Transferinski receptor
Transferinski receptor (p90, CD71) | |
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Dimer transferinskog receptora 1 (čovjek) | |
Identifikatori | |
Simbol | TFRC |
Alt. simboli | CD71, TFR1 |
Entrez | 7037 |
HUGO | 11763 |
OMIM | 190010 |
RefSeq | NM_003234 |
UniProt | P02786 |
Drugi podaci | |
Lokus | Hromozom 3 q29 |
Transferinski receptor 2 | |
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Identifikatori | |
Simbol | TFR2 |
Alt. simboli | HFE3, TFRC2 |
Entrez | 7036 |
Hugo | 11762 |
OMIM | 604720 |
RefSek | NM_003227 |
UniProt | Q9UP52 |
Drugi podaci | |
Lokus | Hrom. 7 q22 |
Transferinski receptor (TfR) je prenosni protein za transferin. On je potreban za unos gvožđa u ćeliju i kontrolisan je intraćelijskom koncentracijom gvožđa. On unosi gvožđe internalizacijom kompleksa transferin-gvožđe putem endocitoze posredovane receptorom.[1]
Regulacija
Niske koncentracije gvožđa podstiču povećanje nivoa transferinskog receptora, da bi se povećao unos gvožđa u ćeliju. Transferinski receptor učestvuje u održavanju ćelijske homeostaze gvožđa.
TfR produkcija u ćeliji je regulisana nivoima gvožđa posredstvom IRE-BP proteina (respons na gvožđe/regulatorni element vezivanja proteina), koji se naziva i regulatorni protein gvožđa (engl. Iron Regulatory Protein - IRP). Taj protein se vezuje za strukturu sličnu ukosnici na 3' UTR TfR receptora. Nakon vezivanja dolazi do inhibicije degradacije iRNK za IRE.
Reference
- ↑ Qian ZM, Li H, Sun H, Ho K (December 2002). „Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway”. Pharmacol. Rev. 54 (4): 561–87. DOI:10.1124/pr.54.4.561. PMID 12429868. ; Figure 3: The cycle of transferrin and transferrin receptor 1-mediated cellular iron uptake.[mrtav link]
Literatura
- Testa U, Kühn L, Petrini M, Quaranta MT, Pelosi E, Peschle C (July 1991). „Differential regulation of iron regulatory element-binding protein(s) in cell extracts of activated lymphocytes versus monocytes-macrophages”. J. Biol. Chem. 266 (21): 13925–30. PMID 1856222.
- Daniels TR, Delgado T, Rodriguez JA, Helguera G, Penichet ML (November 2006). „The transferrin receptor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer”. Clin. Immunol. 121 (2): 144–58. DOI:10.1016/j.clim.2006.06.010. PMID 16904380. ; Figure 3: Cellular uptake of iron through the Tf system via receptor-mediated endocytosis. Arhivirano 2015-09-24 na Wayback Machine-u
- Daniels TR, Delgado T, Helguera G, Penichet ML (November 2006). „The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells”. Clin. Immunol. 121 (2): 159–76. DOI:10.1016/j.clim.2006.06.006. PMID 16920030.
Povezano
Spoljašnje veze
- MeSH Transferrin+receptor
- Okam M (29. 01. 2001.). „Transerrin and Iron Transport Physiology”. Information Center for Sickle Cell and Thalassemic Disorders. Brigham and Women's Hospital and Harvard Medical School. Pristupljeno 19. 12. 2010.
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