| PML |
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| Structures disponibles |
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| PDB | Recherche d'orthologue: PDBe RCSB |
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| Identifiants PDB |
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1BOR, 2MVW, 2MWX, 4WJN, 4WJO |
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| Identifiants |
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| Aliases | PML |
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| IDs externes | OMIM: 102578 MGI: 104662 HomoloGene: 13245 GeneCards: PML |
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| Position du gène (Homme) |
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 | | Chr. | Chromosome 15 humain[1] |
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| | Locus | 15q24.1 | Début | 73,994,673 bp[1] |
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| Fin | 74,047,827 bp[1] |
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| Position du gène (Souris) |
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 | | Chr. | Chromosome 9 (souris)[2] |
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| | Locus | 9 B|9 31.63 cM | Début | 58,125,359 bp[2] |
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| Fin | 58,157,069 bp[2] |
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| Expression génétique |
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| Bgee | | Humain | Souris (orthologue) |
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| Fortement exprimé dans | - body of uterus
- upper lobe of left lung
- endocol
- ectocervix
- poumon droit
- subcutaneous adipose tissue
- right uterine tube
- apex of heart
- right lobe of thyroid gland
- left lobe of thyroid gland
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| | Fortement exprimé dans | - tail of embryo
- rate
- ganglion lymphatique
- fetal liver hematopoietic progenitor cell
- parotide
- ganglion mésentérique
- thymus
- moelle osseuse
- sang
- tibiofemoral joint
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| | Plus de données d'expression de référence |
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| BioGPS | |
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| Gene Ontology |
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| Fonction moléculaire | - SUMO binding
- cobalt ion binding
- liaison ion métal
- protein homodimerization activity
- zinc ion binding
- liaison protéique
- SMAD binding
- liaison ADN
- transcription coactivator activity
- protein heterodimerization activity
- ubiquitin protein ligase binding
- SUMO transferase activity
| | Composant cellulaire | - cytoplasme
- cytosol
- endosome
- membrane nucléaire
- membrane
- noyau
- matrice nucléaire
- nucléole
- réticulum endoplasmique
- early endosome membrane
- intracellulaire
- nucléoplasme
- PML body
- membrane du réticulum endoplasmique
- extrinsic component of endoplasmic reticulum membrane
- hétérochromatine
| | Processus biologique | - regulation of protein phosphorylation
- positive regulation of histone deacetylation
- intrinsic apoptotic signaling pathway in response to oxidative stress
- myeloid cell differentiation
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- negative regulation of telomere maintenance via telomerase
- processus rythmique
- interferon-gamma-mediated signaling pathway
- negative regulation of telomerase activity
- positive regulation of telomere maintenance
- sénescence cellulaire
- regulation of cell adhesion
- defense response to virus
- intrinsic apoptotic signaling pathway in response to DNA damage
- positive regulation of extrinsic apoptotic signaling pathway
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- transforming growth factor beta receptor signaling pathway
- proteasome-mediated ubiquitin-dependent protein catabolic process
- negative regulation of cell population proliferation
- positive regulation of defense response to virus by host
- apoptose
- response to cytokine
- cell fate commitment
- negative regulation of translation in response to oxidative stress
- regulation of transcription, DNA-templated
- common-partner SMAD protein phosphorylation
- branching involved in mammary gland duct morphogenesis
- extrinsic apoptotic signaling pathway
- positive regulation of fibroblast proliferation
- positive regulation of apoptotic signaling pathway
- endoplasmic reticulum calcium ion homeostasis
- transcription, DNA-templated
- PML body organization
- negative regulation of cell growth
- intrinsic apoptotic signaling pathway by p53 class mediator
- système immunitaire inné
- viral process
- response to gamma radiation
- response to UV
- regulation of calcium ion transport into cytosol
- positive regulation of protein localization to chromosome, telomeric region
- fibroblast migration
- adressage des protéines
- processus du système immunitaire
- protein stabilization
- positive regulation of apoptotic process involved in mammary gland involution
- circadian regulation of gene expression
- regulation of MHC class I biosynthetic process
- regulation of circadian rhythm
- negative regulation of transcription, DNA-templated
- maintenance of protein location in nucleus
- cellular response to interleukin-4
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- response to hypoxia
- regulation of double-strand break repair
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- retinoic acid receptor signaling pathway
- negative regulation of angiogenesis
- negative regulation of ubiquitin-dependent protein catabolic process
- entrainment of circadian clock by photoperiod
- negative regulation of mitotic cell cycle
- positive regulation of MHC class I biosynthetic process
- positive regulation of transcription by RNA polymerase II
- regulation of signal transduction by p53 class mediator
- cellular response to leukemia inhibitory factor
- protein import into nucleus
- protein-containing complex assembly
- positive regulation of nucleic acid-templated transcription
- Sumoylation
| | Sources:Amigo / QuickGO |
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| Orthologues |
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| Espèces | Homme | Souris |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | NM_033250
NM_002675
NM_033238
NM_033239
NM_033240
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NM_033244
NM_033246
NM_033247
NM_033249 |
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NM_008884
NM_178087
NM_001311088 |
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| RefSeq (protéine) | NP_002666
NP_150241
NP_150242
NP_150243
NP_150247
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NP_150249
NP_150250
NP_150252
NP_150253 |
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NP_001298017
NP_032910
NP_835188 |
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| Localisation (UCSC) | Chr 15: 73.99 – 74.05 Mb | Chr 9: 58.13 – 58.16 Mb |
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| Publication PubMed | [3] | [4] |
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| Wikidata |
| Voir/Editer Humain | Voir/Editer Souris |
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