カテプシンW

カテプシンW(Cathepsin W)は、ヒトではCTSW遺伝子でコードされるタンパク質である^[1]^[2]^[3]。

この遺伝子でコードされるタンパク質はペプチダーゼC1ファミリーに分類され、T細胞の細胞溶解反応を制御する特殊な機能を持っていると考えられている。ナチュラルキラー細胞や細胞傷害性T細胞の小胞体内の膜と結合して観察される。この遺伝子の発現は、インターロイキン-2によりアップレギュレートされる^[3]。

出典

^ “Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes”. FEBS Lett 405 (3): 253-9. (May 1997). doi:10.1016/S0014-5793(97)00118-X. PMID 9108299.
^ “Genomic structure, chromosomal localization, and expression of human cathepsin W”. Biochem Biophys Res Commun 248 (2): 255-61. (Aug 1998). doi:10.1006/bbrc.1998.8954. PMID 9675123.
^ ^a ^b “Entrez Gene: CTSW cathepsin W”. 2022年10月14日閲覧。

関連文献

“The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121-7. (2004). doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/.
“Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene.”. Biochem. Biophys. Res. Commun. 321 (4): 975-80. (2004). doi:10.1016/j.bbrc.2004.07.056. PMID 15358123.
“Signal peptide prediction based on analysis of experimentally verified cleavage sites.”. Protein Sci. 13 (10): 2819-24. (2005). doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2286551/.
“Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. (2003). Bibcode: 2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/.
“Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract.”. Biol. Chem. 383 (7-8): 1285-9. (2003). doi:10.1515/BC.2002.144. PMID 12437118.
“Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum.”. J. Immunol. 167 (4): 2172-8. (2001). doi:10.4049/jimmunol.167.4.2172. PMID 11490002.
“Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like cysteine proteases.”. Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 477: 271-80. (2000). doi:10.1007/0-306-46826-3_29. ISBN 0-306-46383-0. PMID 10849754.
“Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes.”. Int. J. Biochem. Cell Biol. 32 (3): 373-84. (2000). doi:10.1016/S1357-2725(99)00129-6. PMID 10716634.
“Human cathepsins F and W: A new subgroup of cathepsins.”. Biochem. Biophys. Res. Commun. 259 (2): 401-7. (1999). doi:10.1006/bbrc.1999.0700. PMID 10362521.
“Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase.”. Leukemia 12 (11): 1771-81. (1998). doi:10.1038/sj.leu.2401164. PMID 9823953.