FARP2

Protein-coding gene in the species Homo sapiens

FARP2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4GYV, 4GZU

Identifiers
AliasesFARP2, FIR, FRG, PLEKHC3, FERM, ARH/RhoGEF and pleckstrin domain protein 2
External IDsOMIM: 617586; MGI: 2385126; HomoloGene: 8877; GeneCards: FARP2; OMA:FARP2 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for FARP2
Genomic location for FARP2
Band2q37.3Start241,356,285 bp[1]
End241,494,841 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for FARP2
Genomic location for FARP2
Band1|1 DStart93,439,801 bp[2]
End93,549,698 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of colon

  • sural nerve

  • right testis

  • left testis

  • right hemisphere of cerebellum

  • skin of leg

  • skin of abdomen

  • rectum

  • mucosa of sigmoid colon

  • mucosa of transverse colon
Top expressed in
  • fossa

  • calvaria

  • primary oocyte

  • zygote

  • retinal pigment epithelium

  • left lobe of liver

  • secondary oocyte

  • epithelium of lens

  • body of femur

  • molar
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • cytoskeletal protein binding
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytosol
  • cytoskeleton
  • cytoplasm
Biological process
  • osteoclast differentiation
  • neuron remodeling
  • actin cytoskeleton reorganization
  • regulation of integrin activation
  • podosome assembly
  • cell adhesion
  • Rac protein signal transduction
  • regulation of Rho protein signal transduction
  • semaphorin-plexin signaling pathway
  • hair cycle process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9855

227377

Ensembl

ENSG00000006607

ENSMUSG00000034066

UniProt

O94887

Q91VS8

RefSeq (mRNA)

NM_001282983
NM_001282984
NM_014808

NM_145519

RefSeq (protein)

NP_001269912
NP_001269913
NP_055623

NP_663494

Location (UCSC)Chr 2: 241.36 – 241.49 MbChr 1: 93.44 – 93.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene.[5][6][7]

Interactions

FARP2 has been shown to interact with PDZK1.[8]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000006607 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034066 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. ^ Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M (Oct 2002). "A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling". The Journal of Neuroscience. 22 (19): 8504–13. doi:10.1523/JNEUROSCI.22-19-08504.2002. PMC 6757789. PMID 12351724.
  7. ^ "Entrez Gene: FARP2 FERM, RhoGEF and pleckstrin domain protein 2".
  8. ^ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

Further reading

  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
  • Miyamoto Y, Yamauchi J, Itoh H (Aug 2003). "Src kinase regulates the activation of a novel FGD-1-related Cdc42 guanine nucleotide exchange factor in the signaling pathway from the endothelin A receptor to JNK". The Journal of Biological Chemistry. 278 (32): 29890–900. doi:10.1074/jbc.M301559200. PMID 12771149.
  • Sanger Centre T, Washington University Genome Sequencing Cente T (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Overview of all the structural information available in the PDB for UniProt: Q91VS8 (FERM, ARHGEF and pleckstrin domain-containing protein 2) at the PDBe-KB.
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