DYNLT1

DYNLT1
Identificadores
Nomes alternativosDYNLT1, Cadeia leve de dineína tipo Tctex 1, TCTEX1
IDs externosOMIM: 601554 HomoloGene: 4754 GeneCards: DYNLT1
Ontologia genética
Função molecular• GO:0001948, GO:0016582 ligação a proteínas plasmáticas
• identical protein binding
• cytoskeletal motor activity
• protein C-terminus binding
Componente celular• citoplasma
• complexo de Golgi
• secretory vesicle
• fuso mitótico
• dynein complex
• cytoplasmic microtubule
• microtúbulo
• citoesqueleto
• host cell
• extracellular region
• cytoplasmic dynein complex
• secretory granule lumen
• ficolin-1-rich granule lumen
• mitocôndria
• lamellipodium
• neuronal cell body
• axonal growth cone
Processo biológico• intracellular transport of viral protein in host cell
• regulation of G protein-coupled receptor signaling pathway
• negative regulation of neurogenesis
• nervous system development
• divisão celular
• establishment of mitotic spindle orientation
• microtubule-dependent intracellular transport of viral material towards nucleus
• viral entry into host cell
• ciclo celular
• GO:0022415 viral process
• transport of viral material towards nucleus
• neutrophil degranulation
• positive regulation of neuron projection development
• dendrite development
• positive regulation of Rac protein signal transduction
• negative regulation of mitochondrial membrane permeability
• GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity
• neuron projection morphogenesis
• regulation of cytoskeleton organization
• negative regulation of cell death
• axon development
Sources:Amigo / QuickGO
Padrão de expressão RNA
Mais dados de referência de expressão
Ortólogos
EspécieHumanoRato
Entrez

6993

n/a

Ensembl

ENSG00000146425

n/a

UniProt

P63172

n/a

RefSeq (mRNA)

NM_006519
NM_001291602
NM_001291603

n/a

RefSeq (proteína)

NP_001278531
NP_001278532
NP_006510

n/a

Localização (UCSC)n/an/a
Pesquisa PubMed[1]n/a
Wikidata
Ver/Editar Humano

A Cadeia leve de dineína tipo TCTEX1 é uma proteína que em humanos é codificada pelo gene DYNLT1.[2][3][4]

A dineína citoplasmática é o principal complexo de proteína motora responsável por processos móveis baseados em microtúbulos e de extremidade inferior. Cada complexo de dineína consiste em 2 cadeias pesadas que possuem ATPase e atividades motoras, além de um grupo de polipeptídeos acessórios. TCTEX1 é uma cadeia leve de dineína envolvida na ligação de carga (Chuang et al., 2005).[4]

Referências

  1. ↑ «Human PubMed Reference:» 
  2. ↑ Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (julho de 1996). «Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q». Cytogenet Cell Genet. 73 (1–2): 153–6. PMID 8646886. doi:10.1159/000134329 
  3. ↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (novembro de 2005). «Cytoplasmic dynein nomenclature». J Cell Biol. 171 (3): 411–3. PMC 2171247Acessível livremente. PMID 16260502. doi:10.1083/jcb.200508078 
  4. ↑ a b «Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1» 

Leitura adicional

  • Tete R, de Montgolfier R, Piante M (1971). «[Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography]». Journal de Médecine de Lyon. 52 (192): 1523–6 passim. PMID 5503857 
  • King SM, Dillman JF, Benashski SE, et al. (1997). «The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein.». J. Biol. Chem. 271 (50): 32281–7. PMID 8943288. doi:10.1074/jbc.271.50.32281 
  • Nagano F, Orita S, Sasaki T, et al. (1998). «Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport.». J. Biol. Chem. 273 (46): 30065–8. PMID 9804756. doi:10.1074/jbc.273.46.30065 
  • Strovel ET, Wu D, Sussman DJ (2000). «Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.». J. Biol. Chem. 275 (4): 2399–403. PMID 10644691. doi:10.1074/jbc.275.4.2399 
  • Mueller S, Cao X, Welker R, Wimmer E (2002). «Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.». J. Biol. Chem. 277 (10): 7897–904. PMID 11751937. doi:10.1074/jbc.M111937200 
  • Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). «Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74.». Int. J. Biochem. Cell Biol. 34 (9): 1059–70. PMID 12009301. doi:10.1016/S1357-2725(02)00026-2 
  • Nadano D, Nakayama J, Matsuzawa S, et al. (2002). «Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton.». Biochem. J. 364 (Pt 3): 669–77. PMC 1222615Acessível livremente. PMID 12049630. doi:10.1042/BJ20011836 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241Acessível livremente. PMID 12477932. doi:10.1073/pnas.242603899 
  • Machado RD, Rudarakanchana N, Atkinson C, et al. (2004). «Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.». Hum. Mol. Genet. 12 (24): 3277–86. PMID 14583445. doi:10.1093/hmg/ddg365 
  • Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). «Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.». J. Biol. Chem. 279 (27): 28522–30. PMID 15117959. doi:10.1074/jbc.M311671200 
  • Ohka S, Matsuda N, Tohyama K, et al. (2004). «Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome.». J. Virol. 78 (13): 7186–98. PMC 421661Acessível livremente. PMID 15194795. doi:10.1128/JVI.78.13.7186-7198.2004 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928Acessível livremente. PMID 15489334. doi:10.1101/gr.2596504 
  • de Wit NJ, Verschuure P, Kappé G, et al. (2005). «Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1.». Eur. J. Cell Biol. 83 (7): 337–45. PMID 15503857. doi:10.1078/0171-9335-00396 
  • Chuang JZ, Yeh TY, Bollati F, et al. (2005). «The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.». Dev. Cell. 9 (1): 75–86. PMC 3857739Acessível livremente. PMID 15992542. doi:10.1016/j.devcel.2005.04.003 
  • Yeh TY, Peretti D, Chuang JZ, et al. (2007). «Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin.». Traffic. 7 (11): 1495–502. PMC 3873093Acessível livremente. PMID 16956385. doi:10.1111/j.1600-0854.2006.00482.x 
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