SFRP1

Ідентифікатори

Символи

SFRP1, FRP, FRP-1, FRP1, FrzA, SARP2, secreted frizzled related protein 1

Зовнішні ІД

OMIM: 604156 MGI: 892014 HomoloGene: 2266 GeneCards: SFRP1

Онтологія гена
Молекулярна функція	• GO:0005110 frizzled binding • GO:0001948, GO:0016582 protein binding • cysteine-type endopeptidase activity • identical protein binding • heparin binding • Wnt-protein binding • G protein-coupled receptor activity • Wnt-activated receptor activity
Клітинна компонента	• extracellular region • екзосома • cell surface • внутрішньоклітинний • GO:0005578 Позаклітинна матриця • клітинна мембрана • гіалоплазма • міжклітинний простір • integral component of membrane • collagen-containing extracellular matrix
Біологічний процес	• positive regulation of smoothened signaling pathway • cellular response to fibroblast growth factor stimulus • development of primary male sexual characteristics • somatic stem cell population maintenance • Wnt signaling pathway involved in somitogenesis • negative regulation of JUN kinase activity • somitogenesis • negative regulation of androgen receptor signaling pathway • menstrual cycle phase • negative regulation of bone remodeling • digestive tract morphogenesis • negative regulation of fibroblast apoptotic process • negative regulation of fibroblast proliferation • hematopoietic progenitor cell differentiation • negative regulation of epithelial cell proliferation • positive regulation of cell-matrix adhesion • cellular response to X-ray • cellular response to starvation • bone trabecula formation • cellular response to estradiol stimulus • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of Wnt signaling pathway • dopaminergic neuron differentiation • cellular response to interleukin-1 • positive regulation of non-canonical Wnt signaling pathway • positive regulation of cell population proliferation • positive regulation of stress fiber assembly • cellular response to hypoxia • regulation of branching involved in prostate gland morphogenesis • negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation • GO:1904578 response to organic cyclic compound • negative regulation of cell migration • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of osteoblast differentiation • negative regulation of epithelial to mesenchymal transition • negative regulation of BMP signaling pathway • negative regulation of peptidyl-tyrosine phosphorylation • positive regulation of extrinsic apoptotic signaling pathway • positive regulation of cell growth • regulation of cell cycle process • cellular response to vitamin D • hematopoietic stem cell differentiation • regulation of angiogenesis • male gonad development • dorsal/ventral axis specification • negative regulation of osteoclast differentiation • Wnt signaling pathway, planar cell polarity pathway • neural crest cell fate commitment • positive regulation of focal adhesion assembly • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of planar cell polarity pathway involved in axis elongation • кровотворення • ureteric bud development • cellular response to BMP stimulus • neural tube development • диференціація клітин • negative regulation of insulin secretion • osteoblast differentiation • positive regulation of fat cell differentiation • cellular response to transforming growth factor beta stimulus • stromal-epithelial cell signaling involved in prostate gland development • Wnt signaling pathway • cellular response to heparin • positive regulation of apoptotic process • cellular response to growth factor stimulus • positive regulation of fibroblast apoptotic process • canonical Wnt signaling pathway • negative regulation of cell growth • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • convergent extension involved in somitogenesis • multicellular organism development • negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis • planar cell polarity pathway involved in neural tube closure • negative regulation of osteoblast proliferation • anterior/posterior pattern specification • negative regulation of B cell differentiation • regulation of establishment of planar polarity • cellular response to tumor necrosis factor • female gonad development • negative regulation of cell population proliferation • negative regulation of apoptotic process • positive regulation of epithelial cell proliferation • neural tube closure • positive regulation of canonical Wnt signaling pathway • negative regulation of Wnt signaling pathway • negative regulation of ossification • negative regulation of gene expression • cellular response to estrogen stimulus • regulation of midbrain dopaminergic neuron differentiation • regulation of neuron projection development • cellular response to prostaglandin E stimulus • negative regulation of canonical Wnt signaling pathway • протеоліз • G protein-coupled receptor signaling pathway • non-canonical Wnt signaling pathway
Джерела:Amigo / QuickGO

Шаблон експресії

Більше даних

Ортологи

Види

Людина

Миша

Entrez


6422


20377

Ensembl


ENSG00000104332


ENSMUSG00000031548

UniProt


Q8N474


Q8C4U3

RefSeq (мРНК)


NM_003012


NM_013834

RefSeq (білок)


NP_003003


NP_038862

Локус (UCSC)

Хр. 8: 41.26 – 41.31 Mb

Хр. 8: 23.9 – 23.94 Mb

PubMed search

^[1]

^[2]

Вікідані

Див./Ред. для людей

Див./Ред. для мишей

SFRP1 (англ. Secreted frizzled related protein 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 8-ї хромосоми.^[3] Довжина поліпептидного ланцюга білка становить 314 амінокислот, а молекулярна маса — 35 386^[4].

Послідовність амінокислот

10	20	30	40	50
MGIGRSEGGR	RGAALGVLLA	LGAALLAVGS	ASEYDYVSFQ	SDIGPYQSGR
FYTKPPQCVD	IPADLRLCHN	VGYKKMVLPN	LLEHETMAEV	KQQASSWVPL
LNKNCHAGTQ	VFLCSLFAPV	CLDRPIYPCR	WLCEAVRDSC	EPVMQFFGFY
WPEMLKCDKF	PEGDVCIAMT	PPNATEASKP	QGTTVCPPCD	NELKSEAIIE
HLCASEFALR	MKIKEVKKEN	GDKKIVPKKK	KPLKLGPIKK	KDLKKLVLYL
KNGADCPCHQ	LDNLSHHFLI	MGRKVKSQYL	LTAIHKWDKK	NKEFKNFMKK
MKNHECPTFQ	SVFK

A: Аланін
C: Цистеїн
D: Аспарагінова кислота
E: Глутамінова кислота
F: Фенілаланін
G: Гліцин
H: Гістидин
I: Ізолейцин
K: Лізин
L: Лейцин
M: Метіонін
N: Аспарагін
P: Пролін
Q: Глутамін
R: Аргінін
S: Серин
T: Треонін
V: Валін
W: Триптофан

Y: Тирозин

Кодований геном білок за функцією належить до білків розвитку. Задіяний у таких біологічних процесах, як диференціація клітин, сигнальний шлях Wnt. Секретований назовні.

Література

Zhou Z., Wang J., Han X., Zhou J., Linder S. (1998). Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors. Int. J. Cancer. 78: 95—99. PMID 9724099 DOI:10.1002/(SICI)1097-0215(19980925)78:1<95::AID-IJC15>3.0.CO;2-4
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
Chong J.M., Ueren A., Rubin J.S., Speicher D.W. (2002). Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. J. Biol. Chem. 277: 5134—5144. PMID 11741940 DOI:10.1074/jbc.M108533200

Примітки

↑ Human PubMed Reference:.
↑ Mouse PubMed Reference:.
↑ HUGO Gene Nomenclature Commitee, HGNC:10776 (англ.) . Архів оригіналу за 11 вересня 2015. Процитовано 7 вересня 2017.
↑ UniProt, Q8N474 (англ.) . Архів оригіналу за 8 серпня 2017. Процитовано 7 вересня 2017.