CNOT6L

Protein-coding gene in the species Homo sapiens
CNOT6L
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3NGN, 3NGO, 3NGQ, 5DV2

Identifiers
AliasesCNOT6L, CCR4b, CCR4-NOT transcription complex subunit 6 like
External IDsOMIM: 618069; MGI: 2443154; HomoloGene: 100830; GeneCards: CNOT6L; OMA:CNOT6L - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for CNOT6L
Genomic location for CNOT6L
Band4q21.1Start77,713,387 bp[1]
End77,819,615 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for CNOT6L
Genomic location for CNOT6L
Band5|5 E3Start96,218,192 bp[2]
End96,312,030 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • mucosa of ileum

  • superficial temporal artery

  • tibialis anterior muscle

  • bone marrow cells

  • thymus

  • corpus epididymis

  • tonsil

  • jejunal mucosa

  • epithelium of colon
Top expressed in
  • hair follicle

  • skin of external ear

  • Rostral migratory stream

  • secondary oocyte

  • primary oocyte

  • vas deferens

  • utricle

  • efferent ductule

  • blood

  • tibiofemoral joint
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • poly(A)-specific ribonuclease activity
  • metal ion binding
  • protein binding
  • nuclease activity
  • exonuclease activity
  • hydrolase activity
  • 3'-5'-exoribonuclease activity
Cellular component
  • cytoplasm
  • CCR4-NOT complex
  • nucleus
  • cytosol
Biological process
  • nuclear-transcribed mRNA poly(A) tail shortening
  • regulation of transcription, DNA-templated
  • RNA phosphodiester bond hydrolysis, exonucleolytic
  • mRNA processing
  • transcription, DNA-templated
  • positive regulation of cytoplasmic mRNA processing body assembly
  • mRNA destabilization
  • positive regulation of cell population proliferation
  • gene silencing
  • regulation of translation
  • nucleic acid phosphodiester bond hydrolysis
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

246175

231464

Ensembl

ENSG00000138767

ENSMUSG00000034724

UniProt

Q96LI5

Q8VEG6

RefSeq (mRNA)

NM_001286790
NM_144571
NM_001365006
NM_001365007

NM_001285511
NM_001285514
NM_144910
NM_178854

RefSeq (protein)

NP_001273719
NP_653172
NP_001351935
NP_001351936

NP_001272440
NP_001272443
NP_659159
NP_849185

Location (UCSC)Chr 4: 77.71 – 77.82 MbChr 5: 96.22 – 96.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex subunit 6 like is a protein that in humans is encoded by the CNOT6L gene.[5] It is a paralog of CNOT6 and therefore a potential subunit of the CCR4-Not deadenylase complex.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138767 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034724 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CCR4-NOT transcription complex subunit 6 like". Retrieved 2020-04-15.

Further reading

  • Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T (July 2007). "Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth". Mol. Cell. Biol. 27 (13): 4980–90. doi:10.1128/MCB.02304-06. PMC 1951489. PMID 17452450.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M, Yamamoto T, Rao Z (August 2010). "Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity". EMBO J. 29 (15): 2566–76. doi:10.1038/emboj.2010.152. PMC 2928688. PMID 20628353.
  • Naylor MG, Weiss ST, Lange C (September 2010). "A Bayesian approach to genetic association studies with family-based designs". Genet. Epidemiol. 34 (6): 569–74. doi:10.1002/gepi.20513. PMC 3349938. PMID 20818722.
  • Mittal S, Aslam A, Doidge R, Medica R, Winkler GS (March 2011). "The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence". Mol. Biol. Cell. 22 (6): 748–58. doi:10.1091/mbc.E10-11-0898. PMC 3057700. PMID 21233283.
  • Zhou W, Thiery JP (June 2013). "Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1". J. Cell Sci. 126 (Pt 12): 2740–6. doi:10.1242/jcs.126367. PMID 23591815.
  • Polesskaya A, Pinna G, Sassi Y, Vandamme M, Bigot A, Mouly V, Morozova N, Harel-Bellan A, Degerny C (February 2016). "Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation". Biochim. Biophys. Acta. 1863 (2): 263–70. doi:10.1016/j.bbamcr.2015.11.018. PMID 26608607.
  • Zhang Q, Yan D, Guo E, Ding B, Yang W, Liu R, Yamamoto T, Bartlam M (April 2016). "Structural basis for inhibition of the deadenylase activity of human CNOT6L". FEBS Lett. 590 (8): 1270–9. doi:10.1002/1873-3468.12160. PMID 27013054.
  • Morita M, Siddiqui N, Katsumura S, Rouya C, Larsson O, Nagashima T, Hekmatnejad B, Takahashi A, Kiyonari H, Zang M, St-Arnaud R, Oike Y, Giguère V, Topisirovic I, Okada-Hatakeyama M, Yamamoto T, Sonenberg N (April 2019). "Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis". Proc. Natl. Acad. Sci. U.S.A. 116 (16): 7973–7981. doi:10.1073/pnas.1816023116. PMC 6475422. PMID 30926667.


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