MAP1B

Proteina associata ai microtubuli 1B
Gene
HUGO	MAP1B ; DKFZp686E1099; DKFZp686F1345; FLJ38954; FUTSCH; MAP5
Entrez	4131
Locus	Chr. 5 q13
Proteina
OMIM	157129
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La proteina associata ai microtubuli 1B è una proteina che nell'uomo è codificata dal gene MAP1B.^[1]^[2]

Questo gene codifica una proteina che appartiene alla famiglia delle proteina associate ai microtubuli. La proteine di questa famiglia si pensa siano implicate nella costruzione del microtubulo, per questo sono un passaggio essenziale per la neurogenesi. Il prodotto di questo gene è un polipeptide precursore che presumibilmente subisce processi proteolitici per generare la catena pesante finale MAP1B e la catena leggera LC1. Studi sul gene knockout del gene MAP1B di topo suggeriscono un importante ruolo nello sviluppo e funzionalità del sistema nervoso. Due splicing alternativi producono delle varianti.^[2]

Interazioni

MAP1B è stato dimostrato interagire con ANP32A^[3] e RASSF1^[4].

Note

^ Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM, Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13, in Proc Natl Acad Sci U S A, vol. 88, n. 17, ottobre 1991, pp. 7873-6, PMID 1881920, PMC 52406.
^ ^a ^b Entrez Gene: MAP1B microtubule-associated protein 1B, su ncbi.nlm.nih.gov.
^ Puneet Opal, Garcia Jesus J, Propst Friedrich, Matilla Antoni, Orr Harry T, Zoghbi Huda Y, Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis, in J. Biol. Chem., vol. 278, n. 36, United States, settembre 2003, pp. 34691-9, DOI:10.1074/jbc.M302785200, ISSN 0021-9258 (WC · ACNP), PMID 12807913.
^ Ashraf Dallol, Agathanggelou Angelo, Fenton Sarah L, Ahmed-Choudhury Jalal, Hesson Luke, Vos Michele D, Clark Geoffrey J, Downward Julian, Maher Eamonn R, Latif Farida, RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics, in Cancer Res., vol. 64, n. 12, United States, giugno 2004, pp. 4112-6, DOI:10.1158/0008-5472.CAN-04-0267, ISSN 0008-5472 (WC · ACNP), PMID 15205320.

Bibliografia

Hammarback JA, Obar RA, Hughes SM, Vallee RB, MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain., in Neuron, vol. 7, n. 1, 1991, pp. 129–39, DOI:10.1016/0896-6273(91)90081-A, PMID 1712602.
Schoenfeld TA, McKerracher L, Obar R, Vallee RB, MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS., in J. Neurosci., vol. 9, n. 5, 1989, pp. 1712–30, PMID 2470876.
Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J, Role of phosphorylated MAPlB in neuritogenesis., in Cell Biol. Int., vol. 18, n. 5, 1994, pp. 309–14, DOI:10.1006/cbir.1994.1079, PMID 7519512.
Lien LL, Feener CA, Fischbach N, Kunkel LM, Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15., in Genomics, vol. 22, n. 2, 1995, pp. 273–80, DOI:10.1006/geno.1994.1384, PMID 7806212.
Ohyu J, Takashima S, Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions., in Brain Dev., vol. 20, n. 1, 1998, pp. 22–6, DOI:10.1016/S0387-7604(97)00088-0, PMID 9533556.
Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC, Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium., in J. Cell. Sci., 111 ( Pt 10), 1998, pp. 1351–61, PMID 9570753.
Tögel M, Wiche G, Propst F, Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain., in J. Cell Biol., vol. 143, n. 3, 1998, pp. 695–707, DOI:10.1083/jcb.143.3.695, PMID 9813091.
Hanley JG, Koulen P, Bedford F, et al., The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses., in Nature, vol. 397, n. 6714, 1999, pp. 66–9, DOI:10.1038/16258, PMID 9892354.
Jensen PH, Islam K, Kenney J, et al., Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments., in J. Biol. Chem., vol. 275, n. 28, 2000, pp. 21500–7, DOI:10.1074/jbc.M000099200, PMID 10764738.
Tanner SL, Franzen R, Jaffe H, Quarles RH, Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein., in J. Neurochem., vol. 75, n. 2, 2000, pp. 553–62, DOI:10.1046/j.1471-4159.2000.0750553.x, PMID 10899930.
Mei X, Sweatt AJ, Hammarback JA, <56::AID-JNR6>3.0.CO;2-# Regulation of microtubule-associated protein 1B (MAP1B) subunit composition., in J. Neurosci. Res., vol. 62, n. 1, 2000, pp. 56–64, DOI:10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-#, PMID 11002287.
Billups D, Hanley JG, Orme M, et al., GABAC receptor sensitivity is modulated by interaction with MAP1B., in J. Neurosci., vol. 20, n. 23, 2001, pp. 8643–50, PMID 11102469.
Franzen R, Tanner SL, Dashiell SM, et al., Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein., in J. Cell Biol., vol. 155, n. 6, 2002, pp. 893–8, DOI:10.1083/jcb.200108137, PMID 11733546.
Ding J, Liu JJ, Kowal AS, et al., Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin., in J. Cell Biol., vol. 158, n. 3, 2002, pp. 427–33, DOI:10.1083/jcb.200202055, PMID 12147674.
Strausberg RL, Feingold EA, Grouse LH, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., in Proc. Natl. Acad. Sci. U.S.A., vol. 99, n. 26, 2003, pp. 16899–903, DOI:10.1073/pnas.242603899, PMID 12477932.
Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA, Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region., in Biomol. Eng., vol. 20, n. 3, 2004, pp. 91–6, DOI:10.1016/S1389-0344(03)00003-0, PMID 12684070.
Chang L, Jones Y, Ellisman MH, et al., JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins., in Dev. Cell, vol. 4, n. 4, 2003, pp. 521–33, DOI:10.1016/S1534-5807(03)00094-7, PMID 12689591.
Opal P, Garcia JJ, Propst F, et al., Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis., in J. Biol. Chem., vol. 278, n. 36, 2003, pp. 34691–9, DOI:10.1074/jbc.M302785200, PMID 12807913.
Ota T, Suzuki Y, Nishikawa T, et al., Complete sequencing and characterization of 21,243 full-length human cDNAs., in Nat. Genet., vol. 36, n. 1, 2004, pp. 40–5, DOI:10.1038/ng1285, PMID 14702039.