| H2AFY |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1U35, 1ZR3, 1ZR5, 2F8N, 2FXK, 3HQH, 3HSV, 3IID, 3IIF, 3IVB, 5IIT | | |
| Ідентифікатори |
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| Символи | MACROH2A1, H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2, H2A histone family member Y, H2AFY, macroH2A.1 histone |
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| Зовнішні ІД | OMIM: 610054 MGI: 1349392 HomoloGene: 3598 GeneCards: MACROH2A1 |
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| Онтологія гена |
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| Молекулярна функція | • protein kinase binding
• rDNA binding
• protein serine/threonine kinase inhibitor activity
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• chromatin binding
• double-stranded methylated DNA binding
• protein heterodimerization activity
• RNA polymerase II core promoter sequence-specific DNA binding
• core promoter sequence-specific DNA binding
• DNA binding
• chromatin DNA binding
• enzyme binding
• GO:0001948, GO:0016582 protein binding
• nucleosomal DNA binding
• promoter-specific chromatin binding
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| Клітинна компонента | • екзосома
• ESC/E(Z) complex
• ядерце
• condensed chromosome
• хромосома
• pericentric heterochromatin
• Нуклеосома
• клітинне ядро
• nuclear chromosome
• sex chromatin
• Тільце Барра
• Хроматин
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| Біологічний процес | • negative regulation of histone H3-K4 methylation
• regulation of ribosomal DNA heterochromatin assembly
• Дозова компенсація
• negative regulation of cell cycle G2/M phase transition
• epigenetic maintenance of chromatin in transcription-competent conformation
• regulation of cell growth
• positive regulation of keratinocyte differentiation
• negative regulation of protein serine/threonine kinase activity
• GO:1901227 negative regulation of transcription by RNA polymerase II
• nucleosome assembly
• negative regulation of protein localization to chromosome, telomeric region
• negative regulation of gene expression, epigenetic
• negative regulation of histone H3-K27 methylation
• Епігенетичне успадкування
• positive regulation of maintenance of mitotic sister chromatid cohesion
• establishment of protein localization to chromatin
• negative regulation of transcription of nucleolar large rRNA by RNA polymerase I
• regulation of lipid metabolic process
• regulation of response to oxidative stress
• negative regulation of response to oxidative stress
• positive regulation of response to oxidative stress
• GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_001040158
NM_004893
NM_138609
NM_138610 |
| | NM_001159513
NM_001159514
NM_001159515
NM_012015 |
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| RefSeq (білок) | | NP_001035248
NP_004884
NP_613075
NP_613258 |
| | NP_001152985
NP_001152986
NP_001152987
NP_036145 |
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| Локус (UCSC) | Хр. 5: 135.33 – 135.4 Mb | Хр. 13: 56.22 – 56.28 Mb |
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| PubMed search | [1] | [2] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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