H2AFY |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Protein_H2AFY_PDB_1u35.png/250px-Protein_H2AFY_PDB_1u35.png) |
Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1U35, 1ZR3, 1ZR5, 2F8N, 2FXK, 3HQH, 3HSV, 3IID, 3IIF, 3IVB, 5IIT | | |
Ідентифікатори |
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Символи | MACROH2A1, H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2, H2A histone family member Y, H2AFY, macroH2A.1 histone |
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Зовнішні ІД | OMIM: 610054 MGI: 1349392 HomoloGene: 3598 GeneCards: MACROH2A1 |
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Онтологія гена |
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Молекулярна функція | • protein kinase binding • rDNA binding • protein serine/threonine kinase inhibitor activity • RNA polymerase II transcription regulatory region sequence-specific DNA binding • chromatin binding • double-stranded methylated DNA binding • protein heterodimerization activity • RNA polymerase II core promoter sequence-specific DNA binding • core promoter sequence-specific DNA binding • DNA binding • chromatin DNA binding • enzyme binding • GO:0001948, GO:0016582 protein binding • nucleosomal DNA binding • promoter-specific chromatin binding |
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Клітинна компонента | • екзосома • ESC/E(Z) complex • ядерце • condensed chromosome • хромосома • pericentric heterochromatin • Нуклеосома • клітинне ядро • nuclear chromosome • sex chromatin • Тільце Барра • Хроматин |
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Біологічний процес | • negative regulation of histone H3-K4 methylation • regulation of ribosomal DNA heterochromatin assembly • Дозова компенсація • negative regulation of cell cycle G2/M phase transition • epigenetic maintenance of chromatin in transcription-competent conformation • regulation of cell growth • positive regulation of keratinocyte differentiation • negative regulation of protein serine/threonine kinase activity • GO:1901227 negative regulation of transcription by RNA polymerase II • nucleosome assembly • negative regulation of protein localization to chromosome, telomeric region • negative regulation of gene expression, epigenetic • negative regulation of histone H3-K27 methylation • Епігенетичне успадкування • positive regulation of maintenance of mitotic sister chromatid cohesion • establishment of protein localization to chromatin • negative regulation of transcription of nucleolar large rRNA by RNA polymerase I • regulation of lipid metabolic process • regulation of response to oxidative stress • negative regulation of response to oxidative stress • positive regulation of response to oxidative stress • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b2/PBB_GE_H2AFY_214500_at_fs.png/250px-PBB_GE_H2AFY_214500_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/PBB_GE_H2AFY_214501_s_at_fs.png/250px-PBB_GE_H2AFY_214501_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/b/bf/PBB_GE_H2AFY_207168_s_at_fs.png/250px-PBB_GE_H2AFY_207168_s_at_fs.png) |
Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_001040158 NM_004893 NM_138609 NM_138610 |
| | NM_001159513 NM_001159514 NM_001159515 NM_012015 |
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RefSeq (білок) | | NP_001035248 NP_004884 NP_613075 NP_613258 |
| | NP_001152985 NP_001152986 NP_001152987 NP_036145 |
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Локус (UCSC) | Хр. 5: 135.33 – 135.4 Mb | Хр. 13: 56.22 – 56.28 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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