RAB25

Protein-coding gene in the species Homo sapiens
RAB25
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2OIL, 3TSO

Identifiers
AliasesRAB25, CATX-8, RAB11C, member RAS oncogene family
External IDsOMIM: 612942; MGI: 1858203; HomoloGene: 22995; GeneCards: RAB25; OMA:RAB25 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RAB25
Genomic location for RAB25
Band1q22Start156,061,160 bp[1]
End156,070,504 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for RAB25
Genomic location for RAB25
Band3|3 F1Start88,449,336 bp[2]
End88,455,607 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • skin of abdomen

  • skin of leg

  • gums

  • mucosa of pharynx

  • gingival epithelium

  • skin of thigh

  • oral cavity

  • rectum

  • human penis
Top expressed in
  • transitional epithelium of urinary bladder

  • lip

  • esophagus

  • epithelium of stomach

  • left colon

  • skin of external ear

  • mucous cell of stomach

  • cervix

  • pyloric antrum

  • duodenum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • myosin V binding
  • protein binding
  • GTPase activity
Cellular component
  • pseudopodium membrane
  • plasma membrane
  • cell projection
  • pseudopodium
  • extracellular exosome
  • cytoplasmic vesicle
  • membrane
  • endosome
  • recycling endosome
Biological process
  • protein transport
  • regulation of vesicle-mediated transport
  • positive regulation of epithelial cell migration
  • epithelial cell morphogenesis
  • positive regulation of cell population proliferation
  • pseudopodium organization
  • transport
  • intracellular protein transport
  • exocytosis
  • Rab protein signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57111

53868

Ensembl

ENSG00000132698

ENSMUSG00000008601

UniProt

P57735

Q9WTL2

RefSeq (mRNA)

NM_020387

NM_016899

RefSeq (protein)

NP_065120

NP_058595

Location (UCSC)Chr 1: 156.06 – 156.07 MbChr 3: 88.45 – 88.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene.[5][6] It is thought to act as a promoter of tumor development.[7]

Interactions

RAB25 has been shown to interact with RAB11FIP2[8][9] and RAB11FIP5.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132698 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008601 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pereira-Leal JB, Seabra MC (November 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.
  6. ^ "Entrez Gene: RAB25 RAB25, member RAS oncogene family".
  7. ^ Kessler, D; Gruen, GC; Heider, D; Morgner, J; Reis, H; Schmid, KW; Jendrossek, V (2012). "The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration". Cellular Physiology and Biochemistry. 29 (5–6): 647–56. doi:10.1159/000295249. PMID 22613965.
  8. ^ a b Hales, C M; Griner R; Hobdy-Henderson K C; Dorn M C; Hardy D; Kumar R; Navarre J; Chan E K; Lapierre L A; Goldenring J R (October 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.
  9. ^ a b Prekeris, R; Davies J M; Scheller R H (October 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. ISSN 0021-9258. PMID 11481332.

Further reading

  • Goldenring JR, Shen KR, Vaughan HD, Modlin IM (1993). "Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung". J. Biol. Chem. 268 (25): 18419–22. doi:10.1016/S0021-9258(17)46639-7. PMID 8360141.
  • Ray GS, Lee JR, Nwokeji K, et al. (1997). "Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia". Lab. Invest. 77 (5): 503–11. PMID 9389793.
  • Lapierre LA, Kumar R, Hales CM, et al. (2001). "Myosin vb is associated with plasma membrane recycling systems". Mol. Biol. Cell. 12 (6): 1843–57. doi:10.1091/mbc.12.6.1843. PMC 37346. PMID 11408590.
  • Prekeris R, Davies JM, Scheller RH (2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.
  • Hales CM, Griner R, Hobdy-Henderson KC, et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
  • Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Fan Y, Xin XY, Chen BL, Ma X (2007). "Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo". Pathology. 38 (6): 561–7. doi:10.1080/00313020601024037. PMID 17393986. S2CID 85960469.
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  • 2oil: Crystal structure of human RAB25 in complex with GDP
    2oil: Crystal structure of human RAB25 in complex with GDP


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