组织蛋白酶W

组织蛋白酶W
識別號
别名CTSW;, LYPN, cathepsin W
外部IDOMIM:602364 MGI:1338045 HomoloGene:37471 GeneCards:CTSW
基因位置(人类
11號染色體
染色体11號染色體[1]
11號染色體
组织蛋白酶W的基因位置
组织蛋白酶W的基因位置
基因座11q13.1起始65,879,809 bp[1]
终止65,883,741 bp[1]
基因位置(小鼠
小鼠19号染色体
染色体小鼠19号染色体[2]
小鼠19号染色体
组织蛋白酶W的基因位置
组织蛋白酶W的基因位置
基因座19|19 A起始5,515,071 bp[2]
终止5,518,535 bp[2]
RNA表达模式
查阅更多表达数据
基因本體
分子功能 肽酶活性
cysteine-type endopeptidase activity
半胱氨酸型肽酶活性
水解酶活性
細胞組分 溶酶体

platelet dense granule lumen
細胞外區域
細胞外空間
内质网
生物學過程 proteolysis involved in cellular protein catabolic process
免疫反应
蛋白酶解
platelet degranulation
Sources:Amigo / QuickGO
直系同源
物種人類小鼠
Entrez

1521

13041

Ensembl

ENSG00000172543

ENSMUSG00000024910

UniProt

P56202

P56203

mRNA​序列

NM_001335

NM_009985

蛋白序列

NP_001326

NP_034115

基因位置​(UCSC)Chr 11: 65.88 – 65.88 MbChr 19: 5.52 – 5.52 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

组织蛋白酶W(英语:Cathepsin W)是一种在人体中由CTSW基因编码的蛋白质[5][6][7]

该基因编码的蛋白质是半胱氨酸组织蛋白酶肽酶C1家族的成员,是一种半胱氨酸蛋白酶组织蛋白酶,可能在T细胞溶细胞活性的机制或调节中具有特定功能。编码的蛋白质被发现与自然杀伤细胞细胞毒性T细胞内质网内的细胞膜有关。该基因的表达被白细胞介素2上调。[7]

参见

参考文献

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000172543 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000024910 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Linnevers C, Smeekens SP, Brömme D. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. FEBS Lett. May 1997, 405 (3): 253–9. PMID 9108299. S2CID 45420314. doi:10.1016/S0014-5793(97)00118-X可免费查阅. 
  6. ^ Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D. Genomic structure, chromosomal localization, and expression of human cathepsin W. Biochem Biophys Res Commun. Aug 1998, 248 (2): 255–61. PMID 9675123. doi:10.1006/bbrc.1998.8954. 
  7. ^ 7.0 7.1 Entrez Gene: CTSW cathepsin W. 

阅读

  • Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928可免费查阅. PMID 15489334. doi:10.1101/gr.2596504. 
  • Meinhardt C, Peitz U, Treiber G, et al. Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene.. Biochem. Biophys. Res. Commun. 2004, 321 (4): 975–80. PMID 15358123. doi:10.1016/j.bbrc.2004.07.056. 
  • Zhang Z, Henzel WJ. Signal peptide prediction based on analysis of experimentally verified cleavage sites.. Protein Sci. 2005, 13 (10): 2819–24. PMC 2286551可免费查阅. PMID 15340161. doi:10.1110/ps.04682504. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241可免费查阅. PMID 12477932. doi:10.1073/pnas.242603899可免费查阅. 
  • Buhling F, Kellner U, Guenther D, et al. Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract.. Biol. Chem. 2003, 383 (7–8): 1285–9. PMID 12437118. S2CID 23389714. doi:10.1515/BC.2002.144. 
  • Wex T, Bühling F, Wex H, et al. Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum.. J. Immunol. 2001, 167 (4): 2172–8. PMID 11490002. doi:10.4049/jimmunol.167.4.2172可免费查阅. 
  • Wex T, Levy B, Wex H, Brömme D. Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like cysteine proteases.. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 2000, 477: 271–80. ISBN 0-306-46383-0. PMID 10849754. doi:10.1007/0-306-46826-3_29. 
  • Brinkworth RI, Tort JF, Brindley PJ, Dalton JP. Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes.. Int. J. Biochem. Cell Biol. 2000, 32 (3): 373–84. PMID 10716634. doi:10.1016/S1357-2725(99)00129-6. 
  • Wex T, Levy B, Wex H, Brömme D. Human cathepsins F and W: A new subgroup of cathepsins.. Biochem. Biophys. Res. Commun. 1999, 259 (2): 401–7. PMID 10362521. doi:10.1006/bbrc.1999.0700. 
  • Brown J, Matutes E, Singleton A, et al. Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase.. Leukemia. 1998, 12 (11): 1771–81. PMID 9823953. doi:10.1038/sj.leu.2401164可免费查阅. 

外部链接

  • The MEROPS online database for peptidases and their inhibitors: C01.037[失效連結]
胱天蛋白酶
来自果实
钙蛋白酶
  • CAPN1
  • CAPN2
  • CAPN3
  • CAPN5
  • CAPN6
  • CAPN7
  • CAPN8
  • CAPN9
  • CAPN10
  • CAPN11
  • CAPN12
  • CAPN13
  • CAPN14
  • CAPNS1
  • CAPNS2
组织蛋白酶
其它
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3英语Template:Ligases CO CS and CN/4/5-6
活性
调节
分类
动力学
类型
  • EC1 氧化還原酶列表英语List of EC numbers (EC 1)
  • EC2 轉移酶列表英语List of EC numbers (EC 2)
  • EC3 水解酶列表英语List of EC numbers (EC 3)
  • EC4 裂合酶列表英语List of EC numbers (EC 4)
  • EC5 異構酶列表英语List of EC numbers (EC 5)
  • EC6 連接酶列表英语List of EC numbers (EC 6)
  • EC7 移位酶英语Translocase列表英语List of EC numbers (EC 7)