SLX4 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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4M7C, 4UYI, 4ZOU |
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Identifiers |
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Aliases | SLX4, BTBD12, FANCP, MUS312, SLX4 structure-specific endonuclease subunit |
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External IDs | OMIM: 613278; MGI: 106299; HomoloGene: 23770; GeneCards: SLX4; OMA:SLX4 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 16 (human)[1] |
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| Band | 16p13.3 | Start | 3,581,181 bp[1] |
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End | 3,611,606 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 16 (mouse)[2] |
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| Band | 16 A1|16 2.34 cM | Start | 3,979,105 bp[2] |
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End | 4,003,770 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right hemisphere of cerebellum
- pancreatic ductal cell
- gonad
- granulocyte
- testicle
- right testis
- left testis
- stromal cell of endometrium
- ventricular zone
- tibialis anterior muscle
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| Top expressed in | - zygote
- spermatocyte
- genital tubercle
- tail of embryo
- spermatid
- gastrula
- neural layer of retina
- secondary oocyte
- seminiferous tubule
- ventricular zone
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - protein binding
- enzyme activator activity
- endodeoxyribonuclease activity
- crossover junction endodeoxyribonuclease activity
- 5'-flap endonuclease activity
- 3'-flap endonuclease activity
| Cellular component | - ERCC4-ERCC1 complex
- nucleoplasm
- cell junction
- Holliday junction resolvase complex
- nucleus
- telomere
- cytosol
- Slx1-Slx4 complex
| Biological process | - nucleotide-excision repair
- DNA recombination
- positive regulation of t-circle formation
- cellular response to DNA damage stimulus
- DNA double-strand break processing involved in repair via single-strand annealing
- DNA replication
- response to intra-S DNA damage checkpoint signaling
- positive regulation of catalytic activity
- DNA repair
- interstrand cross-link repair
- resolution of meiotic recombination intermediates
- double-strand break repair via homologous recombination
- meiotic DNA double-strand break processing
- telomeric D-loop disassembly
- t-circle formation
- negative regulation of telomere maintenance via telomere lengthening
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | NP_803423 NP_001389852 NP_001389853 NP_001389854 NP_001389855
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NP_001389856 NP_001389857 NP_001389859 NP_001389860 |
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Location (UCSC) | Chr 16: 3.58 – 3.61 Mb | Chr 16: 3.98 – 4 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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