FARP1

Protein-coding gene in the species Homo sapiens
FARP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4H6Y

Identifiers
AliasesFARP1, CDEP, FARP1-IT1, PLEKHC2, PPP1R75, FERM, ARH/RhoGEF and pleckstrin domain protein 1
External IDsOMIM: 602654; MGI: 2446173; HomoloGene: 38098; GeneCards: FARP1; OMA:FARP1 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for FARP1
Genomic location for FARP1
Band13q32.2Start98,142,562 bp[1]
End98,455,176 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for FARP1
Genomic location for FARP1
Band14|14 E5Start121,272,612 bp[2]
End121,521,156 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • renal medulla

  • stromal cell of endometrium

  • corpus epididymis

  • ganglionic eminence

  • human kidney

  • ventricular zone

  • epithelium of colon

  • right lobe of liver

  • parotid gland

  • thyroid gland
Top expressed in
  • internal carotid artery

  • external carotid artery

  • mandibular prominence

  • molar

  • maxillary prominence

  • hand

  • Gonadal ridge

  • medullary collecting duct

  • vas deferens

  • pituitary gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • guanyl-nucleotide exchange factor activity
  • cytoskeletal protein binding
Cellular component
  • cytosol
  • cell projection
  • membrane
  • filopodium
  • extrinsic component of cytoplasmic side of plasma membrane
  • plasma membrane
  • dendritic spine
  • synapse
  • cell junction
  • dendrite
  • neuron projection
  • cytoskeleton
  • cytoplasm
Biological process
  • dendrite morphogenesis
  • negative regulation of phosphatase activity
  • multicellular organism development
  • synapse assembly
  • regulation of Rho protein signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10160

223254

Ensembl

ENSG00000152767

ENSMUSG00000025555

UniProt

Q9Y4F1

F8VPU2

RefSeq (mRNA)

NM_001001715
NM_001286839
NM_005766

NM_134082

RefSeq (protein)

NP_001001715
NP_001273768
NP_005757

NP_598843

Location (UCSC)Chr 13: 98.14 – 98.46 MbChr 14: 121.27 – 121.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.[5][6]

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152767 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025555 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y (Jan 1998). "Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors". Biochem Biophys Res Commun. 241 (2): 369–75. doi:10.1006/bbrc.1997.7826. PMID 9425278.
  6. ^ a b "Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)".

Further reading

  • Zhuang B, Su YS, Sockanathan S (February 2009). "FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling". Neuron. 61 (3): 359–72. doi:10.1016/j.neuron.2008.12.022. PMC 2654783. PMID 19217374.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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