MUC5B |
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Ідентифікатори |
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Символи | MUC5B, MG1, MUC-5B, MUC5, MUC9, mucin 5B, oligomeric mucus/gel-forming |
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Зовнішні ІД | OMIM: 600770 MGI: 1921430 HomoloGene: 136756 GeneCards: MUC5B |
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Онтологія гена |
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Молекулярна функція | • GO:0001948, GO:0016582 protein binding |
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Клітинна компонента | • Golgi lumen • extracellular region • екзосома • внутрішньоклітинна мембранна органела • клітинна мембрана • міжклітинний простір |
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Біологічний процес | • O-glycan processing • stimulatory C-type lectin receptor signaling pathway |
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Джерела:Amigo / QuickGO | |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 11: 1.22 – 1.26 Mb | Хр. 7: 141.39 – 141.43 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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MUC5B (англ. Mucin 5B, oligomeric mucus/gel-forming) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 5 762 амінокислот, а молекулярна маса — 596 340[4].
Послідовність амінокислот
10 | | 20 | | 30 | | 40 | | 50 |
MGAPSACRTL | | VLALAAMLVV | | PQAETQGPVE | | PSWENAGHTM | | DGGAPTSSPT |
RRVSFVPPVT | | VFPSLSPLNP | | AHNGRVCSTW | | GDFHYKTFDG | | DVFRFPGLCN |
YVFSEHCRAA | | YEDFNVQLRR | | GLVGSRPVVT | | RVVIKAQGLV | | LEASNGSVLI |
NGQREELPYS | | RTGLLVEQSG | | DYIKVSIRLV | | LTFLWNGEDS | | ALLELDPKYA |
NQTCGLCGDF | | NGLPAFNEFY | | AHNARLTPLQ | | FGNLQKLDGP | | TEQCPDPLPL |
PAGNCTDEEG | | ICHRTLLGPA | | FAECHALVDS | | TAYLAACAQD | | LCRCPTCPCA |
TFVEYSRQCA | | HAGGQPRNWR | | CPELCPRTCP | | LNMQHQECGS | | PCTDTCSNPQ |
RAQLCEDHCV | | DGCFCPPGTV | | LDDITHSGCL | | PLGQCPCTHG | | GRTYSPGTSF |
NTTCSSCTCS | | GGLWQCQDLP | | CPGTCSVQGG | | AHISTYDEKL | | YDLHGDCSYV |
LSKKCADSSF | | TVLAELRKCG | | LTDNENCLKA | | VTLSLDGGDT | | AIRVQADGGV |
FLNSIYTQLP | | LSAANITLFT | | PSSFFIVVQT | | GLGLQLLVQL | | VPLMQVFVRL |
DPAHQGQMCG | | LCGNFNQNQA | | DDFTALSGVV | | EATGAAFANT | | WKAQAACANA |
RNSFEDPCSL | | SVENENYARH | | WCSRLTDPNS | | AFSRCHSIIN | | PKPFHSNCMF |
DTCNCERSED | | CLCAALSSYV | | HACAAKGVQL | | SDWRDGVCTK | | YMQNCPKSQR |
YAYVVDACQP | | TCRGLSEADV | | TCSVSFVPVD | | GCTCPAGTFL | | NDAGACVPAQ |
ECPCYAHGTV | | LAPGEVVHDE | | GAVCSCTGGK | | LSCLGASLQK | | STGCAAPMVY |
LDCSNSSAGT | | PGAECLRSCH | | TLDVGCFSTH | | CVSGCVCPPG | | LVSDGSGGCI |
AEEDCPCVHN | | EATYKPGETI | | RVDCNTCTCR | | NRRWECSHRL | | CLGTCVAYGD |
GHFITFDGDR | | YSFEGSCEYI | | LAQDYCGDNT | | THGTFRIVTE | | NIPCGTTGTT |
CSKAIKLFVE | | SYELILQEGT | | FKAVARGPGG | | DPPYKIRYMG | | IFLVIETHGM |
AVSWDRKTSV | | FIRLHQDYKG | | RVCGLCGNFD | | DNAINDFATR | | SRSVVGDALE |
FGNSWKLSPS | | CPDALAPKDP | | CTANPFRKSW | | AQKQCSILHG | | PTFAACRSQV |
DSTKYYEACV | | NDACACDSGG | | DCECFCTAVA | | AYAQACHDAG | | LCVSWRTPDT |
CPLFCDFYNP | | HGGCEWHYQP | | CGAPCLKTCR | | NPSGHCLVDL | | PGLEGCYPKC |
PPSQPFFNED | | QMKCVAQCGC | | YDKDGNYYDV | | GARVPTAENC | | QSCNCTPSGI |
QCAHSLEACT | | CTYEDRTYSY | | QDVIYNTTDG | | LGACLIAICG | | SNGTIIRKAV |
ACPGTPATTP | | FTFTTAWVPH | | STTSPALPVS | | TVCVREVCRW | | SSWYNGHRPE |
PGLGGGDFET | | FENLRQRGYQ | | VCPVLADIEC | | RAAQLPDMPL | | EELGQQVDCD |
RMRGLMCANS | | QQSPPLCHDY | | ELRVLCCEYV | | PCGPSPAPGT | | SPQPSLSAST |
EPAVPTPTQT | | TATEKTTLWV | | TPSIRSTAAL | | TSQTGSSSGP | | VTVTPSAPGT |
TTCQPRCQWT | | EWFDEDYPKS | | EQLGGDVESY | | DKIRAAGGHL | | CQQPKDIECQ |
AESFPNWTLA | | QVGQKVHCDV | | HFGLVCRNWE | | QEGVFKMCYN | | YRIRVLCCSD |
DHCRGRATTP | | PPTTELETAT | | TTTTQALFST | | PQPTSSPGLT | | RAPPASTTAV |
PTLSEGLTSP | | RYTSTLGTAT | | TGGPTTPAGS | | TEPTVPGVAT | | STLPTRSALP |
GTTGSLGTWR | | PSQPPTLAPT | | TMATSRARPT | | GTASTASKEP | | LTTSLAPTLT |
SELSTSQAET | | STPRTETTMS | | PLTNTTTSQG | | TTRCQPKCEW | | TEWFDVDFPT |
SGVAGGDMET | | FENIRAAGGK | | MCWAPKSIEC | | RAENYPEVSI | | DQVGQVLTCS |
LETGLTCKNE | | DQTGRFNMCF | | NYNVRVLCCD | | DYSHCPSTPA | | TSSTATPSST |
PGTTWILTKP | | TTTATTTAST | | GSTATPTSTL | | RTAPPPKVLT | | TTATTPTVTS |
SKATPSSSPG | | TATALPALRS | | TATTPTATSV | | TPIPSSSLGT | | TWTRLSQTTT |
PTATMSTATP | | SSTPETAHTS | | TVLTATATTT | | GATGSVATPS | | STPGTAHTTK |
VPTTTTTGFT | | ATPSSSPGTA | | LTPPVWISTT | | TTPTTRGSTV | | TPSSIPGTTH |
TATVLTTTTT | | TVATGSMATP | | SSSTQTSGTP | | PSLTTTATTI | | TATGSTTNPS |
STPGTTPIPP | | VLTTTATTPA | | ATSNTVTPSS | | ALGTTHTPPV | | PNTMATTHGR |
SLPPSSPHTV | | RTAWTSATSG | | ILGTTHITEP | | STVTSHTLAA | | TTGTTQHSTP |
ALSSPHPSSR | | TTESPPSPGT | | TTPGHTTATS | | RTTATATPSK | | TRTSTLLPSS |
PTSAPITTVV | | TMGCEPQCAW | | SEWLDYSYPM | | PGPSGGDFDT | | YSNIRAAGGA |
VCEQPLGLEC | | RAQAQPGVPL | | RELGQVVECS | | LDFGLVCRNR | | EQVGKFKMCF |
NYEIRVFCCN | | YGHCPSTPAT | | SSTAMPSSTP | | GTTWILTELT | | TTATTTESTG |
STATPSSTPG | | TTWILTEPST | | TATVTVPTGS | | TATASSTQAT | | AGTPHVSTTA |
TTPTVTSSKA | | TPFSSPGTAT | | ALPALRSTAT | | TPTATSFTAI | | PSSSLGTTWT |
RLSQTTTPTA | | TMSTATPSST | | PETVHTSTVL | | TTTATTTGAT | | GSVATPSSTP |
GTAHTTKVLT | | TTTTGFTATP | | SSSPGTARTL | | PVWISTTTTP | | TTRGSTVTPS |
SIPGTTHTPT | | VLTTTTTTVA | | TGSMATPSSS | | TQTSGTPPSL | | TTTATTITAT |
GSTTNPSSTP | | GTTPIPPVLT | | TTATTPAATS | | STVTPSSALG | | TTHTPPVPNT |
TATTHGRSLS | | PSSPHTVRTA | | WTSATSGTLG | | TTHITEPSTG | | TSHTPAATTG |
TTQHSTPALS | | SPHPSSRTTE | | SPPSPGTTTP | | GHTRATSRTT | | ATATPSKTRT |
STLLPSSPTS | | APITTVVTMG | | CEPQCAWSEW | | LDYSYPMPGP | | SGGDFDTYSN |
IRAAGGAVCE | | QPLGLECRAQ | | AQPGVPLREL | | GQVVECSLDF | | GLVCRNREQV |
GKFKMCFNYE | | IRVFCCNYGH | | CPSTPATSST | | ATPSSTPGTT | | WILTEQTTAA |
TTTATTGSTA | | IPSSTPGTAP | | PPKVLTSTAT | | TPTATSSKAT | | SSSSPRTATT |
LPVLTSTATK | | STATSFTPIP | | SFTLGTTGTL | | PEQTTTPMAT | | MSTIHPSSTP |
ETTHTSTVLT | | TKATTTRATS | | SMSTPSSTPG | | TTWILTELTT | | AATTTAATGP |
TATPSSTPGT | | TWILTEPSTT | | ATVTVPTGST | | ATASSTRATA | | GTLKVLTSTA |
TTPTVISSRA | | TPSSSPGTAT | | ALPALRSTAT | | TPTATSVTAI | | PSSSLGTAWT |
RLSQTTTPTA | | TMSTATPSST | | PETVHTSTVL | | TTTTTTTRAT | | GSVATPSSTP |
GTAHTTKVPT | | TTTTGFTATP | | SSSPGTALTP | | PVWISTTTTP | | TTRGSTVTPS |
SIPGTTHTAT | | VLTTTTTTVA | | TGSMATPSSS | | TQTSGTPPSL | | TTTATTITAT |
GSTTNPSSTP | | GTTPIPPVLT | | TTATTPAATS | | STVTPSSALG | | TTHTPPVPNT |
TATTHGRSLP | | PSSPHTVRTA | | WTSATSGILG | | TTHITEPSTV | | TSHTPAATTS |
TTQHSTPALS | | SPHPSSRTTE | | SPPSPGTTTP | | GHTRGTSRTT | | ATATPSKTRT |
STLLPSSPTS | | APITTVVTTG | | CEPQCAWSEW | | LDYSYPMPGP | | SGGDFDTYSN |
IRAAGGAVCE | | QPLGLECRAQ | | AQPGVPLREL | | GQVVECSLDF | | GLVCRNREQV |
GKFKMCFNYE | | IRVFCCNYGH | | CPSTPATSST | | ATPSSTPGTT | | WILTKLTTTA |
TTTESTGSTA | | TPSSTPGTTW | | ILTEPSTTAT | | VTVPTGSTAT | | ASSTQATAGT |
PHVSTTATTP | | TVTSSKATPF | | SSPGTATALP | | ALRSTATTPT | | ATSFTAIPSS |
SLGTTWTRLS | | QTTTPTATMS | | TATPSSTPET | | AHTSTVLTTT | | ATTTRATGSV |
ATPSSTPGTA | | HTTKVPTTTT | | TGFTVTPSSS | | PGTARTPPVW | | ISTTTTPTTS |
GSTVTPSSVP | | GTTHTPTVLT | | TTTTTVATGS | | MATPSSSTQT | | SGTPPSLITT |
ATTITATGST | | TNPSSTPGTT | | PIPPVLTTTA | | TTPAATSSTV | | TPSSALGTTH |
TPPVPNTTAT | | THGRSLSPSS | | PHTVRTAWTS | | ATSGTLGTTH | | ITEPSTGTSH |
TPAATTGTTQ | | HSTPALSSPH | | PSSRTTESPP | | SPGTTTPGHT | | TATSRTTATA |
TPSKTRTSTL | | LPSSPTSAPI | | TTVVTTGCEP | | QCAWSEWLDY | | SYPMPGPSGG |
DFDTYSNIRA | | AGGAVCEQPL | | GLECRAQAQP | | GVPLGELGQV | | VECSLDFGLV |
CRNREQVGKF | | KMCFNYEIRV | | FCCNYGHCPS | | TPATSSTAMP | | SSTPGTTWIL |
TELTTTATTT | | ASTGSTATPS | | STPGTAPPPK | | VLTSPATTPT | | ATSSKATSSS |
SPRTATTLPV | | LTSTATKSTA | | TSVTPIPSST | | LGTTGTLPEQ | | TTTPVATMST |
IHPSSTPETT | | HTSTVLTTKA | | TTTRATSSTS | | TPSSTPGTTW | | ILTELTTAAT |
TTAATGPTAT | | PSSTPGTTWI | | LTELTTTATT | | TASTGSTATP | | SSTPGTTWIL |
TEPSTTATVT | | VPTGSTATAS | | STQATAGTPH | | VSTTATTPTV | | TSSKATPSSS |
PGTATALPAL | | RSTATTPTAT | | SFTAIPSSSL | | GTTWTRLSQT | | TTPTATMSTA |
TPSSTPETVH | | TSTVLTATAT | | TTGATGSVAT | | PSSTPGTAHT | | TKVPTTTTTG |
FTATPSSSPG | | TALTPPVWIS | | TTTTPTTTTP | | TTSGSTVTPS | | SIPGTTHTAR |
VLTTTTTTVA | | TGSMATPSSS | | TQTSGTPPSL | | TTTATTITAT | | GSTTNPSSTP |
GTTPITPVLT | | STATTPAATS | | SKATSSSSPR | | TATTLPVLTS | | TATKSTATSF |
TPIPSSTLWT | | TWTVPAQTTT | | PMSTMSTIHT | | SSTPETTHTS | | TVLTTTATMT |
RATNSTATPS | | STLGTTRILT | | ELTTTATTTA | | ATGSTATLSS | | TPGTTWILTE |
PSTIATVMVP | | TGSTATASST | | LGTAHTPKVV | | TTMATMPTAT | | ASTVPSSSTV |
GTTRTPAVLP | | SSLPTFSVST | | VSSSVLTTLR | | PTGFPSSHFS | | TPCFCRAFGQ |
FFSPGEVIYN | | KTDRAGCHFY | | AVCNQHCDID | | RFQGACPTSP | | PPVSSAPLSS |
PSPAPGCDNA | | IPLRQVNETW | | TLENCTVARC | | VGDNRVVLLD | | PKPVANVTCV |
NKHLPIKVSD | | PSQPCDFHYE | | CECICSMWGG | | SHYSTFDGTS | | YTFRGNCTYV |
LMREIHARFG | | NLSLYLDNHY | | CTASATAAAA | | RCPRALSIHY | | KSMDIVLTVT |
MVHGKEEGLI | | LFDQIPVSSG | | FSKNGVLVSV | | LGTTTMRVDI | | PALGVSVTFN |
GQVFQARLPY | | SLFHNNTEGQ | | CGTCTNNQRD | | DCLQRDGTTA | | ASCKDMAKTW |
LVPDSRKDGC | | WAPTGTPPTA | | SPAAPVSSTP | | TPTPCPPQPL | | CDLMLSQVFA |
ECHNLVPPGP | | FFNACISDHC | | RGRLEVPCQS | | LEAYAELCRA | | RGVCSDWRGA |
TGGLCDLTCP | | PTKVYKPCGP | | IQPATCNSRN | | QSPQLEGMAE | | GCFCPEDQIL |
FNAHMGICVQ | | ACPCVGPDGF | | PKFPGERWVS | | NCQSCVCDEG | | SVSVQCKPLP |
CDAQGQPPPC | | NRPGFVTVTR | | PRAENPCCPE | | TVCVCNTTTC | | PQSLPVCPPG |
QESICTQEEG | | DCCPTFRCRP | | QLCSYNGTFY | | GVGATFPGAL | | PCHMCTCLSG |
DTQDPTVQCQ | | EDACNNTTCP | | QGFEYKRVAG | | QCCGECVQTA | | CLTPDGQPVQ |
LNETWVNSHV | | DNCTVYLCEA | | EGGVHLLTPQ | | PASCPDVSSC | | RGSLRKTGCC |
YSCEEDSCQV | | RINTTILWHQ | | GCETEVNITF | | CEGSCPGASK | | YSAEAQAMQH |
QCTCCQERRV | | HEETVPLHCP | | NGSAILHTYT | | HVDECGCTPF | | CVPAPMAPPH |
TRGFPAQEAT | | AV |
Секретований назовні.
Література
- Chen Y., Zhao Y.H., Di Y.P., Wu R. (2001). Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region. Am. J. Respir. Cell Mol. Biol. 25: 542—553. PMID 11713095 DOI:10.1165/ajrcmb.25.5.4298
- Offner G.D., Nunes D.P., Keates A.C., Afdhal N.H., Troxler R.F. (1998). The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions. Biochem. Biophys. Res. Commun. 251: 350—355. PMID 9790959 DOI:10.1006/bbrc.1998.9469
- Desseyn J.-L., Buisine M.P., Porchet N., Aubert J.-P., Laine A. (1998). Genomic organization of the human mucin gene MUC5B: cDNA and genomic sequences upstream of the large central exon. J. Biol. Chem. 273: 30157—30164. PMID 9804771 DOI:10.1074/jbc.273.46.30157
- Desseyn J.-L., Guyonnet-Duperat V., Porchet N., Aubert J.-P., Laine A. (1997). Human mucin gene MUC5B, the 10.7 kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family. J. Biol. Chem. 272: 3168—3178. PMID 9013550 DOI:10.1074/jbc.272.6.3168
- Keates A.C., Nunes D.P., Afdhal N.H., Troxler R.F., Offner G.D. (1997). Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B. Biochem. J. 324: 295—303. PMID 9164870 DOI:10.1042/bj3240295
- Troxler R.F., Offner G.D., Zhang F., Iontcheva I., Oppenheim F.G. (1995). Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland. Biochem. Biophys. Res. Commun. 217: 1112—1119. PMID 8554565 DOI:10.1006/bbrc.1995.2884
Примітки
- ↑ Human PubMed Reference:.
- ↑ Mouse PubMed Reference:.
- ↑ HUGO Gene Nomenclature Commitee, HGNC:7516 (англ.) . Архів оригіналу за 14 жовтня 2017. Процитовано 8 вересня 2017.
- ↑ UniProt, Q9HC84 (англ.) . Архів оригіналу за 17 вересня 2017. Процитовано 8 вересня 2017.
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