ARFIP2

Uygun yapılar

Ortolog araması: PDBe RCSB

PDB kimlik kodlarının listesi
1I49, 1I4D, 1I4L, 1I4T, 4DCN

Tanımlayıcılar

Başka adlar

ARFIP2, POR1, ADP ribozillenme faktörü etkileşimli protein 2, ADP ribozilasyon faktörü etkileşimli protein 2

Dış kimlikler

OMIM: 601638 MGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2

Gen yerleşimi (İnsan)

Krom.	11. Kromozom (insan)^[1]

Bant	11p15.4	Başlangıç	6,474,683 bç^[1]
Bant	11p15.4	Bitiş	6,481,479 bç^[1]

RNA ekspresyonu deseni

Daha çok ekspresyon verisi başvurusu

Gen ontolojisi
Moleküler işlevi	• phosphatidylinositol-4-phosphate binding • protein domain specific binding • GO:0001948, GO:0016582 protein bağlanması • GTP binding • identical protein binding • cadherin binding • GTP-dependent protein binding • phospholipid binding
Hücresel bileşeni	• cell cortex • trans-Golgi network membrane • Hücre zarı • ruffle • Sitozol • sitoplazma
Biyolojik süreci	• ruffle organization • small GTPase mediated signal transduction • actin cytoskeleton organization • regulation of Arp2/3 complex-mediated actin nucleation • lamellipodium assembly • intracellular protein transport
Kaynaklar:Amigo / QuickGO

Ortologlar

Türler

İnsan

Fare

Entrez


23647


76932

Ensembl


ENSG00000132254


ENSMUSG00000030881

UniProt


P53365


Q8K221

RefSeq (mRNA)


NM_001242854 NM_001242855 NM_001242856 NM_012402


NM_029802

RefSeq (protein)

NP_001229783 NP_001229784 NP_001229785 NP_036534 NP_001357335
NP_001357337 NP_001357338 NP_001357340 NP_001357341 NP_001357342 NP_001363487 NP_001363488 NP_001363489 NP_001363490 NP_001363491 NP_001363492 NP_001363493


NP_084078

Yerleşim (UCSC)

Krom. 11: 6.47 – 6.48 Mb

n/a

PubMed araması

^[2]

^[3]

Vikiveri

İnsan'ı Gör/Düzenle

Fare'yi Gör/Düzenle

Arfaptin 2, insanlarda ARFIP2 geni tarafından kodlanan bir proteindir.^[4]^[5]^[6]

Etkileşimler

ARFIP2'nin Arf6,^[7]^[8] ARF3,^[5] ARF5 ve RAC1 ile etkileşime girdiği gösterilmiştir.^[4]^[9]

Konuyla ilgili yayınlar

D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L (Eylül 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). ss. 5445-54. doi:10.1093/emboj/16.17.5445. PMC 1170175 $2. PMID 9312003.
Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ (Mayıs 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). ss. 215-9. doi:10.1038/35075620. PMID 11346801.
Shin OH, Exton JH (Ağustos 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). ss. 1267-73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
Peters PJ, Ning K, Palacios F, Boshans RL, Kazantsev A, Thompson LM, Woodman B, Bates GP, D'Souza-Schorey C (Mart 2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein". Nature Cell Biology. 4 (3). ss. 240-5. doi:10.1038/ncb761. PMID 11854752.
Lu L, Hong W (Eylül 2003). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Molecular Biology of the Cell. 14 (9). ss. 3767-81. doi:10.1091/mbc.E03-01-0864. PMC 196566 $2. PMID 12972563.
Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S (Haziran 2005). "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment". The Journal of Biological Chemistry. 280 (23). ss. 22021-8. doi:10.1074/jbc.M407528200. PMID 15809304.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Ekim 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). ss. 1173-8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

Dış bağlantılar

Human ARFIP230 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genome location and ARFIP2^{[ölü/kırık bağlantı]} gene details page in the UCSC Genome Browser.

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132254 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
^ ^a ^b "Identification of a novel Rac1-interacting protein involved in membrane ruffling". The EMBO Journal. 15 (15). Ağustos 1996. ss. 3778-86.
^ ^a ^b "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". The Journal of Biological Chemistry. 272 (9). Şubat 1997. ss. 5421-9.
^ "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)". 5 Aralık 2010 tarihinde kaynağından arşivlendi.
^ "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". The EMBO Journal. 16 (17). Eylül 1997. ss. 5445-54.
^ "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochemical and Biophysical Research Communications. 285 (5). Ağustos 2001. ss. 1267-73.
^ "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature. 411 (6834). Mayıs 2001. ss. 215-9.