CD24

Identificatori

Alias

CD24

Identificări externe

OMIM: 600074 MGI: 88323 GeneCards: CD24

Localizarea genei (om)

Cro.	Cromozomul uman 6^[1]

Bandă	6q21	Start	106,969,831 pb^[1]
Bandă	6q21	Final	106,975,627 pb^[1]

Ontologia genei
Funcția moleculară	• protein tyrosine kinase activator activity • signal transducer activity • GO:0001948, GO:0016582 legare de proteină • protein kinase binding
Componenta celulară	• membrană • membrană celulară • suprafață celulară • anchored component of external side of plasma membrane • membrane raft • anchored component of membrane • structură anatomică intracelulară
Procesul biologic	• răspuns la hipoxie • regulation of MAPK cascade • positive regulation of MAP kinase activity • regulation of cytokine-mediated signaling pathway • positive regulation of cytosolic calcium ion concentration • chemokine receptor transport out of membrane raft • T cell costimulation • regulation of phosphorylation • Wnt signaling pathway • negative regulation of transforming growth factor beta3 production • cell activation • immune response-regulating cell surface receptor signaling pathway • răsouns la estrogen • respiratory burst • intrinsic apoptotic signaling pathway • glomerular parietal epithelial cell differentiation • adeziune celulară • glomerular visceral epithelial cell differentiation • cholesterol homeostasis • regulation of epithelial cell differentiation • response to molecule of bacterial origin • cell migration • B cell receptor transport into membrane raft • positive regulation of nephron tubule epithelial cell differentiation • positive regulation of activated T cell proliferation • positive regulation of protein tyrosine kinase activity • adeziune celulă-celulă
Surse: Amigo / QuickGO

Ortologi

Specie

Șoarece

Entrez


100133941


12484

Ensembl


ENSG00000272398


ENSMUSG00000047139

UniProt


P25063


P24807

RefSeq (mRNA)


NM_001291737 NM_001291738 NM_001291739 NM_013230 NM_001359084


NM_009846

RefSeq (proteine)


NP_001278666 NP_001278667 NP_001278668 NP_037362 NP_001346013


NP_033976

Localizare (UCSC)

Chr 6: 106.97 – 106.98 Mb

n/a

Căutare PubMed

^[2]

^[3]

Wikidata

Vedeți/Editați Om

Vedeți/Editați Șoarece

Signal transducer CD24, cunoscută și sub denumirea de cluster of differentiation 24 sau heat stable antigen (HSA), este o proteină care la om este codificată de gena CD24.^[4] CD24 este o moleculă de adeziune celulară.

Funcție

CD24 este o sialoglicoproteină exprimată la suprafața majorității limfocitelor B și neuroblastelor. De asemenea, este exprimată pe neutrofile^[5] și precursori ai acestora începând cu stadiul mielocitelor. Proteina codificată este ancorată printr-o legătură glicozil fosfatidilinozitol (GPI) de suprafața celulei. Proteina contribuie, în plus, la o gamă largă de rețele de semnalizare în aval și este crucială pentru dezvoltarea neuronală.^[6] Legarea încrucișată a CD24 pe suprafața neutrofilelor induce apoptoza^[7] și aceasta pare să fie defectă în sepsis.^[7] Gena CD24 este întâlnită pe cromozomul 6 (6q21). O aliniere a secvenței acestei gene găsește locații genomice similare pe cromozomii 1p36, 3p26, 15q21.3, 20q11.2 și Yq11.222.

Note

^ ^a ^b ^c GRCh38: Ensembl ediția 89: ENSG00000272398 - Ensembl, mai 2017
^ „Referința PubMed pentru om:”.
^ „Referința PubMed pentru șoarece:”.
^ „Mapping of CD24 and homologous sequences to multiple chromosomal loci”. Genomics. 22 (1): 154–61. iulie 1994. doi:10.1006/geno.1994.1356. PMID 7959762.
^ „Assessment of CD24 expression on bone marrow neutrophilic granulocytes: CD24 is a marker for the myelocytic stage of development”. American Journal of Hematology. 71 (4): 348–9. decembrie 2002. doi:10.1002/ajh.10176. PMID 12447971.
^ „The CD24 surface antigen in neural development and disease”. Neurobiology of Disease. 99: 133–144. martie 2017. doi:10.1016/j.nbd.2016.12.011. PMID 27993646.
^ ^a ^b „CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis”. Journal of Immunology. 192 (5): 2449–59. martie 2014. doi:10.4049/jimmunol.1301055. PMID 24501201.

Commons

Wikimedia Commons conține materiale multimedia legate de CD24

Bibliografie

Li D, Zheng L, Jin L, Zhou Y, Li H, Fu J, Shi M, Du P, Wang L, Wu H, Chen GY, Zheng P, Liu Y, Wang FS, Wang S (septembrie 2009). „CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection”. Hepatology. 50 (3): 735–42. doi:10.1002/hep.23047. PMID 19610054.
Piotrowski P, Lianeri M, Wudarski M, Łacki JK, Jagodziński PP (iunie 2010). „CD24 Ala57Val gene polymorphism and the risk of systemic lupus erythematosus”. Tissue Antigens. 75 (6): 696–700. doi:10.1111/j.1399-0039.2010.01447.x. PMID 20230526.
Honeth G, Bendahl PO, Ringnér M, Saal LH, Gruvberger-Saal SK, Lövgren K, Grabau D, Fernö M, Borg A, Hegardt C (2008). „The CD44+/CD24- phenotype is enriched in basal-like breast tumors”. Breast Cancer Research. 10 (3): R53. doi:10.1186/bcr2108. PMC 2481503 . PMID 18559090.
Nagy B, Szendroi A, Romics I (iunie 2009). „Overexpression of CD24, c-myc and phospholipase 2A in prostate cancer tissue samples obtained by needle biopsy”. Pathology Oncology Research. 15 (2): 279–83. doi:10.1007/s12253-008-9077-1. PMID 18752058.
Kim KH, Choi JS, Kim JM, Choi YL, Shin YK, Lee HC, Seong IO, Kim BK, Chae SW, Kim SH (martie 2009). „Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium”. Histology and Histopathology. 24 (3): 309–16. doi:10.14670/HH-24.309. PMID 19130400.
Buess M, Rajski M, Vogel-Durrer BM, Herrmann R, Rochlitz C (octombrie 2009). „Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer”. Neoplasia. 11 (10): 987–1002. doi:10.1593/neo.09670. PMC 2745665 . PMID 19794958.
Pruszak J, Ludwig W, Blak A, Alavian K, Isacson O (decembrie 2009). „CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells”. Stem Cells. 27 (12): 2928–40. doi:10.1002/stem.211. PMC 3322476 . PMID 19725119.
Liu Y, Chen GY, Zheng P (decembrie 2009). „CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns”. Trends in Immunology. 30 (12): 557–61. doi:10.1016/j.it.2009.09.006. PMC 2788100 . PMID 19786366.
Vesuna F, Lisok A, Kimble B, Raman V (decembrie 2009). „Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression”. Neoplasia. 11 (12): 1318–28. doi:10.1593/neo.91084. PMC 2794513 . PMID 20019840.
Sagiv E, Arber N (februarie 2008). „The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy”. Expert Review of Gastroenterology & Hepatology^⁠(d). 2 (1): 125–33. doi:10.1586/17474124.2.1.125. PMID 19072375.
Bauerschmitz GJ, Ranki T, Kangasniemi L, Ribacka C, Eriksson M, Porten M, Herrmann I, Ristimäki A, Virkkunen P, Tarkkanen M, Hakkarainen T, Kanerva A, Rein D, Pesonen S, Hemminki A (iulie 2008). „Tissue-specific promoters active in CD44+CD24-/low breast cancer cells”. Cancer Research. 68 (14): 5533–9. doi:10.1158/0008-5472.CAN-07-5288. PMID 18632604.
Carl JW, Liu JQ, Joshi PS, El-Omrani HY, Yin L, Zheng X, Whitacre CC, Liu Y, Bai XF (iulie 2008). „Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway”. Journal of Immunology. 181 (1): 320–8. doi:10.4049/jimmunol.181.1.320. PMID 18566397.
Baumhoer D, Riener MO, Zlobec I, Tornillo L, Vogetseder A, Kristiansen G, Dietmaier W, Hartmann A, Wuensch PH, Sessa F, Ruemmele P, Terracciano LM (februarie 2009). „Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater”. Modern Pathology. 22 (2): 306–13. doi:10.1038/modpathol.2008.192. PMID 19043399.
Wang W, Wang X, Peng L, Deng Q, Liang Y, Qing H, Jiang B (ianuarie 2010). „CD24-dependent MAPK pathway activation is required for colorectal cancer cell proliferation”. Cancer Science. 101 (1): 112–9. doi:10.1111/j.1349-7006.2009.01370.x. PMID 19860845.
Sano A, Kato H, Sakurai S, Sakai M, Tanaka N, Inose T, Saito K, Sohda M, Nakajima M, Nakajima T, Kuwano H (februarie 2009). „CD24 expression is a novel prognostic factor in esophageal squamous cell carcinoma”. Annals of Surgical Oncology. 16 (2): 506–14. doi:10.1245/s10434-008-0252-0. PMID 19050962.
Yang XR, Xu Y, Yu B, Zhou J, Li JC, Qiu SJ, Shi YH, Wang XY, Dai Z, Shi GM, Wu B, Wu LM, Yang GH, Zhang BH, Qin WX, Fan J (septembrie 2009). „CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery”. Clinical Cancer Research. 15 (17): 5518–27. doi:10.1158/1078-0432.CCR-09-0151. PMID 19706825.
Lee JH, Kim SH, Lee ES, Kim YS (noiembrie 2009). „CD24 overexpression in cancer development and progression: a meta-analysis”. Oncology Reports. 22 (5): 1149–56. doi:10.3892/or_00000548. PMID 19787233.
Gekara NO, Weiss S (noiembrie 2004). „Lipid rafts clustering and signalling by listeriolysin O”. Biochemical Society Transactions. 32 (Pt 5): 712–4. doi:10.1042/BST0320712. PMID 15493995.
Athanassiadou P, Grapsa D, Gonidi M, Athanassiadou AM, Tsipis A, Patsouris E (2009). „CD24 expression has a prognostic impact in breast carcinoma”. Pathology, Research and Practice. 205 (8): 524–33. doi:10.1016/j.prp.2009.01.008. PMID 19243896.
Ronaghi M, Vallian S, Etemadifar M (decembrie 2009). „CD24 gene polymorphism is associated with the disease progression and susceptibility to multiple sclerosis in the Iranian population”. Psychiatry Research. 170 (2–3): 271–2. doi:10.1016/j.psychres.2009.01.002. PMID 19896210.
van de Peppel J, Schaaf G, Matos A, Guo Y, Strini T, Verschoor W, Dudakovic A, van Wijnen A, van Leeuwen J (martie 2021). „Cell Surface Glycoprotein CD24 Marks Bone Marrow-Derived Human Mesenchymal Stem/Stromal Cells with Reduced Proliferative and Differentiation Capacity In Vitro”. Stem Cells & Development: 325–336. doi:10.1089/scd.2021.0027. PMID 33593128.