SFRS3

Protein-coding gene in the species Homo sapiens

SRSF3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2I38

Identifiers

Aliases

SRSF3, SFRS3, SRp20, serine/arginine-rich splicing factor 3, serine and arginine rich splicing factor 3

External IDs

OMIM: 603364; MGI: 98285; HomoloGene: 55708; GeneCards: SRSF3; OMA:SRSF3 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.31-p21.2	Start	36,594,353 bp^[1]
Band	6p21.31-p21.2	End	36,605,600 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17 A3.3\|17 15.03 cM	Start	29,251,602 bp^[2]
Band	17 A3.3\|17 15.03 cM	End	29,262,347 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

ganglionic eminence

monocyte

pericardium

thymus

mucosa of sigmoid colon

vena cava

lymph node

epithelium of nasopharynx

amniotic fluid

Top expressed in

genital tubercle

ventricular zone

tail of embryo

medial ganglionic eminence

primitive streak

abdominal wall

embryo

embryo

neural tube

mandibular prominence

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleic acid binding sequence-specific mRNA binding protein binding RNA binding
Cellular component	nucleus cytoplasm nucleoplasm nuclear speck
Biological process	termination of RNA polymerase II transcription mRNA 3'-end processing mRNA splicing, via spliceosome mRNA export from nucleus mRNA transport mRNA processing RNA splicing regulation of mRNA splicing, via spliceosome RNA export from nucleus transport regulation of alternative mRNA splicing, via spliceosome mRNA cis splicing, via spliceosome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6428


20383

Ensembl


ENSG00000112081


ENSMUSG00000071172

UniProt


P84103


P84104

RefSeq (mRNA)


NM_003017


NM_013663

RefSeq (protein)


NP_003008


NP_038691

Location (UCSC)

Chr 6: 36.59 – 36.61 Mb

Chr 17: 29.25 – 29.26 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.^[5]^[6]

Browser View

UCSC Genome Browser View

UCSC Gene details page

Interactions

SFRS3 has been shown to interact with RBM7.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112081 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071172 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zahler AM; Lane WS; Stolk JA; Roth MB (Jun 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
^ "Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3".
^ Guo, Taylor B; Boros Laszlo G; Chan Kam C; Hikim Amiya P Sinha; Hudson Alan P; Swerdloff Ronald S; Mitchell Aaron P; Salameh Wael A (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. ISSN 0196-3635. PMID 12634307.

Ayane M; Preuss U; Köhler G; Nielsen PJ (1991). "A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs". Nucleic Acids Res. 19 (6): 1273–8. doi:10.1093/nar/19.6.1273. PMC 333853. PMID 2030943.
Gui JF; Lane WS; Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298. S2CID 4275539. Archived from the original on 2020-12-03. Retrieved 2019-12-14.
Cáceres JF; Screaton GR; Krainer AR (1998). "A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm". Genes Dev. 12 (1): 55–66. doi:10.1101/gad.12.1.55. PMC 316398. PMID 9420331.
Zhang WJ; Wu JY (1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol. Cell. Biol. 18 (2): 676–84. doi:10.1128/MCB.18.2.676. PMC 108778. PMID 9447963.
Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
Papoutsopoulou S, Nikolakaki E, Chalepakis G, et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.
Barnard DC; Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.
Shnyreva M, Schullery DS, Suzuki H, et al. (2000). "Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein". J. Biol. Chem. 275 (20): 15498–503. doi:10.1074/jbc.275.20.15498. PMID 10809782.
Elliott DJ, Bourgeois CF, Klink A, et al. (2000). "A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5717–22. Bibcode:2000PNAS...97.5717E. doi:10.1073/pnas.97.11.5717. PMC 18499. PMID 10823932.
Huang Y; Steitz JA (2001). "Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA". Mol. Cell. 7 (4): 899–905. doi:10.1016/S1097-2765(01)00233-7. PMID 11336712.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Barnard DC; Li J; Peng R; Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins". RNA. 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273. PMID 11991645.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Guo TB, Boros LG, Chan KC, et al. (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID 12634307.
Tai HH, Geisterfer M, Bell JC, et al. (2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. PMID 12890497.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dettwiler S, Aringhieri C, Cardinale S, et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization" (PDF). J. Biol. Chem. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763. S2CID 39752996.
Lehner B; Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.