Cefpiramid
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Klinički podaci | |
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Prodajno ime | Cefpiramide [USAN:INN], Cefpiramide Sodium, Cefpiramido [INN-Spanish], Cefpiramidum [INN-Latin] |
Drugs.com | Monografija |
Farmakokinetički podaci | |
Poluvreme eliminacije | 4,44 h |
Identifikatori | |
CAS broj | 70797-11-4 ![]() |
ATC kod | J01DD11 (WHO) |
PubChem | CID 636405 |
DrugBank | DB00430 ![]() |
ChemSpider | 552192 ![]() |
KEGG | C13376 ![]() |
ChEBI | CHEBI:59213 ![]() |
ChEMBL | CHEMBL1201204 ![]() |
Hemijski podaci | |
Formula | C25H24N8O7S2 |
Molarna masa | 612,637 |
SMILES
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InChI
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Cefpiramid je organsko jedinjenje, koje sadrži 25 atoma ugljenika i ima molekulsku masu od 612,637 Da.[1][2][3][4][5]
Osobine
Osobina | Vrednost |
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Broj akceptora vodonika | 13 |
Broj donora vodonika | 5 |
Broj rotacionih veza | 9 |
Particioni koeficijent[6] (ALogP) | 0,0 |
Rastvorljivost[7] (logS, log(mol/L)) | -5,1 |
Polarna površina[8] (PSA, Å2) | 263,4 |
Reference
- ^ Wang H, Yu Y, Xie X, Wang C, Zhang Y, Yuan Y, Zhang X, Liu J, Wang P, Chen M: In-vitro antibacterial activities of cefpiramide and other broad-spectrum antibiotics against 440 clinical isolates in China. J Infect Chemother. 2000 Jun;6(2):81-5. PMID 11810540
- ^ Iakovlev VP, Vishnevskii VA, Khlebnikov EP, Khadin IM, Plavlova MV, Elagina LV, Izotova GN: [Cefpiramide (Tamicin) in the treatment of purulent complications of abdominal surgery] Antibiot Khimioter. 1995 Sep;40(9):30-4. PMID 8651827
- ^ Sampi K, Hattori M: [Comparative study of cefpiramide + amikacin versus piperacillin + amikacin in granulocytopenic patients: a randomized, prospective study] Gan To Kagaku Ryoho. 1992 Aug;19(9):1315-20. PMID 1503486
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Cefpiramide
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