Teikoplanin
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Klinički podaci | |
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Prodajno ime | Tagocid, Targocid |
Drugs.com | Monografija |
Farmakokinetički podaci | |
Poluvreme eliminacije | 70-100 h |
Identifikatori | |
CAS broj | 61036-62-2 ![]() |
ATC kod | J01XA02 (WHO) |
PubChem | CID 16129712 |
DrugBank | DB06149 ![]() |
ChemSpider | 16736197 ![]() |
UNII | 4U3D3YY81M ![]() |
KEGG | D02142 ![]() |
ChEMBL | CHEMBL415428 ![]() |
NIAID ChemDB | 007693 |
Hemijski podaci | |
Formula | Varijabilna |
Molarna masa | 1564.3 to 1907.7 g/mol |
InChI
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Teikoplanin je antibiotik koji se koristi kao profilaksivno sredstvo i za lečenje ozbiljnih infekcija uzrokovanih Gram-positivnim bakterijama, uključujuči meticilin-rezistentni Staphylococcus aureus i Enterococcus faecalis. On je semisintetički glikopeptidni antibiotik čiji opseg aktivnosti je sličan vankomicinu. Njegov mehanizam dejstva je da inhibira sintezu bakterijskog ćelijskog zida.[1][2][3][4][5][6]
Reference
- ^ de Lalla F, Nicolin R, Rinaldi E, Scarpellini P, Rigoli R, Manfrin V, Tramarin A: Prospective study of oral teicoplanin versus oral vancomycin for therapy of pseudomembranous colitis and Clostridium difficile-associated diarrhea. Antimicrob Agents Chemother. 1992 Oct;36(10):2192-6. PMID 1444298
- ^ Bernareggi A, Borghi A, Borgonovi M, Cavenaghi L, Ferrari P, Vekey K, Zanol M, Zerilli LF: Teicoplanin metabolism in humans. Antimicrob Agents Chemother. 1992 Aug;36(8):1744-9. PMID 1416858
- ^ Yano R, Nakamura T, Tsukamoto H, Igarashi T, Goto N, Wakiya Y, Masada M: Variability in teicoplanin protein binding and its prediction using serum albumin concentrations. Ther Drug Monit. 2007 Aug;29(4):399-403. PMID 17667792
- ^ Pryka RD, Rodvold KA, Rotschafer JC: Teicoplanin: an investigational glycopeptide antibiotic. Clin Pharm. 1988 Sep;7(9):647-58. PMID 2977108
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126. уреди
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958. уреди
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Teicoplanin
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