CLIC6

Hloridni intracelularni kanal 6

Identifikatori

CLIC6; CLIC1L

Vanjski ID

MGI: 2146607 HomoloGene: 43154 GeneCards: CLIC6 Gene

Ontologija gena
Molekularna funkcija	• aktivnost naponom kontrolisanog jonskog kanala • aktivnost naponom kontrolisanog hloridnog kanala
Celularna komponenta	• cytoplasm • ćelijska membrana • integralno sa membranom • kompleks hloridnog kanala
Biološki proces	• jonski transport

Ortolozi

Vrsta

Čovek

Miš

Entrez

54102

209195

Ensembl

ENSG00000159212

ENSMUSG00000022949

UniProt

Q96NY7

Q8BHB9

RefSeq (mRNA)

NM_053277.1

NM_172469.3

RefSeq (protein)

NP_444507.1

NP_766057.1

Lokacija (UCSC)

Chr 21:
36.04 - 36.09 Mb

Chr 16:
92.49 - 92.54 Mb

PubMed pretraga

[1]

[2]

Hloridni intracelularni kanal, protein 6 je protein koji je kod ljudi kodiran CLIC6 genom.^[1]^[2] Ovaj gen je deo velikog trostrukog regiona nađenog na hromozomima 1, 6, i 21. Alternativno splajsovane transkriptne varijante su poznate, ali njihov biološki značaj nije poznat.^[2]

Interakcije

CLIC6 formira interakcije sa dopaminskim receptorom D3.^[3]

Reference

^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (2000). „The DNA sequence of human chromosome 21”. Nature. 405 (6784): 311—9. PMID 10830953. doi:10.1038/35012518.
^ ^а ^б „Entrez Gene: CLIC6 chloride intracellular channel 6”.
^ Griffon, Nathalie; Jeanneteau Freddy (2003). „CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors”. Brain Res. Mol. Brain Res. Netherlands. 117 (1): 47—57. ISSN 0169-328X. PMID 14499480. doi:10.1016/S0169-328X(03)00283-3.

Literatura

Singh H (2010). „Two decades with dimorphic Chloride Intracellular Channels (CLICs)”. Febs letters. 584 (10): 2112—21. PMID 20226783. doi:10.1016/j.febslet.2010.03.013.
Hillier LD; Lennon G; Becker M (1997). „Generation and analysis of 280,000 human expressed sequence tags”. Genome Res. 6 (9): 807—28. PMID 8889549. doi:10.1101/gr.6.9.807.
Strippoli P; D'Addabbo P; Lenzi L (2003). „Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q”. Mamm. Genome. 13 (8): 456—62. PMID 12226712. doi:10.1007/s00335-001-2157-0.
Strausberg RL; Feingold EA; Grouse LH (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Scanlan MJ; Gout I; Gordon CM (2003). „Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression”. Cancer Immun. 1: 4. PMID 12747765.
Griffon N; Jeanneteau F; Prieur F (2003). „CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors”. Brain Res. Mol. Brain Res. 117 (1): 47—57. PMID 14499480. doi:10.1016/S0169-328X(03)00283-3.
Friedli M; Guipponi M; Bertrand S (2004). „Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12”. Gene. 320: 31—40. PMID 14597386. doi:10.1016/S0378-1119(03)00830-8.
Ota T; Suzuki Y; Nishikawa T (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS; Wagner L; Feingold EA (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.

Vidi još

Hloridni kanal

Spoljašnje veze

CLIC6+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)

Membranski transportni proteini: Jonski kanali (TC 1A)

Ca²⁺: Kalcijumski kanali

Naponom-kontrolisani	L-tip/Ca_vα (1.1, 1.2, 1.3, 1.4) · N-tip/Ca_vα2.2 · P-tip/Ca_vα(2.1) · Q-tip/Ca_vα2.1 · R-tip/Ca_vα2.3 · T-tip/Ca_vα(3.1, 3.2, 3.3) α₂δ-podjedinica (1, 2) · β-podjedinica (β1, β2, β3, β4) · γ-podjedinica (γ1, γ2, γ3, γ4) Katjonski kanali sperme (1, 2, 3, 4) · Dvoporni kanal (1, 2)
Ligandom kontrolisani	Inozitol trisfosfatni receptor (1, 2, 3) · Rianodinski receptor (1, 2, 3)

Na⁺: Natrijumovi kanali

Naponom-kontrolisani	Na_vα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 7A) · Na_vβ (1, 2, 3, 4)
Konstitutivno aktivni	Epitelni natrijumski kanal (α, β, γ, δ)

K⁺: Kalijumovi kanali

Naponom-kontrolisani	K_vα1-6 (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8) · (2.1, 2.2) · (3.1, 3.2, 3.3, 3.4) · (4.1, 4.2, 4.3) · (5.1) · (6.1, 6.2, 6.3, 6.4) K_vα7-12 (7.1, 7.2, 7.3, 7.4, 7.5) · (8.1, 8.2) · (9.1, 9.2, 9.3) · (10.1, 10.2) · (11.1/hERG, 11.2, 11.3) · (12.1, 12.2, 12.3) K_vβ (1, 2, 3) · KCNIP (1, 2, 3, 4) · minK/ISK · minK/ISK-sličan · MiRP (1, 2, 3) · Shaker gen
Kalcijumom-aktivirani	BK kanal (α1, β1, β2, β3, β4) · SK kanal (SK1, SK2, SK3, SK4) · K_Ca (1.1, 2.1, 2.2, 2.3, 3.1, 4.1, 4.2, 5.1)
Unutrašnji-ispravljači	K_ATP · K_ir (1.1, 2.1, 2.2, 2.3, 2.4, 2.6) · GIRK/K_ir (3.1, 3.2, 3.3, 3.4) · K_ir (4.1, 4.2, 5.1, 6.1, 6.2, 7.1)
Domen tandema pora	K2P (1, 2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, 16, 17, 18)

Drugi

M⁺: TRP katjonski kanal	TRPA (1) · TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) · TRPM (1, 2, 3, 4, 5, 6, 7, 8) · TRPML (1, 2, 3) · TRPP (1, 2) · TRPV (1, 2, 3, 4, 5, 6)
Cl^-: Hloridni kanal	ANO1 · Bestrofin (1, 2) · CFTR · CLCA (1, 2, 3, 4) · CLCN (1, 2, 3, 4, 5, 6, 7, KA, KB) · CLIC (1, 2, 3, 4, 5, 6, L1) · CLNS (1A, 1B)
Cikličnim nukleotidom-kontrolisani (FC)	α (1, 2, 3, 4) · β (1, 2, 3) · HCN (1, 2, 3, 4)
Porin	Akvaporin (1, 2, 3, 4, 5, 7, 8, 9) · Anjonski kanali zavisni od napona (1, 2, 3) · Generalna bakterijska porinska familija
Propusna veza	Koneksin: A (GJA1, GJA3, GJA4, GJA5, GJA8, GJA9, GJA10) · B (GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7) · C (GJC1, GJC2, GJC3) · D (GJD2, GJD3, GJD4) · E (GJE1) Ineksin
Generalno	Ligandom-kontrolisani jonski kanal · Naponom-kontrolisani jonski kanal · Rastezanjem-aktivirani jonski kanal