PF4 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU | | |
Ідентифікатори |
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Символи | PF4, CXCL4, PF-4, SCYB4, platelet factor 4 |
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Зовнішні ІД | OMIM: 173460 MGI: 1888711 HomoloGene: 87791 GeneCards: PF4 |
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Онтологія гена |
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Молекулярна функція | • cytokine activity • heparin binding • CXCR3 chemokine receptor binding • chemokine activity • GO:0001948, GO:0016582 protein binding |
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Клітинна компонента | • extracellular region • platelet alpha granule lumen • міжклітинний простір • цитоплазма • collagen-containing extracellular matrix |
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Біологічний процес | • cytokine-mediated signaling pathway • chemokine-mediated signaling pathway • positive regulation of macrophage differentiation • platelet degranulation • negative regulation of megakaryocyte differentiation • positive regulation of cAMP-mediated signaling • negative regulation of MHC class II biosynthetic process • leukocyte chemotaxis • хемотаксис • response to lipopolysaccharide • positive regulation of macrophage derived foam cell differentiation • GO:1901313 positive regulation of gene expression • regulation of cell population proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • positive regulation of tumor necrosis factor production • negative regulation of angiogenesis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • inflammatory response • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cytolysis • platelet activation • defense response • positive regulation of neutrophil chemotaxis • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of megakaryocyte differentiation • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • neutrophil chemotaxis • cellular response to lipopolysaccharide |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 4: 73.98 – 73.98 Mb | Хр. 5: 90.92 – 90.92 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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