AHNAK
AHNAK | |||||||||||||||||
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Ідентифікатори | |||||||||||||||||
Символи | AHNAK, AHNAKRS, AHNAK nucleoprotein, PM227 | ||||||||||||||||
Зовнішні ІД | OMIM: 103390 MGI: 1316648 HomoloGene: 67425 GeneCards: AHNAK | ||||||||||||||||
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Шаблон експресії | |||||||||||||||||
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Більше даних | |||||||||||||||||
Ортологи | |||||||||||||||||
Види | Людина | Миша | |||||||||||||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (мРНК) |
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RefSeq (білок) |
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Локус (UCSC) | Хр. 11: 62.43 – 62.56 Mb | Хр. 19: 8.97 – 9.05 Mb | |||||||||||||||
PubMed search | [1] | [2] | |||||||||||||||
Вікідані | |||||||||||||||||
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AHNAK (англ. AHNAK nucleoprotein) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 5 890 амінокислот, а молекулярна маса — 629 101[4].
10 | 20 | 30 | 40 | 50 | ||||
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MEKEETTREL | LLPNWQGSGS | HGLTIAQRDD | GVFVQEVTQN | SPAARTGVVK | ||||
EGDQIVGATI | YFDNLQSGEV | TQLLNTMGHH | TVGLKLHRKG | DRSPEPGQTW | ||||
TREVFSSCSS | EVVLSGDDEE | YQRIYTTKIK | PRLKSEDGVE | GDLGETQSRT | ||||
ITVTRRVTAY | TVDVTGREGA | KDIDISSPEF | KIKIPRHELT | EISNVDVETQ | ||||
SGKTVIRLPS | GSGAASPTGS | AVDIRAGAIS | ASGPELQGAG | HSKLQVTMPG | ||||
IKVGGSGVNV | NAKGLDLGGR | GGVQVPAVDI | SSSLGGRAVE | VQGPSLESGD | ||||
HGKIKFPTMK | VPKFGVSTGR | EGQTPKAGLR | VSAPEVSVGH | KGGKPGLTIQ | ||||
APQLEVSVPS | ANIEGLEGKL | KGPQITGPSL | EGDLGLKGAK | PQGHIGVDAS | ||||
APQIGGSITG | PSVEVQAPDI | DVQGPGSKLN | VPKMKVPKFS | VSGAKGEETG | ||||
IDVTLPTGEV | TVPGVSGDVS | LPEIATGGLE | GKMKGTKVKT | PEMIIQKPKI | ||||
SMQDVDLSLG | SPKLKGDIKV | SAPGVQGDVK | GPQVALKGSR | VDIETPNLEG | ||||
TLTGPRLGSP | SGKTGTCRIS | MSEVDLNVAA | PKVKGGVDVT | LPRVEGKVKV | ||||
PEVDVRGPKV | DVSAPDVEAH | GPEWNLKMPK | MKMPTFSTPG | AKGEGPDVHM | ||||
TLPKGDISIS | GPKVNVEAPD | VNLEGLGGKL | KGPDVKLPDM | SVKTPKISMP | ||||
DVDLHVKGTK | VKGEYDVTVP | KLEGELKGPK | VDIDAPDVDV | HGPDWHLKMP | ||||
KMKMPKFSVP | GFKAEGPEVD | VNLPKADVDI | SGPKIDVTAP | DVSIEEPEGK | ||||
LKGPKFKMPE | MNIKVPKISM | PDVDLHLKGP | NVKGEYDVTM | PKVESEIKVP | ||||
DVELKSAKMD | IDVPDVEVQG | PDWHLKMPKM | KMPKFSMPGF | KAEGPEVDVN | ||||
LPKADVDISG | PKVGVEVPDV | NIEGPEGKLK | GPKFKMPEMN | IKAPKISMPD | ||||
VDLHMKGPKV | KGEYDMTVPK | LEGDLKGPKV | DVSAPDVEMQ | GPDWNLKMPK | ||||
IKMPKFSMPS | LKGEGPEFDV | NLSKANVDIS | APKVDTNAPD | LSLEGPEGKL | ||||
KGPKFKMPEM | HFRAPKMSLP | DVDLDLKGPK | MKGNVDISAP | KIEGEMQVPD | ||||
VDIRGPKVDI | KAPDVEGQGL | DWSLKIPKMK | MPKFSMPSLK | GEGPEVDVNL | ||||
PKADVVVSGP | KVDIEAPDVS | LEGPEGKLKG | PKFKMPEMHF | KTPKISMPDV | ||||
DLHLKGPKVK | GDVDVSVPKV | EGEMKVPDVE | IKGPKMDIDA | PDVEVQGPDW | ||||
HLKMPKMKMP | KFSMPGFKGE | GREVDVNLPK | ADIDVSGPKV | DVEVPDVSLE | ||||
GPEGKLKGPK | FKMPEMHFKA | PKISMPDVDL | NLKGPKLKGD | VDVSLPEVEG | ||||
EMKVPDVDIK | GPKVDISAPD | VDVHGPDWHL | KMPKVKMPKF | SMPGFKGEGP | ||||
EVDVKLPKAD | VDVSGPKMDA | EVPDVNIEGP | DAKLKGPKFK | MPEMSIKPQK | ||||
ISIPDVGLHL | KGPKMKGDYD | VTVPKVEGEI | KAPDVDIKGP | KVDINAPDVE | ||||
VHGPDWHLKM | PKVKMPKFSM | PGFKGEGPEV | DMNLPKADLG | VSGPKVDIDV | ||||
PDVNLEAPEG | KLKGPKFKMP | SMNIQTHKIS | MPDVGLNLKA | PKLKTDVDVS | ||||
LPKVEGDLKG | PEIDVKAPKM | DVNVGDIDIE | GPEGKLKGPK | FKMPEMHFKA | ||||
PKISMPDVDL | HLKGPKVKGD | MDVSVPKVEG | EMKVPDVDIK | GPKVDIDAPD | ||||
VEVHDPDWHL | KMPKMKMPKF | SMPGFKAEGP | EVDVNLPKAD | IDVSGPSVDT | ||||
DAPDLDIEGP | EGKLKGSKFK | MPKLNIKAPK | VSMPDVDLNL | KGPKLKGEID | ||||
ASVPELEGDL | RGPQVDVKGP | FVEAEVPDVD | LECPDAKLKG | PKFKMPEMHF | ||||
KAPKISMPDV | DLHLKGPKVK | GDADVSVPKL | EGDLTGPSVG | VEVPDVELEC | ||||
PDAKLKGPKF | KMPDMHFKAP | KISMPDVDLH | LKGPKVKGDV | DVSVPKLEGD | ||||
LTGPSVGVEV | PDVELECPDA | KLKGPKFKMP | EMHFKTPKIS | MPDVDLHLKG | ||||
PKVKGDMDVS | VPKVEGEMKV | PDVDIKGPKM | DIDAPDVDVH | GPDWHLKMPK | ||||
MKMPKFSMPG | FKAEGPEVDV | NLPKADVVVS | GPKVDVEVPD | VSLEGPEGKL | ||||
KGPKLKMPEM | HFKAPKISMP | DVDLHLKGPK | VKGDVDVSLP | KLEGDLTGPS | ||||
VDVEVPDVEL | ECPDAKLKGP | KFKMPEMHFK | TPKISMPDVN | LNLKGPKVKG | ||||
DMDVSVPKVE | GEMKVPDVDI | RGPKVDIDAP | DVDVHGPDWH | LKMPKMKMPK | ||||
FSMPGFKGEG | PEVDVNLPKA | DVDVSGPKVD | VEVPDVSLEG | PEGKLKGPKF | ||||
KMPEMHFKTP | KISMPDVDFN | LKGPKIKGDV | DVSAPKLEGE | LKGPELDVKG | ||||
PKLDADMPEV | AVEGPNGKWK | TPKFKMPDMH | FKAPKISMPD | LDLHLKSPKA | ||||
KGEVDVDVPK | LEGDLKGPHV | DVSGPDIDIE | GPEGKLKGPK | FKMPDMHFKA | ||||
PNISMPDVDL | NLKGPKIKGD | VDVSVPEVEG | KLEVPDMNIR | GPKVDVNAPD | ||||
VQAPDWHLKM | PKMKMPKFSM | PGFKAEGPEV | DVNLPKADVD | ISGPKVDIEG | ||||
PDVNIEGPEG | KLKGPKLKMP | EMNIKAPKIS | MPDFDLHLKG | PKVKGDVDVS | ||||
LPKVEGDLKG | PEVDIKGPKV | DINAPDVGVQ | GPDWHLKMPK | VKMPKFSMPG | ||||
FKGEGPDGDV | KLPKADIDVS | GPKVDIEGPD | VNIEGPEGKL | KGPKFKMPEM | ||||
NIKAPKISMP | DIDLNLKGPK | VKGDVDVSLP | KVEGDLKGPE | VDIKGPKVDI | ||||
DAPDVDVHGP | DWHLKMPKIK | MPKISMPGFK | GEGPDVDVNL | PKADIDVSGP | ||||
KVDVECPDVN | IEGPEGKWKS | PKFKMPEMHF | KTPKISMPDI | DLNLTGPKIK | ||||
GDVDVTGPKV | EGDLKGPEVD | LKGPKVDIDV | PDVNVQGPDW | HLKMPKMKMP | ||||
KFSMPGFKAE | GPEVDVNLPK | ADVDVSGPKV | DVEGPDVNIE | GPEGKLKGPK | ||||
FKMPEMNIKA | PKIPMPDFDL | HLKGPKVKGD | VDISLPKVEG | DLKGPEVDIR | ||||
GPQVDIDVPD | VGVQGPDWHL | KMPKVKMPKF | SMPGFKGEGP | DVDVNLPKAD | ||||
LDVSGPKVDI | DVPDVNIEGP | EGKLKGPKFK | MPEMNIKAPK | ISMPDIDLNL | ||||
KGPKVKGDMD | VSLPKVEGDM | KVPDVDIKGP | KVDINAPDVD | VQGPDWHLKM | ||||
PKIKMPKISM | PGFKGEGPEV | DVNLPKADLD | VSGPKVDVDV | PDVNIEGPDA | ||||
KLKGPKFKMP | EMNIKAPKIS | MPDLDLNLKG | PKMKGEVDVS | LANVEGDLKG | ||||
PALDIKGPKI | DVDAPDIDIH | GPDAKLKGPK | LKMPDMHVNM | PKISMPEIDL | ||||
NLKGSKLKGD | VDVSGPKLEG | DIKAPSLDIK | GPEVDVSGPK | LNIEGKSKKS | ||||
RFKLPKFNFS | GSKVQTPEVD | VKGKKPDIDI | TGPKVDINAP | DVEVQGKVKG | ||||
SKFKMPFLSI | SSPKVSMPDV | ELNLKSPKVK | GDLDIAGPNL | EGDFKGPKVD | ||||
IKAPEVNLNA | PDVDVHGPDW | NLKMPKMKMP | KFSVSGLKAE | GPDVAVDLPK | ||||
GDINIEGPSM | NIEGPDLNVE | GPEGGLKGPK | FKMPDMNIKA | PKISMPDIDL | ||||
NLKGPKVKGD | VDISLPKLEG | DLKGPEVDIK | GPKVDINAPD | VDVHGPDWHL | ||||
KMPKVKMPKF | SMPGFKGEGP | EVDVTLPKAD | IDISGPNVDV | DVPDVNIEGP | ||||
DAKLKGPKFK | MPEMNIKAPK | ISMPDFDLNL | KGPKMKGDVV | VSLPKVEGDL | ||||
KGPEVDIKGP | KVDIDTPDIN | IEGSEGKFKG | PKFKIPEMHL | KAPKISMPDI | ||||
DLNLKGPKVK | GDVDVSLPKM | EGDLKGPEVD | IKGPKVDINA | PDVDVQGPDW | ||||
HLKMPKVKMP | KFSMPGFKGE | GPDVDVNLPK | ADLDVSGPKV | DIDVPDVNIE | ||||
GPEGKLKGPK | FKMPEMNIKA | PKISMPDIDL | NLKGPKVKGD | MDVSLPKVEG | ||||
DMQVPDLDIK | GPKVDINAPD | VDVRGPDWHL | KMPKIKMPKI | SMPGFKGEGP | ||||
EVDVNLPKAD | LDVSGPKVDV | DVPDVNIEGP | DAKLKGPKFK | MPEMNIKAPK | ||||
ISMPDFDLHL | KGPKVKGDVD | VSLPKMEGDL | KAPEVDIKGP | KVDIDAPDVD | ||||
VHGPDWHLKM | PKVKMPKFSM | PGFKGEGPEV | DVNLPKADID | VSGPKVDIDT | ||||
PDIDIHGPEG | KLKGPKFKMP | DLHLKAPKIS | MPEVDLNLKG | PKMKGDVDVS | ||||
LPKVEGDLKG | PEVDIKGPKV | DIDVPDVDVQ | GPDWHLKMPK | VKMPKFSMPG | ||||
FKGEGPDVDV | NLPKADLDVS | GPKVDIDVPD | VNIEGPDAKL | KGPKFKMPEM | ||||
NIKAPKISMP | DFDLHLKGPK | VKGDVDVSLP | KVEGDLKGPE | VDIKGPKVDI | ||||
DAPDVDVHGP | DWHLKMPKVK | MPKFSMPGFK | GEGPDVDVTL | PKADIEISGP | ||||
KVDIDAPDVS | IEGPDAKLKG | PKFKMPEMNI | KAPKISMPDI | DFNLKGPKVK | ||||
GDVDVSLPKV | EGDLKGPEID | IKGPSLDIDT | PDVNIEGPEG | KLKGPKFKMP | ||||
EMNIKAPKIS | MPDFDLHLKG | PKVKGDVDVS | LPKVESDLKG | PEVDIEGPEG | ||||
KLKGPKFKMP | DVHFKSPQIS | MSDIDLNLKG | PKIKGDMDIS | VPKLEGDLKG | ||||
PKVDVKGPKV | GIDTPDIDIH | GPEGKLKGPK | FKMPDLHLKA | PKISMPEVDL | ||||
NLKGPKVKGD | MDISLPKVEG | DLKGPEVDIR | DPKVDIDVPD | VDVQGPDWHL | ||||
KMPKVKMPKF | SMPGFKGEGP | DVDVNLPKAD | IDVSGPKVDV | DVPDVNIEGP | ||||
DAKLKGPKFK | MPEMSIKAPK | ISMPDIDLNL | KGPKVKGDVD | VTLPKVEGDL | ||||
KGPEADIKGP | KVDINTPDVD | VHGPDWHLKM | PKVKMPKFSM | PGFKGEGPDV | ||||
DVSLPKADID | VSGPKVDVDI | PDVNIEGPDA | KLKGPKFKMP | EINIKAPKIS | ||||
IPDVDLDLKG | PKVKGDFDVS | VPKVEGTLKG | PEVDLKGPRL | DFEGPDAKLS | ||||
GPSLKMPSLE | ISAPKVTAPD | VDLHLKAPKI | GFSGPKLEGG | EVDLKGPKVE | ||||
APSLDVHMDS | PDINIEGPDV | KIPKFKKPKF | GFGAKSPKAD | IKSPSLDVTV | ||||
PEAELNLETP | EISVGGKGKK | SKFKMPKIHM | SGPKIKAKKQ | GFDLNVPGGE | ||||
IDASLKAPDV | DVNIAGPDAA | LKVDVKSPKT | KKTMFGKMYF | PDVEFDIKSP | ||||
KFKAEAPLPS | PKLEGELQAP | DLELSLPAIH | VEGLDIKAKA | PKVKMPDVDI | ||||
SVPKIEGDLK | GPKVQANLGA | PDINIEGLDA | KVKTPSFGIS | APQVSIPDVN | ||||
VNLKGPKIKG | DVPSVGLEGP | DVDLQGPEAK | IKFPKFSMPK | IGIPGVKMEG | ||||
GGAEVHAQLP | SLEGDLRGPD | VKLEGPDVSL | KGPGVDLPSV | NLSMPKVSGP | ||||
DLDLNLKGPS | LKGDLDASVP | SMKVHAPGLN | LSGVGGKMQV | GGDGVKVPGI | ||||
DATTKLNVGA | PDVTLRGPSL | QGDLAVSGDI | KCPKVSVGAP | DLSLEASEGS | ||||
IKLPKMKLPQ | FGISTPGSDL | HVNAKGPQVS | GELKGPGVDV | NLKGPRISAP | ||||
NVDFNLEGPK | VKGSLGATGE | IKGPTVGGGL | PGIGVQGLEG | NLQMPGIKSS | ||||
GCDVNLPGVN | VKLPTGQISG | PEIKGGLKGS | EVGFHGAAPD | ISVKGPAFNM | ||||
ASPESDFGIN | LKGPKIKGGA | DVSGGVSAPD | ISLGEGHLSV | KGSGGEWKGP | ||||
QVSSALNLDT | SKFAGGLHFS | GPKVEGGVKG | GQIGLQAPGL | SVSGPQGHLE | ||||
SGSGKVTFPK | MKIPKFTFSG | RELVGREMGV | DVHFPKAEAS | IQAGAGDGEW | ||||
EESEVKLKKS | KIKMPKFNFS | KPKGKGGVTG | SPEASISGSK | GDLKSSKASL | ||||
GSLEGEAEAE | ASSPKGKFSL | FKSKKPRHRS | NSFSDEREFS | GPSTPTGTLE | ||||
FEGGEVSLEG | GKVKGKHGKL | KFGTFGGLGS | KSKGHYEVTG | SDDETGKLQG | ||||
SGVSLASKKS | RLSSSSSNDS | GNKVGIQLPE | VELSVSTKKE |
Локалізований у ядрі.
Література
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
- Shtivelman E., Cohen F.E., Bishop J.M. (1992). A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure. Proc. Natl. Acad. Sci. U.S.A. 89: 5472—5476. PMID 1608957 DOI:10.1073/pnas.89.12.5472
- Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. (2006). A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat. Biotechnol. 24: 1285—1292. PMID 16964243 DOI:10.1038/nbt1240
- Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. (2008). Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. J. Proteome Res. 7: 5167—5176. PMID 19367720 DOI:10.1021/pr800500r
- Impens F., Radoshevich L., Cossart P., Ribet D. (2014). Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc. Natl. Acad. Sci. U.S.A. 111: 12432—12437. PMID 25114211 DOI:10.1073/pnas.1413825111
- Shtivelman E., Cohen F.E., Bishop J.M. (1993). Proc. Natl. Acad. Sci. U.S.A. 90: 4328—4328.
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Примітки
Див. також
- Хромосома 11
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