![](//upload.wikimedia.org/wikipedia/commons/thumb/8/8f/1bwn_opm.png/250px-1bwn_opm.png) 酪氨酸蛋白激酶BTK的PH结构域 |
鑑定 |
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標誌 | PH |
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Pfam | PF00169(旧版) |
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Pfam宗系 | CL0266(旧版) |
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InterPro(英语:InterPro) | IPR001849 |
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SMART(英语:Simple Modular Architecture Research Tool) | PH |
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PROSITE(英语:PROSITE) | PDOC50003 |
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SCOP(英语:Structural Classification of Proteins) | 1dyn / SUPFAM |
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OPM(英语:Orientations of Proteins in Membranes database)家族 | 49 |
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OPM(英语:Orientations of Proteins in Membranes database)蛋白 | 1pls |
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CDD(英语:Conserved Domain Database) | cd00821 |
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現有可用的蛋白結構: |
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Pfam | 結構(旧版) / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum(英语:PDBsum) | 結構概要 |
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PH结构域(英語:PH domain,全称普列克底物蛋白同源结构域,Pleckstrin homology domain)是一类蛋白质结构域,长约120个氨基酸,存在于涉及细胞内信号传导或作为细胞骨架成分的多种蛋白质中。[1][2][3][4][5][6][7]
参考文献
- ^ Mayer BJ, Ren R, Clark KL, Baltimore D. A putative modular domain present in diverse signaling proteins. Cell. May 1993, 73 (4): 629–30. PMID 8500161. S2CID 44282241. doi:10.1016/0092-8674(93)90244-K.
- ^ Haslam RJ, Koide HB, Hemmings BA. Pleckstrin domain homology. Nature. May 1993, 363 (6427): 309–10. PMID 8497315. S2CID 4334376. doi:10.1038/363309b0.
- ^ Musacchio A, Gibson T, Rice P, Thompson J, Saraste M. The PH domain: a common piece in the structural patchwork of signalling proteins. Trends in Biochemical Sciences. September 1993, 18 (9): 343–8. PMID 8236453. doi:10.1016/0968-0004(93)90071-T.
- ^ Gibson TJ, Hyvönen M, Musacchio A, Saraste M, Birney E. PH domain: the first anniversary. Trends in Biochemical Sciences. September 1994, 19 (9): 349–53. PMID 7985225. doi:10.1016/0968-0004(94)90108-2.
- ^ Pawson T. Protein modules and signalling networks. Nature. February 1995, 373 (6515): 573–80. PMID 7531822. S2CID 4324726. doi:10.1038/373573a0.
- ^ Ingley E, Hemmings BA. Pleckstrin homology (PH) domains in signal transduction. Journal of Cellular Biochemistry. December 1994, 56 (4): 436–43. PMID 7890802. doi:10.1002/jcb.240560403.
- ^ Saraste M, Hyvönen M. Pleckstrin homology domains: a fact file. Current Opinion in Structural Biology. June 1995, 5 (3): 403–8. PMID 7583640. doi:10.1016/0959-440X(95)80104-9.
外部链接
- Nash Lab Protein Interaction Domains - PH domain description[永久失效連結]
- Template:UMichOPM - Calculated orientations of PH domains in membranes
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| - 3H(英语:3H domain)
- ABM(英语:ABM domain)
- ACDC(英语:ACDC domain)
- ACT(英语:ACT domain)
- ADF-H(英语:ADF-H domain)
- ANTH(英语:ANTH domain)
- ARID(英语:ARID domain)
- BAR
- BEN(英语:BEN domain)
- BESS(英语:BESS domain)
- BIR(英语:Inhibitor of apoptosis domain)
- BMC(英语:BMC domain)
- BPS(英语:BPS domain)
- BTB/POZ(英语:BTB/POZ domain)
- BZIP(英语:BZIP domain)
- C1(英语:C1 domain)
- C2(英语:C2 domain)
- Cache(英语:Cache domain)
- CBS(英语:CBS domain)
- CGI-121(英语:Kinase binding protein CGI-121)
- CRM(英语:CRM domain)
- CUB(英语:CUB domain)
- CUT(英语:CUT domain)
- CVNH(英语:CVNH domain)
- 死亡(英语:Death fold)
- CARD(英语:CARD domain)
- DD(英语:Death domain)
- DED(英语:Death effector domain)
- Pyrin(英语:Pyrin domain)
- DEP
- DHHC(英语:DHHC domain)
- DHR1(英语:DHR1 domain)
- DHR2(英语:DHR2 domain)
- DM(英语:DM domain)
- EcoEI_R_C(英语:EcoEI R protein C-terminal domain)
- EF1(英语:EF1 guanine nucleotide exchange domain)
- ENTH
- FGGY(英语:FGGY carbohydrate kinase family)
- FYVE(英语:FYVE domain)
- HEAT(英语:HEAT repeat)
- Kringle(英语:Kringle domain)
- LIM
- LRR
- NACHT(英语:NACHT domain)
- PAS
- LOV(英语:Light-oxygen-voltage-sensing domain)
- PDZ(英语:PDZ domain)
- PH
- PX
- SH2
- SH3
- SUN
- TRIO(英语:CRAL-TRIO domain)
- WD40(英语:WD40 repeat)
- X8
- YTH(英语:YTH protein domain)
- 锌指
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