BHLHB2

BHLHE40
식별자
다른 이름BHLHE40, BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14, basic helix-loop-helix family member e40, Clast5, SHARP2
외부 IDOMIM: 604256 MGI: 1097714 HomoloGene: 2722 GeneCards: BHLHE40
유전자 위치 (인간)
3번 염색체
염색체3번 염색체[1]
3번 염색체
BHLHE40의 유전자 위치
BHLHE40의 유전자 위치
자리3p26.1시작4,979,437 bp[1]
끝4,985,323 bp[1]
유전자 위치 (쥐)
6번 염색체 (쥐)
염색체6번 염색체 (쥐)[2]
6번 염색체 (쥐)
BHLHE40의 유전자 위치
BHLHE40의 유전자 위치
자리6|6 E2시작108,637,590 bp[2]
끝108,643,886 bp[2]
RNA 발현 패턴
Bgee
인간쥐(동원체)
최상위 발현
  • saphenous vein

  • 대정맥

  • 베타 세포

  • mucosa of pharynx

  • synovial joint

  • 심장막

  • tail of epididymis

  • gastric mucosa

  • mucosa of paranasal sinus

  • 음경
최상위 발현
  • 발목

  • decidua

  • 장딴지빗근

  • 긴발가락폄근

  • 자궁경부

  • 홍채

  • left lobe of liver

  • 앞정강근

  • 모양체

  • 위팔세갈래근
추가 참조 발현 데이터
BioGPS


추가 참조 발현 데이터
유전자 온톨로지
분자 함수
  • DNA 결합
  • protein dimerization activity
  • protein homodimerization activity
  • MRF binding
  • transcription corepressor activity
  • protein domain specific binding
  • DNA-binding transcription factor activity
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • bHLH transcription factor binding
  • E-box binding
  • 단백질 결합
  • protein heterodimerization activity
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
  • transcription factor binding
  • sequence-specific DNA binding
  • sequence-specific double-stranded DNA binding
세포 성분
  • 세포질
  • 세포핵
  • nuclear body
생물학적 과정
  • DNA를 주형으로 한 전사의 조절
  • response to light stimulus
  • rhythmic process
  • negative regulation of transcription by RNA polymerase II
  • circadian regulation of gene expression
  • DNA를 주형으로 한 전사
  • negative regulation of DNA-binding transcription factor activity
  • negative regulation of transcription, DNA-templated
  • entrainment of circadian clock by photoperiod
  • 일주기 생체 리듬
  • somitogenesis
  • Notch signaling pathway
  • 세포 분화
  • regulation of neurogenesis
출처: Amigo / QuickGO
동원체
종인간쥐
앙트레

8553

20893

앙상블

ENSG00000134107

ENSMUSG00000030103

유니프롯

O14503

O35185

RefSeq (mRNA)

NM_003670

NM_011498

RefSeq(단백질)

NP_003661

NP_035628

위치(UCSC)Chr 3: 4.98 – 4.99 MbChr 6: 108.64 – 108.64 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집쥐 보기/편집

클래스 E 기본 나선-루프-나선 단백질 40(BHLHB2)은 인간에서 BHLHE40 유전자에 의해 암호화 된 단백질이다.[5][6][7][8]

기능

DEC1은 다양한 조직에서 발현된 기본 나선-루프-나선 단백질을 암호화한다. 연골 세포에서의 발현은 Bt2cAMP의 첨가에 반응한다. 분화된 배아 연골 세포 발현 유전자 1은 세포 분화의 조절에 관여하는 것으로 여겨진다.[8]

각주

  1. ↑ 가 나 다 GRCh38: Ensembl release 89: ENSG00000134107 - 앙상블, May 2017
  2. ↑ 가 나 다 GRCm38: Ensembl release 89: ENSMUSG00000030103 - 앙상블, May 2017
  3. ↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》. 
  4. ↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》. 
  5. ↑ “Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes”. 《Biochemical and Biophysical Research Communications》 236 (2): 294–8. Jul 1997. doi:10.1006/bbrc.1997.6960. PMID 9240428. 
  6. ↑ “Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization”. 《Cytogenetics and Cell Genetics》 85 (3–4): 254–5. Oct 1999. doi:10.1159/000015305. PMID 10449910. 
  7. ↑ “Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation”. 《Differentiation; Research in Biological Diversity》 76 (9): 1006–22. Nov 2008. doi:10.1111/j.1432-0436.2008.00285.x. PMC 5728086. PMID 18557763. 
  8. ↑ 가 나 “Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2”. 

추가 자료

  • “Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2”. 《Journal of Biochemistry》 129 (3): 391–6. Mar 2001. doi:10.1093/oxfordjournals.jbchem.a002869. PMID 11226878. 
  • “Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway”. 《The Journal of Biological Chemistry》 276 (18): 15306–15. May 2001. doi:10.1074/jbc.M010516200. PMID 11278694. 
  • “Defective T cell activation and autoimmune disorder in Stra13-deficient mice”. 《Nature Immunology》 2 (11): 1040–7. Nov 2001. doi:10.1038/ni721. PMID 11668339. 
  • “Identification of genes differentially induced by hypoxia in pancreatic cancer cells”. 《Biochemical and Biophysical Research Communications》 288 (4): 882–6. Nov 2001. doi:10.1006/bbrc.2001.5867. PMID 11688991. 
  • “Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation”. 《The Biochemical Journal》 367 (Pt 2): 413–22. Oct 2002. doi:10.1042/BJ20020514. PMC 1222902. PMID 12119049. 
  • “Stra13 homodimers repress transcription through class B E-box elements”. 《The Journal of Biological Chemistry》 277 (48): 46544–51. Nov 2002. doi:10.1074/jbc.M111652200. PMID 12297495. 
  • “Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes”. 《The Journal of Biological Chemistry》 277 (49): 47014–21. Dec 2002. doi:10.1074/jbc.M204938200. PMID 12354771. 
  • “Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages”. 《The Journal of Biological Chemistry》 277 (51): 50112–20. Dec 2002. doi:10.1074/jbc.M206771200. PMID 12384505. 
  • “Dec1 and Dec2 are regulators of the mammalian molecular clock”. 《Nature》 419 (6909): 841–4. Oct 2002. doi:10.1038/nature01123. PMID 12397359. 
  • “DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter”. 《The Journal of Biological Chemistry》 278 (19): 16899–907. May 2003. doi:10.1074/jbc.M300596200. PMID 12624110. 
  • “DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer”. 《The Journal of Pathology》 200 (2): 222–8. Jun 2003. doi:10.1002/path.1330. PMID 12754744. 
  • “STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets”. 《Journal of Molecular Biology》 340 (4): 641–53. Jul 2004. doi:10.1016/j.jmb.2004.05.025. PMID 15223310. 
  • “Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1”. 《European Journal of Biochemistry / FEBS》 271 (22): 4409–19. Nov 2004. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782. 
  • “Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins”. 《Cellular and Molecular Life Sciences》 62 (4): 471–84. Feb 2005. doi:10.1007/s00018-004-4423-2. PMID 15719173. 
  • “STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker”. 《Journal of Medical Genetics》 42 (7): 565–76. Jul 2005. doi:10.1136/jmg.2004.029835. PMC 1736099. PMID 15994878. 
  • “A human protein-protein interaction network: a resource for annotating the proteome”. 《Cell》 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.