LST1

LST1
Identificadores
Nomes alternativosLST1, Proteína 1 do transcrito específico de leucócito
IDs externosOMIM: 109170 HomoloGene: 136814 GeneCards: LST1
Padrão de expressão RNA




Mais dados de referência de expressão
Ortólogos
EspécieHumanoRato
Entrez

7940

n/a

Ensembl
ENSG00000230791
ENSG00000226182
ENSG00000231048
ENSG00000204482
ENSG00000206433

ENSG00000223465
ENSG00000234514
ENSG00000235915

n/a

UniProt

O00453

n/a

RefSeq (mRNA)
NM_001166538
NM_007161
NM_205837
NM_205838
NM_205839

NM_205840

n/a

RefSeq (proteína)
NP_001160010
NP_009092
NP_995309
NP_995310
NP_995311

NP_995312

n/a

Localização (UCSC)n/an/a
Pesquisa PubMed[1]n/a
Wikidata
Ver/Editar Humano

A Proteína 1 do transcrito específico de leucócito é uma proteína que em humanos é codificada pelo gene LST1.[2][3][4]

Referências

  1. ↑ «Human PubMed Reference:» 
  2. ↑ Nalabolu SR, Shukla H, Nallur G, Parimoo S, Weissman SM (março de 1997). «Genes in a 220-kb region spanning the TNF cluster in human MHC». Genomics. 31 (2): 215–22. PMID 8824804. doi:10.1006/geno.1996.0034 
  3. ↑ de Baey A, Fellerhoff B, Maier S, Martinozzi S, Weidle U, Weiss EH (janeiro de 1998). «Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing». Genomics. 45 (3): 591–600. PMID 9367684. doi:10.1006/geno.1997.4963 
  4. ↑ «Entrez Gene: LST1 leukocyte specific transcript 1» 

Leitura adicional

  • Abraham LJ, Grimsley G, Zhang WJ, et al. (1992). «Polymorphism in the human B144 gene in different MHC haplotypes.». Eur. J. Immunogenet. 19 (3): 165–8. PMID 1352700. doi:10.1111/j.1744-313X.1992.tb00055.x 
  • Holzinger I, de Baey A, Messer G, et al. (1995). «Cloning and genomic characterization of LST1: a new gene in the human TNF region.». Immunogenetics. 42 (5): 315–22. PMID 7590964. doi:10.1007/BF00179392 
  • Pende D, Parolini S, Pessino A, et al. (1999). «Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells». J. Exp. Med. 190 (10): 1505–16. PMC 2195691Acessível livremente. PMID 10562324. doi:10.1084/jem.190.10.1505 
  • Neville MJ, Campbell RD (2000). «Alternative splicing of the LST-1 gene located in the Major Histocompatibility Complex on human chromosome 6». DNA Seq. 8 (3): 155–60. PMID 10668961. doi:10.3109/10425179709034067 
  • Rollinger-Holzinger I, Eibl B, Pauly M, et al. (2000). «LST1: a gene with extensive alternative splicing and immunomodulatory function». J. Immunol. 164 (6): 3169–76. PMID 10706707. doi:10.4049/jimmunol.164.6.3169 
  • Yu X, Weissman SM (2000). «Characterization of the promoter of human leukocyte-specific transcript 1. A small gene with a complex pattern of alternative transcripts». J. Biol. Chem. 275 (44): 34597–608. PMID 10944527. doi:10.1074/jbc.M004700200 
  • Raghunathan A, Sivakamasundari R, Wolenski J, et al. (2001). «Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells». Exp. Cell Res. 268 (2): 230–44. PMID 11478849. doi:10.1006/excr.2001.5290 
  • Ferlazzo G, Tsang ML, Moretta L, et al. (2002). «Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells». J. Exp. Med. 195 (3): 343–51. PMC 2193591Acessível livremente. PMID 11828009. doi:10.1084/jem.20011149 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241Acessível livremente. PMID 12477932. doi:10.1073/pnas.242603899 
  • Castriconi R, Cantoni C, Della Chiesa M, et al. (2003). «Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells». Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4120–5. PMC 153058Acessível livremente. PMID 12646700. doi:10.1073/pnas.0730640100 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6». Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055 
  • Xie T, Rowen L, Aguado B, et al. (2004). «Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse». Genome Res. 13 (12): 2621–36. PMC 403804Acessível livremente. PMID 14656967. doi:10.1101/gr.1736803 
  • Lehner B, Semple JI, Brown SE, et al. (2004). «Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region». Genomics. 83 (1): 153–67. PMID 14667819. doi:10.1016/S0888-7543(03)00235-0 
  • Harrison RE, Sikorski BA, Jongstra J (2005). «Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton». J. Cell Sci. 117 (Pt 10): 2151–7. PMID 15090600. doi:10.1242/jcs.00955 
  • Marafioti T, Mancini C, Ascani S, et al. (2006). «Leukocyte-specific phosphoprotein-1 and PU.1: two useful markers for distinguishing T-cell-rich B-cell lymphoma from lymphocyte-predominant Hodgkin's disease». Haematologica. 89 (8): 957–64. PMID 15339679 
  • Mulcahy H, O'Rourke KP, Adams C, et al. (2006). «LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection». Immunogenetics. 57 (12): 893–903. PMID 16362817. doi:10.1007/s00251-005-0057-2 
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