CD154

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CD154
Renderização com base em PDB 1aly.
Estruturas disponíveis
PDB Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB

1ALY, 1I9R, 3LKJ, 3QD6

Identificadores
Símbolos CD40LG; CD154; CD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP; gp39; hCD40L
IDs externos OMIM: 300386 MGI: 88337 HomoloGene: 56 GeneCards: CD40LG Gene
Ontologia do gene
Função molecular •cytokine activity
•tumor necrosis factor receptor binding
•CD40 receptor binding
Componente celular •extracellular space
•membrana plasmática
•integral to plasma membrane
•external side of plasma membrane
•integral to membrane
Processo biológico •positive regulation of immune response to tumor cell
•anti-apoptosis
•resposta inflamatória
•leukocyte cell-cell adhesion
•platelet activation
•B cell differentiation
•positive regulation of B cell proliferation
•positive regulation of interferon-gamma production
•positive regulation of interleukin-10 production
•positive regulation of interleukin-12 production
•B cell proliferation
•isotype switching
•positive regulation of MHC class II biosynthetic process
•immunoglobulin secretion
•regulation of immune response
•regulation of immunoglobulin secretion
•positive regulation of endothelial cell apoptotic process
Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies Humano Rato
Entrez 959 21947
Ensembl ENSG00000102245 ENSMUSG00000031132
UniProt P29965 P27548
RefSeq (mRNA) NM_000074.2 NM_011616.2
RefSeq (proteína) NP_000065.1 NP_035746.2
Localização (UCSC) Chr X:
135.73 – 135.74 Mb		 Chr X:
57.21 – 57.22 Mb
Busca PubMed [1] [2]
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CD154 é uma proteína que é expressa primeiramente em células T activadas e é membro da superfamília TNF. Liga-se à CD40 em células apresentadoras de antigénios, o que leva a muitos efeitos dependendo do tipo de célula-alvo.

A proteína é expressa na superfície das células T.

Leitura de apoio

  • Parham, Peter (2004). The Immune System 2nd ed. [S.l.]: Garland Science. pp. 169–173. ISBN 0-8153-4093-1 
  • Tong AW, Stone MJ (1997). «CD40 and the effect of anti-CD40-binding on human multiple myeloma clonogenicity.». Leuk. Lymphoma. 21 (1-2): 1–8. PMID 8907262. doi:10.3109/10428199609067572 
  • van Kooten C, Banchereau J (2000). «CD40-CD40 ligand.». J. Leukoc. Biol. 67 (1): 2–17. PMID 10647992 
  • Schattner EJ (2003). «CD40 ligand in CLL pathogenesis and therapy.». Leuk. Lymphoma. 37 (5-6): 461–72. PMID 11042507 
  • Bhushan A, Covey LR (2002). «CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes.». Immunol. Res. 24 (3): 311–24. PMID 11817328. doi:10.1385/IR:24:3:311 
  • Cheng G, Schoenberger SP (2002). «CD40 signaling and autoimmunity.». Curr. Dir. Autoimmun. 5: 51–61. PMID 11826760 
  • Subauste CS (2002). «CD154 and type-1 cytokine response: from hyper IgM syndrome to human immunodeficiency virus infection.». J. Infect. Dis. 185 Suppl 1: S83–9. PMID 11865444. doi:10.1086/338003 
  • Kornbluth RS (2003). «An expanding role for CD40L and other tumor necrosis factor superfamily ligands in HIV infection.». J. Hematother. Stem Cell Res. 11 (5): 787–801. PMID 12427285. doi:10.1089/152581602760404595 
  • Xu Y, Song G (2005). «The role of CD40-CD154 interaction in cell immunoregulation.». J. Biomed. Sci. 11 (4): 426–38. PMID 15153777. doi:10.1159/000077892