CNOT6L |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3NGN, 3NGO, 3NGQ, 5DV2 |
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Identifiers |
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Aliases | CNOT6L, CCR4b, CCR4-NOT transcription complex subunit 6 like |
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External IDs | OMIM: 618069; MGI: 2443154; HomoloGene: 100830; GeneCards: CNOT6L; OMA:CNOT6L - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 4 (human)[1] |
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| Band | 4q21.1 | Start | 77,713,387 bp[1] |
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End | 77,819,615 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5|5 E3 | Start | 96,218,192 bp[2] |
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End | 96,312,030 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - secondary oocyte
- mucosa of ileum
- superficial temporal artery
- tibialis anterior muscle
- bone marrow cells
- thymus
- corpus epididymis
- tonsil
- jejunal mucosa
- epithelium of colon
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| Top expressed in | - hair follicle
- skin of external ear
- Rostral migratory stream
- secondary oocyte
- primary oocyte
- vas deferens
- utricle
- efferent ductule
- blood
- tibiofemoral joint
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - poly(A)-specific ribonuclease activity
- metal ion binding
- protein binding
- nuclease activity
- exonuclease activity
- hydrolase activity
- 3'-5'-exoribonuclease activity
| Cellular component | - cytoplasm
- CCR4-NOT complex
- nucleus
- cytosol
| Biological process | - nuclear-transcribed mRNA poly(A) tail shortening
- regulation of transcription, DNA-templated
- RNA phosphodiester bond hydrolysis, exonucleolytic
- mRNA processing
- transcription, DNA-templated
- positive regulation of cytoplasmic mRNA processing body assembly
- mRNA destabilization
- positive regulation of cell population proliferation
- gene silencing
- regulation of translation
- nucleic acid phosphodiester bond hydrolysis
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001286790 NM_144571 NM_001365006 NM_001365007 |
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NM_001285511 NM_001285514 NM_144910 NM_178854 |
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RefSeq (protein) | |
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NP_001273719 NP_653172 NP_001351935 NP_001351936 |
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NP_001272440 NP_001272443 NP_659159 NP_849185 |
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Location (UCSC) | Chr 4: 77.71 – 77.82 Mb | Chr 5: 96.22 – 96.31 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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