001355858 NP_001355859 |
| NP_001231127 NP_001231129 NP_001231130 NP_001231131 NP_001297073
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NP_001297074 NP_001297075 NP_038655 |
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Localisation (UCSC) | Chr 11: 31.78 – 31.82 Mb | Chr 2: 105.5 – 105.53 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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