Aminokaproinska kiselina : Osobine, Reference, Literatura, Spoljašnje veze Википедија

Aminokaproinska kiselina

Aminokaproinska kiselina
Klinički podaci


Prodajno ime	Acepramin, Acepramine, Afibrin, Amicar
Drugs.com	acid.html Monografija
Način primene	Intravenozno, oralno
Farmakokinetički podaci
Poluvreme eliminacije	2 h
Izlučivanje	Renalno

Identifikatori
CAS broj	60-32-2^Y
ATC kod	B02AA01 (WHO)
PubChem	CID 564
DrugBank	DB00513^Y
ChemSpider	548^Y
KEGG	C02378^Y
ChEBI	CHEBI:16586^Y
ChEMBL	CHEMBL1046^Y
Hemijski podaci
Formula	C₆H₁₃NO₂
Molarna masa	131,173
SMILES NCCCCCC(O)=O
InChI InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)^Y Key:SLXKOJJOQWFEFD-UHFFFAOYSA-N^Y

Fizički podaci
Tačka topljenja	205 °C (401 °F)

Aminokaproinska kiselina je organsko jedinjenje, koje sadrži 6 atoma ugljenika i ima molekulsku masu od 131,173 Da.^[1]^[2]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	2
Broj rotacionih veza	5
Particioni koeficijent^[3] (ALogP)	-2,2
Rastvorljivost^[4] (logS, log(mol/L))	-1,0
Polarna površina^[5] (PSA, Å²)	63,3

^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.