Sulfatid
Sulfatid | |||
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Identifikacija | |||
PubChem[1][2] | 5459389 | ||
DrugBank | DB04780 | ||
Jmol-3D slike | Slika 1 | ||
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Svojstva | |||
Molekulska formula | C48H93NO12S | ||
Molarna masa | 908.32 g mol−1 | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
Sulfatidi su klasa sulfatisanih galaktozilceramida koji se prvenstveno sintetišu u oligodendrocitima u centralnom nervnom sistemu. Sulfatidi su tip sulfolipida.[3][4]
Klinički značaj
Alteracije sulfatidnog metabolizma, razmena i homeostaza su prisutni u najranijim klinički prepoznatljivim stepenima Alchajmerove bolesti i vezani su za metahromatsku leukodistrofiju (MLD).
Osobine
Osobina | Vrednost |
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Broj akceptora vodonika | 12 |
Broj donora vodonika | 7 |
Broj rotacionih veza | 43 |
Particioni koeficijent[5] (ALogP) | 12,3 |
Rastvorljivost[6] (logS, log(mol/L)) | -17,2 |
Polarna površina[7] (PSA, Å2) | 220,7 |
Povezano
- Sulfatidoza
Literatura
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Michael A Lieberman, Rick Ricer (2010). Lippincott's Illustrated Q&A Review of Biochemistry (1 Pap/Psc ed izd.). Lippincott Williams & Wilkins. ISBN 1605473022.
- ↑ Huang JQ, Trasler JM, Igdoura S, Michaud J, Hanal N, Gravel RA (October 1997). „Apoptotic cell death in mouse models of GM2 gangliosidosis and observations on human Tay-Sachs and Sandhoff diseases”. Human molecular genetics 6 (11): 1879–85. DOI:10.1093/hmg/6.11.1879. PMID 9302266.
- ↑ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o.
- ↑ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.
- ↑ Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.
Spoljašnje veze
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- MeSH Sulfatides
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put
GM1 • GM2 • GD2 • GM3 | |
sulfatid | |
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