CXCL11
| Chemokine (C-X-C motif) ligand 11 | |||||||||||||
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 PDB rendering based on 1rjt. | |||||||||||||
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| 标识 | |||||||||||||
| 代号 | CXCL11; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B; b-R1 | ||||||||||||
| 扩展标识 | 遗传学：604852 鼠基因：1860203 同源基因：3944 GeneCards: CXCL11 Gene | ||||||||||||
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| 物种 | 人类 | 小鼠 | |||||||||||
| Entrez | 6373 | 56066 | |||||||||||
| Ensembl | ENSG00000169248 | n/a | |||||||||||
| UniProt | O14625 | Q9JHH5 | |||||||||||
| mRNA序列 | NM_005409 | NM_019494.1 | |||||||||||
| 蛋白序列 | NP_005400 | NP_062367.1 | |||||||||||
| 基因位置 | Chr 4: 76.95 – 76.96 Mb | n/a | |||||||||||
| PubMed查询 | [1] | [2] | |||||||||||
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CXCL11（英語：Chemokine (C-X-C motif) ligand 11）是一小分子的细胞因子属于CXC趋化因子家族[1]，又被称作“干扰素诱导的T细胞a趋化因子”（Interferon-inducible T-cell alpha chemoattractant (I-TAC)[1]。
表达
在白细胞，胰腺和肝脏中表达水平高，在胸腺，脾和肺有中等水平的表达，在小肠，胎盘和前列腺中表达水平低[1]。干扰素伽玛和干扰素－b可以在单核细胞[1]，支气管上皮细胞[2]，中性粒细胞[3]，角质形成细胞[4]，和内皮细胞诱导CXCL11的表达。
受体
CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用[1][5][6]。CXCL11也可以结合到趋化因子受体CCR3上而阻止CCR3配体的结合[7]。
功能
CXCL11对活化的T细胞，中性粒细胞和单核细胞有细胞趋化作用[1]。
参见
参考文献
- ^ 1.0 1.1 1.2 1.3 1.4 1.5 Cole et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 187: 2009-2021, 1998.
- ^ Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., Garcia-Zepeda, E. A., Hamid, Q., Luster, A. D. (1999) The T cell-specific CXC chemokines IP-10, MIG, and I-TAC are expressed by activated human bronchial epithelial cells J. Immunol. 162,3549-3558
- ^ Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L., Olsen, H., Murphy, M., Liao, F., Farber, J., Cassatella, M. A. (1999) Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils J. Immunol. 162,4928-4937.
- ^ Tensen, C. P., Flier, J., Van Der Raaij-Helmer, E. M., Sampat-Sardjoepersad, S., Van Der Schors, R. C., Leurs, R., Scheper, R. J., Boorsma, D. M., Willemze, R. (1999) Human IP-9: a keratinocyte-derived high-affinity CXC-chemokine ligand for the IP-10/MIG receptor (CXCR3) J. Invest. Dermatol. 112,716-72.
- ^ Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
- ^ Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
- ^ Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001 Feb 2;276(5):2986-91
外部链接
- Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.（页面存档备份，存于互联网档案馆）
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