AGTRAP

Struktur yang tersedia

PDB

Pencarian Ortolog: PDBe RCSB

Daftar kode id PDB
1ZV0, 4YAY

Pengidentifikasi

Alias

AGTRAP, ATRAP, angiotensin II receptor associated protein

ID eksternal

OMIM: 608729 MGI: 1339977 HomoloGene: 7621 GeneCards: AGTRAP

Ontologi gen
Fungsi molekuler	• GO:0001948, GO:0016582 Ikatan protein plasma • angiotensin type II receptor activity
Komponen seluler	• komponen integral membran • Golgi membrane • Membran sel • badan Golgi • cell cortex • endoplasmic reticulum membrane • cytoplasmic vesicle membrane • intracellular membrane-bounded organelle • Retikulum endoplasma • membran • GO:0016023 cytoplasmic vesicle • nucleoplasm • sitosol
Proses biologis	• regulation of blood pressure • angiotensin-activated signaling pathway • respons terhadap hipoksia
Sumber:Amigo / QuickGO

Ortolog

Spesies

Manusia

Tikus

Entrez


57085


11610

Ensembl


ENSG00000177674


ENSMUSG00000029007

UniProt


Q6RW13


Q9WVK0

RefSeq (mRNA)


NM_001040194 NM_001040195 NM_001040196 NM_001040197 NM_020350


NM_001301281 NM_009642

RefSeq (protein)


NP_001035284 NP_001035285 NP_001035286 NP_001035287 NP_065083


NP_001288210 NP_033772

Lokasi (UCSC)

n/a

Pencarian PubMed

^[1]

^[2]

Wikidata

Lihat/Sunting Manusia

Lihat/Sunting Tikus

Type-1 angiotensin II receptor-associated protein adalah protein yang pada manusia dikodekan oleh gen AGTRAP.^[3]^[4]

Gen ini mengkodekan protein transmembran yang terlokalisasi pada membran plasma dan struktur vesikuler perinuklear. Produk gen berinteraksi dengan reseptor angiotensin II tipe I dan secara negatif mengatur pensinyalan angiotensin II. Penyambungan alternatif gen ini menghasilkan beberapa varian transkrip yang mengkodekan isoform berbeda.^[4]

Interaksi

AGTRAP telah terbukti berinteraksi dengan GNB2L1.^[3]

Referensi

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y (Dec 2001). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int J Biochem Cell Biol. 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. PMID 11733189.
^ ^a ^b "Entrez Gene: AGTRAP angiotensin II receptor-associated protein".

Pranala luar

Lokasi genom AGTRAP manusia dan halaman rincian gen AGTRAP dalam UCSC Genome Browser.

Bacaan lanjutan

Daviet L, Lehtonen JY, Tamura K, et al. (1999). "Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor". J. Biol. Chem. 274 (24): 17058–62. doi:10.1074/jbc.274.24.17058 . PMID 10358057.
Cui T, Nakagami H, Iwai M, et al. (2001). "ATRAP, novel AT1 receptor associated protein, enhances internalization of AT1 receptor and inhibits vascular smooth muscle cell growth". Biochem. Biophys. Res. Commun. 279 (3): 938–41. doi:10.1006/bbrc.2000.4055. PMID 11162453.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 171–84. PMID 12107413.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241 . PMID 12477932.
Lopez-Ilasaca M, Liu X, Tamura K, Dzau VJ (2004). "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling". Mol. Biol. Cell. 14 (12): 5038–50. doi:10.1091/mbc.E03-06-0383. PMC 284805 . PMID 12960423.
Guo DF, Chenier I, Tardif V, et al. (2003). "Type 1 angiotensin II receptor-associated protein ARAP1 binds and recycles the receptor to the plasma membrane". Biochem. Biophys. Res. Commun. 310 (4): 1254–65. doi:10.1016/j.bbrc.2003.09.154. PMID 14559250.
Guo DF, Tardif V, Ghelima K, et al. (2004). "A novel angiotensin II type 1 receptor-associated protein induces cellular hypertrophy in rat vascular smooth muscle and renal proximal tubular cells". J. Biol. Chem. 279 (20): 21109–20. doi:10.1074/jbc.M401544200 . PMID 14985364.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Guo S, Lopez-Ilasaca M, Dzau VJ (2005). "Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation". J. Biol. Chem. 280 (13): 12536–41. doi:10.1074/jbc.M500296200 . PMID 15668245.
Tanaka Y, Tamura K, Koide Y, et al. (2005). "The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy". FEBS Lett. 579 (7): 1579–86. doi:10.1016/j.febslet.2005.01.068 . PMID 15757644.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. Parameter |s2cid= yang tidak diketahui akan diabaikan (bantuan)
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727 . PMID 16710414.