Protein-coding gene in the species Homo sapiens
CEP350 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/2/20/Protein_CEP350_PDB_2coz.png/250px-Protein_CEP350_PDB_2coz.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | CEP350, CAP350, GM133, centrosomal protein 350 |
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External IDs | OMIM: 617870; MGI: 1921331; HomoloGene: 8879; GeneCards: CEP350; OMA:CEP350 - orthologs |
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Gene location (Human) |
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![Chromosome 1 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png) | Chr. | Chromosome 1 (human)[1] |
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| Band | 1q25.2 | Start | 179,954,773 bp[1] |
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End | 180,114,875 bp[1] |
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Gene location (Mouse) |
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![Chromosome 1 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/Ideogram_house_mouse_chromosome_1.svg/260px-Ideogram_house_mouse_chromosome_1.svg.png) | Chr. | Chromosome 1 (mouse)[2] |
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| Band | 1|1 G3 | Start | 155,720,710 bp[2] |
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End | 155,849,001 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - sperm
- trabecular bone
- nipple
- left testis
- Achilles tendon
- right testis
- optic nerve
- pancreatic ductal cell
- jejunal mucosa
- gingival epithelium
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| Top expressed in | - medullary collecting duct
- epithelium of stomach
- ciliary body
- pyloric antrum
- retinal pigment epithelium
- triceps brachii muscle
- vastus lateralis muscle
- Epithelium of choroid plexus
- temporal muscle
- mucous cell of stomach
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/7/7d/PBB_GE_CEP350_213165_at_fs.png/250px-PBB_GE_CEP350_213165_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/3/3b/PBB_GE_CEP350_213956_at_fs.png/250px-PBB_GE_CEP350_213956_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/a/a3/PBB_GE_CEP350_204373_s_at_fs.png/250px-PBB_GE_CEP350_204373_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - microtubule binding
- protein binding
| Cellular component | - centrosome
- spindle
- cytoskeleton
- membrane
- nucleus
- microtubule organizing center
- cytoplasm
- cell projection
- centriole
| Biological process | | Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 179.95 – 180.11 Mb | Chr 1: 155.72 – 155.85 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.[5][6][7]
CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.[8]
It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000135837 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033671 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring". Mol Biol Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
- ^ Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350". J Cell Sci. 118 (Pt 1): 175–86. doi:10.1242/jcs.01600. PMID 15615782.
- ^ a b "Entrez Gene: CEP350 centrosomal protein 350kDa".
- ^ Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly". PLOS ONE. 3 (12): e3855. Bibcode:2008PLoSO...3.3855L. doi:10.1371/journal.pone.0003855. PMC 2586089. PMID 19052644.
External links
Further reading
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
- Makalowska I, Sood R, Faruque MU, et al. (2002). "Identification of six novel genes by experimental validation of GeneMachine predicted genes". Gene. 284 (1–2): 203–13. doi:10.1016/S0378-1119(01)00897-6. PMID 11891061.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Hoppeler-Lebel A, Celati C, Bellett G, et al. (2007). "Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex". J. Cell Sci. 120 (Pt 18): 3299–308. doi:10.1242/jcs.013102. PMID 17878239.
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