SPI1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/7b/Protein_SPI1_PDB_1pue.png/250px-Protein_SPI1_PDB_1pue.png) |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants |
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Aliases | SPI1 |
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IDs externes | OMIM: 165170 MGI: 98282 HomoloGene: 2346 GeneCards: SPI1 |
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Position du gène (Homme) |
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![Chromosome 11 humain](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/300px-Ideogram_human_chromosome_11.svg.png) | Chr. | Chromosome 11 humain[1] |
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| Locus | 11p11.2 | Début | 47,354,860 bp[1] |
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Fin | 47,378,547 bp[1] |
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Position du gène (Souris) |
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![Chromosome 2 (souris)](//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Ideogram_house_mouse_chromosome_2.svg/260px-Ideogram_house_mouse_chromosome_2.svg.png) | Chr. | Chromosome 2 (souris)[2] |
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| Locus | 2 E1|2 50.44 cM | Début | 90,912,735 bp[2] |
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Fin | 90,946,101 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - granulocyte
- monocyte
- poumon droit
- upper lobe of left lung
- rate
- sang
- cellule de la moelle osseuse
- appendice iléo-cæcal
- artère coronaire droite
- ganglion lymphatique
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| Fortement exprimé dans | - granulocyte
- tibiofemoral joint
- ganglion mésentérique
- stroma of bone marrow
- rate
- sang
- medulla of thymus
- embryon
- lèvre
- articulation talo-crurale
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| Plus de données d'expression de référence |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/PBB_GE_SPI1_205312_at_fs.png/250px-PBB_GE_SPI1_205312_at_fs.png) | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison ADN
- sequence-specific DNA binding
- DNA-binding transcription activator activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- liaison protéique
- liaison ARN
- transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
- DNA-binding transcription factor activity
- NFAT protein binding
- DNA-binding transcription factor activity, RNA polymerase II-specific
- transcription factor binding
| Composant cellulaire | - noyau
- nucléoplasme
- transcription regulator complex
| Processus biologique | - myeloid leukocyte differentiation
- regulation of transcription, DNA-templated
- cellular response to ethanol
- somatic stem cell population maintenance
- lymphocyte differentiation
- regulation of erythrocyte differentiation
- myeloid dendritic cell differentiation
- negative regulation of transcription by RNA polymerase II
- negative regulation of MHC class II biosynthetic process
- lymphoid progenitor cell differentiation
- transcription, DNA-templated
- macrophage differentiation
- anatomical structure regression
- negative regulation of histone H4 acetylation
- negative regulation of gene expression, epigenetic
- vasculature development
- granulocyte differentiation
- apoptotic process involved in blood vessel morphogenesis
- histone H3 acetylation
- erythrocyte differentiation
- hypermethylation of CpG island
- positive regulation of pri-miRNA transcription by RNA polymerase II
- positive regulation of transcription by RNA polymerase II
- negative regulation of transcription, DNA-templated
- régulation positive de la transcription dépendante de l'ADN
- regulation of transcription by RNA polymerase II
- pri-miRNA transcription by RNA polymerase II
- différenciation cellulaire
- interleukin-6-mediated signaling pathway
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_011355 NM_001378898 NM_001378899 |
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RefSeq (protéine) | | |
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NP_035485 NP_001365827 NP_001365828 |
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Localisation (UCSC) | Chr 11: 47.35 – 47.38 Mb | Chr 2: 90.91 – 90.95 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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