Bcl-2
B-ćelijski CLL/limfom 2 | |||||||||||
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![]() PDB prikaz bazairan na 1GJH, 1G5M. | |||||||||||
Dostupne strukture | |||||||||||
1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0 | |||||||||||
Identifikatori | |||||||||||
Simboli | BCL2; Bcl-2; PPP1R50 | ||||||||||
Vanjski ID | OMIM: 151430 MGI: 88138 HomoloGene: 527 GeneCards: BCL2 Gene | ||||||||||
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Pregled RNK izražavanja | |||||||||||
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podaci | |||||||||||
Ortolozi | |||||||||||
Vrsta | Čovek | Miš | |||||||||
Entrez | 596 | 12043 | |||||||||
Ensembl | ENSG00000171791 | ENSMUSG00000057329 | |||||||||
UniProt | P10415 | Q4VBF6 | |||||||||
RefSeq (mRNA) | NM_000633.2 | NM_009741.3 | |||||||||
RefSeq (protein) | NP_000624.2 | NP_033871.2 | |||||||||
Lokacija (UCSC) | Chr 18: 60.79 - 60.99 Mb | Chr 1: 108.43 - 108.61 Mb | |||||||||
PubMed pretraga | [1] | [2] |
Bcl-2 (B-ćelijski limfom 2) je član Bcl-2 familije proteinskih regulatora apoptoze. On je kodiran BCL2 genom.[1][2] Bcl-2 je drugi član niza proteina koji su inicijalno bili opisani u kontekstu hromozomske translokacije hromozoma 14 i 18 kod folikularnih limfoma. Bcl-2 ortolozi[3] postoje kod mnogobrojnih sisara. Dve izoforme Bcl-2, Izoforma 1, takođe poznata kao 1G5M, i Izoforma 2, poznata kao 1G5O/1GJH, imaju sličnu prostornu strukturu. Međutim, one se razlikuju u njihovoj sposobnosti vezivanja BAD u BAK proteina, kao i po strukturnoj topologiji i elektrostatičkom potencijalu vezujućeg žljeba. Iz toga sledi da Bcl-2 izoforme imaju različite antiapoptotičke aktivnosti.[4]
Interakcije
Bcl-2 formira interakcije sa RAD9A,[5] BAK1,[6][7] Retikulon 4,[8] Bcl-2 asocirani X protein,[5][6][9][10] Kaspaza 8,[11][12] BECN1,[13] SOD1,[14] Bcl-2 interagujući ubica,[15][16] BH3 interagujući domen agonista umiranja,[15][17] RRAS,[18] C-Raf,[19] BCL2L11,[15][20][21] BNIPL,[22][23] HRK,[15][24] PSEN1,[25] BMF,[26] BNIP2,[22][27] BNIP3,[27][28] Faktor rasta nerva IB,[6] BCL2-sličan 1,[6][29] Myc,[30] BCAP31,[31] SMN1,[32] CAPN2,[33] PPP2CA,[34] Noxa,[15][35] Cdk1,[36][37] TP53BP2,[38] Bcl-2 vezan promoter smrti[15][39] i IRS1.[40]
Ljudski BCL-2 geni
BAK, BAK1, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L13, BCL2L14, BCL2L2,BCL2L7P1, BOK, MCL1, LGALS7 (Galektin-7)
Reference
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Vidi još
- Apoptoza
- Apoptozom
- Kaspaza
- Citohrom c
- Noxa
- Mitohondrija
Spoljašnje veze
- Baza podataka Bcl-2 familije
- bcl-2+Genes на US National Library of Medicine Medical Subject Headings (MeSH)
- c-bcl-2+Proteins на US National Library of Medicine Medical Subject Headings (MeSH)
- п
- р
- у
Membrana | Fas ligand • Fas receptor |
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Intracelularno | Smrt-indukujući signalni kompleks DAXX • ASK1 FADD • Kaspaza 8 • BID Citohrom c • Kaspaza 9 • Kaspaza 3 pro-apoptotični: BAX • BAK1/Bcl-2 homologni antagonist ubica • Bcl-2-asocirani smrt promoter anti-apoptotični: Bcl-2 • Bcl-xL |
Membrana | Faktori nekroze tumora • Receptor faktora nekroze tumora |
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Intracelularno |
IAP | |
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Apoptoza-indukujući faktor |
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