Orotat fosforiboziltransferaza
| Orotat fosforiboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.4.2.10 | ||||||||
| CAS broj | 9030-25-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Orotat fosforiboziltransferaza (EC 2.4.2.10, orotidilna kiselina fosforilaza, orotidin-5'-fosfat pirofosforilaza, OPRTaze, orotat fosforibozil pirofosfat transferaza, orotinsko kiselinska fosforiboziltransferaza, orotidin 5'-monofosfatna pirofosforilaza, orotidin monofosfatna pirofosforilaza, orotidinska fosforiboziltransferaza, orotidilatna fosforiboziltransferaza, orotidilatna pirofosforilaza, orotidilno kiselinska pirofosforilaza, orotidilna fosforilaza, orotidilna pirofosforilaza) je enzim sa sistematskim imenom orotidin-5'-fosfat:difosfat fosfo-alfa-D-ribozil-transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- orotidin 5'-fosfat + difosfat orotat + 5-fosfo-alfa-D-riboza 1-difosfat
Enzim iz viših eukariota takođe katalizuje reakcije enzima EC 4.1.1.23, orotidin-5'-fosfat dekarboksilaza.
Reference
- ↑ Jones, M.E., Kavipurapu, P.R. and Traut, T.W. (1978). „Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)”. Methods Enzymol. 51: 155-167. PMID 692383.
- ↑ Lieberman, I., Kornberg, A. and Simms, E.S. (1955). „Enzymatic synthesis of pyrimidine nucleotides. Orotidine-5′-phosphate and uridine-5′-phosphate”. J. Biol. Chem. 215: 403-415. PMID 14392174.
- ↑ McClard, R.W., Black, M.J., Livingstone, L.R. and Jones, M.E. (1980). „Isolation and initial characterization of the single polypeptide that synthesizes uridine 5′-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5′-monophosphate synthase”. Biochemistry 19: 4699-4706. PMID 6893554.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Orotate+phosphoribosyltransferase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
