Estazolam
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(IUPAC) ime | |||
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8-hloro-6-fenil- 4H-1,2,4-triazolo(4,3-a)- 1,4-benzodiazepin | |||
Klinički podaci | |||
AHFS/Drugs.com | Monografija | ||
MedlinePlus | a691003 | ||
Identifikatori | |||
CAS broj | 29975-16-4 | ||
ATC kod | N05CD04 | ||
PubChem[1][2] | 3261 | ||
DrugBank | DB01215 | ||
ChemSpider[3] | 3146 | ||
UNII | 36S3EQV54C ![]() | ||
KEGG[4] | D00311 ![]() | ||
ChEBI | CHEBI:4858 ![]() | ||
ChEMBL[5] | CHEMBL285674 ![]() | ||
Hemijski podaci | |||
Formula | C16H11ClN4 | ||
Mol. masa | 294,7 | ||
SMILES | eMolekuli & PubHem | ||
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Farmakokinetički podaci | |||
Bioraspoloživost | 93% | ||
Metabolizam | Hepatički | ||
Poluvreme eliminacije | 10-24 sata | ||
Izlučivanje | Renalno | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | Schedule IV (SAD) | ||
Način primene | Oralno |
Estazolam[6] (ProSom, Eurodin) je benzodiazepinski derivat. Ovaj lek je razvilo preduzeće Upjohn tokom 1970-tih.[7] On poseduje anksiolitička, antikonvulsivna, sedativna i miorelaksantna svojstva. Estazolam je benzodiazepin srednje dužine dejstva.[8][9][10][11]
On se često propisuje za kratkotrajne tretmane insomnije.
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ US Patent 4116956
- ↑ US Patent 3701782 - 1-CARBOLOWER ALKOXY-6-PHENYL-4H-S-TRIAZOLO(1,4)BENZODIAZEPINE COMPOUNDS
- ↑ Watanabe S, Ohta H, Sakurai Y, Takao K, Ueki S: [Electroencephalographic effects of 450191-S and its metabolites in rabbits with chronic electrode implants] Nippon Yakurigaku Zasshi. 1986 Jul;88(1):19-32. PMID 3758874
- ↑ Oishi R, Nishibori M, Itoh Y, Saeki K: Diazepam-induced decrease in histamine turnover in mouse brain. Eur J Pharmacol. 1986 May 27;124(3):337-42. PMID 3089825
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.
Povezano
Spoljašnje veze
![]() | Portal Medicina |
![]() | Portal Hemija |
- Rx-List - Estazolam Arhivirano 2006-02-03 na Wayback Machine-u
- Inchem - Estazolam
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Dialkil-fenoli | |||||||||
CL-218,872 • Eszopiklon • Indiplon • Nekopidem • Pazinaklon • ROD-188 • Saripidem • Suproklon • Suriklon • SX-3228 • U-89843A • U-90042 • Zaleplon • Zolpidem • Zopiklon | |||||||||
Neuroaktivni steroidi |
receptor
Acetilholinski receptor
α1- adrenergički
Selektivni 5-HT2A & α1-adrenergički antagonisti |
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GHB receptor
GHB Tip |
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Oreksinski antagonisti |
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negrupisani
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