Piperacilin
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Klinički podaci | |
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Drugs.com | Monografija |
Način primene | Intramaskularno, intravenozno |
Farmakokinetički podaci | |
Poluvreme eliminacije | 36-72 minuta |
Identifikatori | |
CAS broj | 66258-76-2 ![]() |
ATC kod | J01CA12 (WHO) |
PubChem | CID 43672 |
DrugBank | DB00319 ![]() |
ChemSpider | 39798 ![]() |
KEGG | C07361 ![]() |
ChEBI | CHEBI:8232 ![]() |
ChEMBL | CHEMBL702 ![]() |
Hemijski podaci | |
Formula | C23H27N5O7S |
Molarna masa | 517,555 |
SMILES
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InChI
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Piperacilin je organsko jedinjenje, koje sadrži 23 atoma ugljenika i ima molekulsku masu od 517,555 Da.[1][2][3]
Osobine
Osobina | Vrednost |
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Broj akceptora vodonika | 8 |
Broj donora vodonika | 3 |
Broj rotacionih veza | 6 |
Particioni koeficijent[4] (ALogP) | -0,1 |
Rastvorljivost[5] (logS, log(mol/L)) | -4,2 |
Polarna površina[6] (PSA, Å2) | 181,7 |
Reference
- ^ Lau WK, Mercer D, Itani KM, Nicolau DP, Kuti JL, Mansfield D, Dana A: Randomized, open-label, comparative study of piperacillin-tazobactam administered by continuous infusion versus intermittent infusion for treatment of hospitalized patients with complicated intra-abdominal infection. Antimicrob Agents Chemother. 2006 Nov;50(11):3556-61. Epub 2006 Aug 28. PMID 16940077
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126. уреди
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958. уреди
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. уреди
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. уреди
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Piperacillin
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